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Elucidation of mechanism of BMP signaling in bone invasion by oral squamous cell carcinoma cells

Research Project

Project/Area Number 22791795
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionSaitama Medical University

Principal Investigator

SHIN Masashi  埼玉医科大学, 医学部, 研究員 (70549261)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口腔癌 / シグナル伝達 / 骨
Research Abstract

Cancer cells in the oral cavity frequently invade alveolar bone. Although bone invasion by oral carcinoma cells is a critical factor for determination of prognosis, molecular mechanisms are unclear because an animal model in vivo of this event has not been established yet. In the present study, we examined roles of BMP signaling in bone invasion by cancer cells in vivo and in vitro. Over-expression of a constitutively active BMP receptor in vitro induced morphological changes. A cell line stably expressing a constitutively active BMP receptor, but not an empty vector, showed bone invasion in vivo. These findings suggest that BMP signaling stimulates bone invasion by cancer cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (24 results) Remarks (3 results)

  • [Journal Article] Selective inhibition of NF-κB suppresses bone invasion by oral squamouscell carcinoma in vivo2012

    • Author(s)
      Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, AokiK, Ohya K, Okamoto M, Tominaga K, TakahashiT, Nakanishi O, Jimi E
    • Journal Title

      Int J Cancer

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of Zranb 2 as a novel Smad-bindingprotein that suppresses BMP signaling2012

    • Author(s)
      Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, NatsumeT, Katagiri T
    • Journal Title

      J Cell Biochem

      Volume: 113 Pages: 808-814

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective inhibition of NF-kB suppresses bone invasion by oral squamous cell carcinoma in vivo2012

    • Author(s)
      Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakanishi O, Jimi E
    • Journal Title

      International Journal of Cancer

      Volume: (in press) Issue: 5

    • DOI

      10.1002/ijc.27435

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2012

    • Author(s)
      Ohte S
    • Journal Title

      J Cell Biochem

      Volume: 113 Issue: 3 Pages: 808-814

    • DOI

      10.1002/jcb.23408

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The inhibition of RANKL/RANK signalingby osteoprotegerin suppresses boneinvasion by oral squamous cell carcinoma cells2011

    • Author(s)
      Shin M, Matsuo K, Tada T, FukushimaH, Furuta H, Ozeki S, Kadowaki T, YamamotoK, Okamoto M, Jimi E.
    • Journal Title

      Carcinogenesis

      Volume: 32 Pages: 1634-1640

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H2011

    • Author(s)
      Ohte S, Shin M, Sasanuma H, Yoneyama K, Akita M, Ikebuchi K, Jimi E, Maruki Y, Matsuoka M, Namba A, Tomoda H, Okazaki Y, Ohtake A, Oda H, Owan I, Yoda T, Furuya H, Kamizono J, Kitoh H, Nakashima Y, Susami T, Haga N, Komori T, Katagiri T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407 Pages: 213-218

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminaldomain phosphatase 1, a Smad phosphatase2011

    • Author(s)
      Kokabu S, Ohte S, Sasanuma H, Shin M, Yoneyama K, Murata E, Kanomata K, NojimaJ, Ono Y, Yoda T, Fukuda T, Katagiri T
    • Journal Title

      Mol Endocrinol

      Volume: 25 Pages: 474-481

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The inhibition of RANKL/RANK signaling by osteoprotegerin suppresses bone in vasion by oral squamous cell carcinoma cells2011

    • Author(s)
      Shin M, et al
    • Journal Title

      Carcinogenesis

      Volume: 32 Issue: 11 Pages: 1634-1640

    • DOI

      10.1093/carcin/bgr198

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mutation of ALK2, L196P, found in the most benign case of fibrodysplasia ossificans progressiva activates BMP-specific intracellular signaling equivalent to a typical mutation, R206H.2011

    • Author(s)
      Ohte S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 407(1) Pages: 213-218

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of BMP-Smad signaling axis-induced osteoblastic differentiation by small C-terminal domain phosphatase 1, a Smad phosphatase.2011

    • Author(s)
      Kokabu S
    • Journal Title

      Mol Endcrinol

      Volume: 25(3) Pages: 474-481

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] BMP初期応答遺伝子のIdファミリーにおけるBMP応答配列の同定2011

    • Author(s)
      進正史、古株彰一郎、自見英治郎、片桐岳信
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Final Research Report
  • [Presentation] BMP初期応答遺伝子のIdファミリーにおけるBMP応答配列の同定2011

    • Author(s)
      進正史
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜県岐阜市
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] BMP Signaling Inhibits Myogenesis and Induces Osteoblastic Differentiation in Satellite Cells During Muscle Regeneration2011

