The effects of autoinducer analog on bacterium related to refractory apical periodontitis.

• Project/Area Number: 22791833
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Osaka University
• Principal Investigator: ASAHI Yoko 大阪大学, 歯学部附属病院, 医員 (50456943)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯学 / バイオフィルム / 阻害薬 / クオラムセンシング / 難治性根尖性歯周炎

Research Abstract

The effects of combined application of an autoinducer analog and antibiotics on Porphyromonas gingivalis were investigated. The combined application of the N-acyl HSL analog and antibiotics was effective at reducing the viability of P. gingivalis cells in biofilms. The effects of the alalog on Fusobacterium nucleatum was also investigated. The analog inhibited F. nucleatum biofilm formation.

Research Products

• [Journal Article] Synergistic effects of antibiotics and an N-acyl homoserine lactone analogue on Porphy romonas gingivalis biofilm (2012)
  • Author(s): Asahi Y, Noiri Y, Igarashi J, Suga H, Azakami H, Ebisu S
  • Journal Title: J Appl Microbiol Volume: 112 Issue: 2 Pages: 404-411
  • DOI: 10.1111/j.1365-2672.2011.05194.x
  • Peer Reviewed
• [Journal Article] Effects of N-acyl homoserine lactone analogues on Porphyromonas gingivalis biofilm formation. (2010)
  • Author(s): Asahi Y., et al.
  • Journal Title: Journal of Periodontal Research Volume: 45 Pages: 255-61
  • Peer Reviewed
• [Presentation] Sub-MICの緑茶カテキンがPorphyromonas gingivalisバイオフィルムに及ぼす影響の検索 (2011)
  • Author(s): 朝日陽子, 野杁由一郎, 前薗葉月, 山本れいこ, 山口幹代, 恵比須繁之
  • Organizer: 第135回日本歯科保存学会
  • Place of Presentation: 大阪国際交流センター(大阪市)
  • Year and Date: 2011-10-20
• [Presentation] Sub-MICの緑茶カテキンがPorphyromonas gingivalisバイオフィルムに及ぼす影響の検索 (2011)
  • Author(s): 朝日陽子
  • Organizer: 第135回日本歯科保存学会
  • Place of Presentation: 大阪国際交流センター(大阪府)
  • Year and Date: 2011-10-20
• [Presentation] Combination chemotherapy using Autoinducer-analog and Antibiotics for Fusobacterium nucleatum Biofilm (2011)
  • Author(s): Asahi Y, Noiri Y, Igarashi J, Maezono H, Ebisu S
  • Organizer: 89th General Session & Exhibition of the IADR
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-03-19
• [Presentation] Inhibition of Porphyromonas gingivalis Biofilm Formation by Synthetic Autoinducer Analogs. (2011)
  • Author(s): Asahi Y., et al.
  • Organizer: 89th General Session & Exhibition of the IADR
  • Place of Presentation: San Diego convention center (California, USA)
  • Year and Date: 2011-03-19
• [Presentation] Combination chemotherapy using Autoinducer-analog and Antibiotics for Porphyromonas gingivalis Biofilm (2010)
  • Author(s): Asahi Y, Noiri Y, Igarashi J, Maezono H, Ebisu S
  • Organizer: 第58回JADR
  • Place of Presentation: 九州歯科大学(北九州市)
  • Year and Date: 2010-11-20
• [Presentation] Combination chemotherapy using Autoinducer-analog and Antibiotics for Porphyromonas gingivalis Biofilm. (2010)
  • Author(s): Asahi Y., et al.
  • Organizer: 58^<th> Japanese Association for Dental Research
  • Place of Presentation: 福岡県北九州市(九州歯科大)
  • Year and Date: 2010-11-20