Elucidation of mechanism of BMP signaling in bone invasion by oral squamous cell carcinoma cells
| Project/Area Number |
22791795
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Saitama Medical University |
|---|
Principal Investigator |
SHIN Masashi 埼玉医科大学, 医学部, 研究員 (70549261)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 口腔癌 / シグナル伝達 / 骨 |
|---|
| Research Abstract |
Cancer cells in the oral cavity frequently invade alveolar bone. Although bone invasion by oral carcinoma cells is a critical factor for determination of prognosis, molecular mechanisms are unclear because an animal model in vivo of this event has not been established yet. In the present study, we examined roles of BMP signaling in bone invasion by cancer cells in vivo and in vitro. Over-expression of a constitutively active BMP receptor in vitro induced morphological changes. A cell line stably expressing a constitutively active BMP receptor, but not an empty vector, showed bone invasion in vivo. These findings suggest that BMP signaling stimulates bone invasion by cancer cells.
|
Report
(3 results)
Research Products
(37 results)
-
[Journal Article] Selective inhibition of NF-κB suppresses bone invasion by oral squamouscell carcinoma in vivo2012
Author(s)
Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, AokiK, Ohya K, Okamoto M, Tominaga K, TakahashiT, Nakanishi O, Jimi E
-
Journal Title
Int J Cancer
Volume: (in press)
Related Report
Peer Reviewed
-
[Journal Article] Identification and functional analysis of Zranb 2 as a novel Smad-bindingprotein that suppresses BMP signaling2012
Author(s)
Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, NatsumeT, Katagiri T
-
Journal Title
J Cell Biochem
Volume: 113
Pages: 808-814
Related Report
Peer Reviewed
-
[Journal Article] Selective inhibition of NF-kB suppresses bone invasion by oral squamous cell carcinoma in vivo2012
Author(s)
Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakanishi O, Jimi E
-
Journal Title
International Journal of Cancer
Volume: (in press)
Issue: 5
DOI
Related Report
Peer Reviewed
-
-
-
[Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H2011
Author(s)
Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T
-
Journal Title
Biochem Biophys Res Commun
Volume: 407
Pages: 213-218
Related Report
Peer Reviewed
-
[Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminaldomain phosphatase 1, a Smad phosphatase2011
Author(s)
Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, NojimaJ, Ono Y, Yoda T, Fukuda T, Katagiri T
-
Journal Title
Mol Endocrinol
Volume: 25
Pages: 474-481
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