    • Author(s)
      Katagiri T
    • Organizer
      2011 ASBMR Annual Meeting
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] BMP Type II Receptors Further Stimulate Constitutively Activated Mutant ALK2 found in Fibrodysplasia Ossiiicans Progressiva2011

    • Author(s)
      Ohte S
    • Organizer
      2011 ASBMR Annual Meeting
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Identification of a Common BMP-responsive Element in the Id1, Id2 and Id3 Genes2011

    • Author(s)
      Masashi Shin, Satoshi Ohte, Katsumi Yoneyama, Hiroki Sasanuma, Shoichiro Kokabu, Toru Fukuda, Eijiro Jimi, Takenobu Katagiri
    • Organizer
      2011 ASBMR Annual Meeting
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] BMP初期応答遺伝子におけるBMP応答配列の解析2011

    • Author(s)
      進正史
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 進行性骨化性線維異形成症(FOP)で同定されたALK2変異体はII型BMP受容体によってさらに活性化される2011

    • Author(s)
      大手聡
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨格筋の再生と異所性骨化におけるサテライト細胞に対するBMPシグナルの役割2011

    • Author(s)
      笹沼寛樹
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] BMP signaling stimulates alveolar bone invasion by melanoma cells2010

    • Author(s)
      Masashi Shin, Hidefumi Fukushima, Hiroyuki Furuta, Kazuhiro Aoki, Masud Khan, Keiichi Ohya, Takenobu Katagiri, and Eijiro Jimi
    • Organizer
      16th International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
    • Place of Presentation
      奈良
    • Year and Date
      2010-11-15
    • Related Report
      2011 Final Research Report
  • [Presentation] BMP signaling stimulates alveolar bone invasion by melanoma cells2010

    • Author(s)
      Shin M
    • Organizer
      16^<th> International Conference of the INTERNATIONAL SOCIETY OF DIFFERENTIATION
    • Place of Presentation
      奈良
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] SCP1はBMP誘導性の骨芽細胞分化においてSmadの下流因子を抑制する2010

    • Author(s)
      進正史
    • Organizer
      第8回RCGMフロンティア国際シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨芽細胞分化におけるBMPとWntシグナルの相互作用の解明2010

    • Author(s)
      笹沼寛樹
    • Organizer
      第8回RCGMフロンティア国際シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規Smad結合因子Zranb2はBMPシグナル抑制因子である2010

    • Author(s)
      大手聡
    • Organizer
      第8回RCGMフロンティア国際シンポジウム
    • Place of Presentation
      埼玉
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of Zranb2, a novel R-Smads binding protein, as a suppressor of BMP signaling.2010

    • Author(s)
      Ohte S
    • Organizer
      2010 ASBMR Annual Meeting
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Platelet Factor 4 is a novel potentiator of BMP-induced osteoblastic differentiation and bone formation.2010

    • Author(s)
      Katagiri T
    • Organizer
      2010 ASBMR Annual Meeting
    • Place of Presentation
      トロント(カナダ)
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔癌細胞の顎骨浸潤におけるBMPシグナル活性化の役割2010

    • Author(s)
      進正史、福島秀文、古田弘之、青木和広、マスードカーン、大谷啓一、片桐岳信、自見英治郎
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌の顎骨浸潤モデルにおけるNF-kBシグナルによる顎骨浸潤制御機構の解明2010

    • Author(s)
      古田弘之、進正史、福島秀文、自見英治郎
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔癌細胞の顎骨浸潤におけるBMPシグナル活性化の役割2010

    • Author(s)
      進正史
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔扁平上皮癌の顎骨浸潤モデルにおけるNF-kBシグナルによる顎骨浸潤制御機構の解明2010

    • Author(s)
      古田弘之
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] SmadホスファターゼによるBMP誘導性骨芽細胞分化の抑制機序2010

    • Author(s)
      片桐岳信
    • Organizer
      第52回歯科基礎医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] PPM1A and SCP1, Smad phosphatases, inhibits BMP-induced osteoblastic differentiation by different molecular mechanisms2010

    • Author(s)
      Katagiri T
    • Organizer
      8^<th> International BMP Conference
    • Place of Presentation
      ルーベン(ベルギー)
    • Year and Date
      2010-09-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification and characterization of a nuclear protein as a co-suppress or of BMP-regulated R-Smads2010

    • Author(s)
      Ohte S
    • Organizer
      8^<th> International BMP Conference
    • Place of Presentation
      ルーベン(ベルギー)
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 血小板第4因子は血中の新規BMP活性促進因子である2010

    • Author(s)
      片桐岳信
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規R-Smad結合因子ZRANB2のBMPシグナル阻害活性2010

    • Author(s)
      大手聡
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.saitama-raed.ac.jp/genome/Div04_PPhysiol/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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