Modulation of salivary secretion by novel transport regulation factor
| Project/Area Number |
22791789
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KITAYAMA Tomoya 広島大学, 大学院・医歯薬学総合研究科, 助教 (60363082)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | PRIP / 分泌 / インスリン / GABARAP / 開口分泌 |
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| Research Abstract |
PRIP(a novel transport regulation factor) was knocked down by siRNA in MIN6 cells(murineβcell line). We found that the down-regulation of PRIP induces a reduction of insulin secretion, the process of which is modulated by GABARAP, a PRIP binding protein.
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Report
(3 results)
Research Products
(3 results)
