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Examination of the ASK1 involvement in a reactive oxygen spiecies-inducitive osteoclast activation signal.

Research Project

Project/Area Number 22791805
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionAichi Gakuin University

Principal Investigator

KONDO Hisataka  愛知学院大学, 歯学部, 助教 (40469002)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsシグナル伝達 / ストレス / 破骨細胞 / 骨芽細胞
Research Abstract

It has been reported that reactive oxygen species is important for osteoclastogenesis and activation of apoptosis signal regulating kinase 1(ASK1). However, the role of ASK1 on osteoclastogenesis is still unknown. We investigated wheather ASK1 is involved in osteoclastogenesis and found that ASK1 involved in reactive oxygen spiecies-inducitive osteoclast activation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results)

  • [Journal Article] The neuro-osteogenic network : The sympathetic regulation of bone resorption2012

    • Author(s)
      Togari A, Arai M, Kondo H, Kodama D, Niwa Y.
    • Journal Title

      Japanese Dental Science

      Volume: (印刷中)

    • NAID

      10030957426

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of β-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast2012

    • Author(s)
      Komoto S, Kondo H, Fukuta O, Togari A.
    • Journal Title

      Chronobiol Int

      Volume: 29(1) Pages: 66-74

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of ss-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast2012

    • Author(s)
      Komoto S, Kondo H, Fukuta O, Togari A
    • Journal Title

      Chronobiology International

      Volume: 29(1) Pages: 66-74

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The neuro-osteogenic network : The sympathetic regulation of bone resorption2012

    • Author(s)
      Togari A, Arai M, Kondo H, Kodama D, Niwa Y
    • Journal Title

      Japanese Dental Science

      Volume: (印刷中)

    • NAID

      10030957426

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss2011

    • Author(s)
      Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M.
    • Journal Title

      J Cell Biochem

      Volume: 112(12) Pages: 3525-30

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss2011

    • Author(s)
      Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: 112(12) Pages: 3525-3530

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Continuous treatment with a low-dose β-agonist reduces bone mass by increasing bone resorption wighout suppressing bone formation2010

    • Author(s)
      Kondo H, Togari A.
    • Journal Title

      Calcified Tissue International

      Volume: 88(1) Pages: 23-32

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Continuous treatment with a low-dose β-agonist reduces bone mass by increasing bone resorption wighout suppressing bone formation.2010

    • Author(s)
      Hisataka Kondo, Akifumi Togari
    • Journal Title

      Calcified Tissue International

      Volume: 88巻 Pages: 23-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗酸化剤αリポ酸は骨吸収を抑制し骨形成を促進することでβ作動薬誘導性骨粗鬆症を予防する2011

    • Author(s)
      近藤久貴、戸苅彰史
    • Organizer
      第74回学術大会愛知学院大学歯学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-12-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト骨芽細胞SaM-1における時計遺伝子の役割2011

    • Author(s)
      河本新太郎、近藤久貴、戸苅彰史、福田理
    • Organizer
      第49回日本小児歯科学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2011-11-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 実験的歯の移動に交感神経が関与する2011

    • Author(s)
      近藤真代、近藤久貴、宮澤健、後藤滋巳、戸苅彰史
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 抗酸化剤αリポ酸によるβ作動薬誘導性骨粗鬆症の予防効果2011

    • Author(s)
      近藤久貴、戸苅彰史
    • Organizer
      第29回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低濃度βアゴニストの持続投与は骨形成に影響を与えず、骨吸収を促進し骨量を減少させる2010

    • Author(s)
      近藤久貴
    • Organizer
      第28回骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 低濃度βアゴニストの持続投与は骨形成に影響を与えず、骨吸収を促進し骨量を減少させる2010

    • Author(s)
      近藤久貴
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 交感神経活動はROSを介し破骨細胞分化を促進する2010

    • Author(s)
      近藤久貴
    • Organizer
      第218回松本歯科大学大学院セミナー
    • Place of Presentation
      塩尻
    • Year and Date
      2010-07-08
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 交感神経活動はReactive oxygen species(ROS)を介し破骨細胞分化を促進する2010

    • Author(s)
      近藤久貴
    • Organizer
      第45回骨Ca代謝研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-04
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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