Research Project
Grant-in-Aid for Young Scientists (B)
Cancer cells in the oral cavity frequently invade alveolar bone. Although bone invasion by oral carcinoma cells is a critical factor for determination of prognosis, molecular mechanisms are unclear because an animal model in vivo of this event has not been established yet. In the present study, we examined roles of BMP signaling in bone invasion by cancer cells in vivo and in vitro. Over-expression of a constitutively active BMP receptor in vitro induced morphological changes. A cell line stably expressing a constitutively active BMP receptor, but not an empty vector, showed bone invasion in vivo. These findings suggest that BMP signaling stimulates bone invasion by cancer cells.
All 2012 2011 2010 Other
All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (24 results) Remarks (3 results)
Int J Cancer
Volume: (in press)
J Cell Biochem
Volume: 113 Pages: 808-814
International Journal of Cancer
Volume: (in press) Issue: 5
10.1002/ijc.27435
Volume: 113 Issue: 3 Pages: 808-814
10.1002/jcb.23408
Carcinogenesis
Volume: 32 Pages: 1634-1640
Biochem Biophys Res Commun
Volume: 407 Pages: 213-218
Mol Endocrinol
Volume: 25 Pages: 474-481
Volume: 32 Issue: 11 Pages: 1634-1640
10.1093/carcin/bgr198
Volume: 407(1) Pages: 213-218
Mol Endcrinol
Volume: 25(3) Pages: 474-481
http://www.saitama-med.ac.jp/genome/Div04_PPhysiol/index.html
http://www.saitama-raed.ac.jp/genome/Div04_PPhysiol/index.html