Regulation of Serotonin receptor gene expression by brain-specific non-coding RNAs.

• Project/Area Number: 22791817
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: The Nippon Dental University
• Principal Investigator: SOENO Yuuichi 日本歯科大学, 生命歯学部, 講師 (70350139)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 病態病理学 / 歯学 / 病理学 / ノンコーディングRNA / snoRNA / 脳 / 摂食障害 / セロトニン受容体 / RNA-タンパク複合体

Research Abstract

While snoRNAs generally mediate the maturation of rRNAs, brain-specific MBII-52 snoRNA has a complementarity to serotonin receptor 2C mRNA. To investigate the not-yet-known function of MBII-52 we analyzed the transcripts and the MBII-52/protein complex in mouse brain. Our results demonstrated that MBII-52 form novel complexes with Nucleolin and ELAVL1, and that some MBII-52 variants are processed into a shorter form according to the nucleotide polymorphism.

Research Products

• [Journal Article] ノンコーディングRNAによる遺伝子発現制御と病態-セロトニン受容体修飾と摂食障害 (2011)
  • Author(s): 添野雄一, 藤田和也, 田谷雄二, 青葉孝昭
  • Journal Title: 歯学 Volume: 98 Pages: 185-188
  • NAID: 10029378994
• [Journal Article] Identification of novel ribonucleo-protein complexes from the brain-specific snoRNA MBII-52 (2010)
  • Author(s): Soeno, Y., Taya, Y., Stasyk, T., Huber, L. A., Aoba, T., Huttenhofer A.
  • Journal Title: RNA Volume: 16 Pages: 1293-1300
  • Peer Reviewed
• [Journal Article] Identification of novel ribonucleo-protein complexes from the brain-specific MBII-52 snoRNA (2010)
  • Author(s): Yuuichi SOENO
  • Journal Title: RNA Volume: 16 Pages: 1297-1300
  • Peer Reviewed
• [Presentation] Myoblast-differentiation and mRNA/miRNA expression in developmental mouse tongue (2012)
  • Author(s): Fujita K
  • Organizer: 41st Annual Meeting and Exhibition of the American Association for Dental Research
  • Place of Presentation: Tampa, Florida, USA
  • Year and Date: 2012-03-22
• [Presentation] マウス舌初期発生と筋芽細胞分化の分子制御:miRNA・タンパク質の発現局在 (2011)
  • Author(s): 藤田和也
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-12-13
• [Presentation] マウス顎顔面領域における器官発生の分子制御 (2011)
  • Author(s): 田谷雄二
  • Organizer: 第53回歯科基礎医学会学術大会ならびに総会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2011-10-02
• [Presentation] マウス染色体7C snoRNAクラスター領域からのMBII-52バリアント発現プロファイル (2010)
  • Author(s): 添野雄一、田谷雄二、藤田和也、Alexander Huttenhoffer、青葉孝昭
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 兵庫県、合同大会プログラム
  • Year and Date: 2010-12-08
• [Presentation] マウス染色体7C snoRNAクラスター領域からのMBII-52バリアント発現プロファイル (2010)
  • Author(s): 添野雄一
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
  • Year and Date: 2010-12-08
• [Presentation] A Mouse Model Lacking U50 box C/D-type snoRNA Expression (2010)
  • Author(s): Soeno, Y., Fujita, K., Kudo, T., Taya, Y., and Aoba, T.
  • Organizer: The 15th Annual Meeting of the RNA society
  • Place of Presentation: Seattle, USA
  • Year and Date: 2010-06-24
• [Presentation] A mouse model lacking U50 box C/D-type snoRNA expression (2010)
  • Author(s): Yuuichi SOENO
  • Organizer: The 15th Annual Meeting of the RNA Society
  • Place of Presentation: Seattle, USA
  • Year and Date: 2010-06-24
• [Presentation] Three-dimensional visualization and histomorphometry of developing blood vessel and nerve networks in mouse embryos (2010)
  • Author(s): Yuji TAYA
  • Organizer: 第43回日本発生生物学会年会
  • Place of Presentation: 京都国際会議場(京都府)
  • Year and Date: 2010-06-22
• [Remarks]
• [Remarks]
  • URL: http://www.ndu.ac.jp/~pathhome/
• [Remarks]
  • URL: http://www.ndu.ac.jp/~pathhome/