Examination of the ASK1 involvement in a reactive oxygen spiecies-inducitive osteoclast activation signal.

• Project/Area Number: 22791805
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Functional basic dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: KONDO Hisataka 愛知学院大学, 歯学部, 助教 (40469002)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: シグナル伝達 / ストレス / 破骨細胞 / 骨芽細胞

Research Abstract

It has been reported that reactive oxygen species is important for osteoclastogenesis and activation of apoptosis signal regulating kinase 1(ASK1). However, the role of ASK1 on osteoclastogenesis is still unknown. We investigated wheather ASK1 is involved in osteoclastogenesis and found that ASK1 involved in reactive oxygen spiecies-inducitive osteoclast activation.

Research Products

• [Journal Article] The neuro-osteogenic network : The sympathetic regulation of bone resorption (2012)
  • Author(s): Togari A, Arai M, Kondo H, Kodama D, Niwa Y.
  • Journal Title: Japanese Dental Science Volume: (印刷中)
  • NAID: 10030957426
  • Peer Reviewed
• [Journal Article] Comparison of β-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast (2012)
  • Author(s): Komoto S, Kondo H, Fukuta O, Togari A.
  • Journal Title: Chronobiol Int Volume: 29(1) Pages: 66-74
  • Peer Reviewed
• [Journal Article] Comparison of ss-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast (2012)
  • Author(s): Komoto S, Kondo H, Fukuta O, Togari A
  • Journal Title: Chronobiology International Volume: 29(1) Pages: 66-74
  • Peer Reviewed
• [Journal Article] The neuro-osteogenic network : The sympathetic regulation of bone resorption (2012)
  • Author(s): Togari A, Arai M, Kondo H, Kodama D, Niwa Y
  • Journal Title: Japanese Dental Science Volume: (印刷中)
  • NAID: 10030957426
  • Peer Reviewed
• [Journal Article] MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss (2011)
  • Author(s): Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M.
  • Journal Title: J Cell Biochem Volume: 112(12) Pages: 3525-30
  • Peer Reviewed
• [Journal Article] MURF1 deficiency suppresses unloading-induced effects on osteoblasts and osteoclasts to lead to bone loss (2011)
  • Author(s): Kondo H, Ezura Y, Nakamoto T, Hayata T, Notomi T, Sorimachi H, Takeda S, Noda M
  • Journal Title: Journal of Cellular Biochemistry Volume: 112(12) Pages: 3525-3530
  • Peer Reviewed
• [Journal Article] Continuous treatment with a low-dose β-agonist reduces bone mass by increasing bone resorption wighout suppressing bone formation (2010)
  • Author(s): Kondo H, Togari A.
  • Journal Title: Calcified Tissue International Volume: 88(1) Pages: 23-32
  • Peer Reviewed
• [Journal Article] Continuous treatment with a low-dose β-agonist reduces bone mass by increasing bone resorption wighout suppressing bone formation. (2010)
  • Author(s): Hisataka Kondo, Akifumi Togari
  • Journal Title: Calcified Tissue International Volume: 88巻 Pages: 23-32
  • Peer Reviewed
• [Presentation] 抗酸化剤αリポ酸は骨吸収を抑制し骨形成を促進することでβ作動薬誘導性骨粗鬆症を予防する (2011)
  • Author(s): 近藤久貴、戸苅彰史
  • Organizer: 第74回学術大会愛知学院大学歯学会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-12-04
• [Presentation] ヒト骨芽細胞SaM-1における時計遺伝子の役割 (2011)
  • Author(s): 河本新太郎、近藤久貴、戸苅彰史、福田理
  • Organizer: 第49回日本小児歯科学会大会
  • Place of Presentation: 盛岡
  • Year and Date: 2011-11-28
• [Presentation] 実験的歯の移動に交感神経が関与する (2011)
  • Author(s): 近藤真代、近藤久貴、宮澤健、後藤滋巳、戸苅彰史
  • Organizer: 第53回歯科基礎医学会
  • Place of Presentation: 岐阜
  • Year and Date: 2011-10-01
• [Presentation] 抗酸化剤αリポ酸によるβ作動薬誘導性骨粗鬆症の予防効果 (2011)
  • Author(s): 近藤久貴、戸苅彰史
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2011-07-28
• [Presentation] 低濃度βアゴニストの持続投与は骨形成に影響を与えず、骨吸収を促進し骨量を減少させる (2010)
  • Author(s): 近藤久貴
  • Organizer: 第28回骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] 低濃度βアゴニストの持続投与は骨形成に影響を与えず、骨吸収を促進し骨量を減少させる (2010)
  • Author(s): 近藤久貴
  • Organizer: 第28回日本骨代謝学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-21
• [Presentation] 交感神経活動はROSを介し破骨細胞分化を促進する (2010)
  • Author(s): 近藤久貴
  • Organizer: 第218回松本歯科大学大学院セミナー
  • Place of Presentation: 塩尻
  • Year and Date: 2010-07-08
• [Presentation] 交感神経活動はReactive oxygen species(ROS)を介し破骨細胞分化を促進する (2010)
  • Author(s): 近藤久貴
  • Organizer: 第45回骨Ca代謝研究会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-06-04