| Project/Area Number |
22791817
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The Nippon Dental University |
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Principal Investigator |
SOENO Yuuichi 日本歯科大学, 生命歯学部, 講師 (70350139)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 病態病理学 / 歯学 / 病理学 / ノンコーディングRNA / snoRNA / 脳 / 摂食障害 / セロトニン受容体 / RNA-タンパク複合体 |
|---|
| Research Abstract |
While snoRNAs generally mediate the maturation of rRNAs, brain-specific MBII-52 snoRNA has a complementarity to serotonin receptor 2C mRNA. To investigate the not-yet-known function of MBII-52 we analyzed the transcripts and the MBII-52/protein complex in mouse brain. Our results demonstrated that MBII-52 form novel complexes with Nucleolin and ELAVL1, and that some MBII-52 variants are processed into a shorter form according to the nucleotide polymorphism.
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