| Project/Area Number |
22791916
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Research Collaborator |
FUGETSU Bunshi 北海道大学, 地球環境科学研究科(研究院), 教授 (40281844)
TANAKA Saori 北海道大学, 北海道大学病院, 助教 (90344522)
KATO Akihito 北海道大学, 北海道大学病院, 医員 (40507571)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | バイオマテリアル / スキャフォールド / ナノ材料 / リン酸カルシウム / 線維芽細胞増殖因子(FGF2) / ティッシュエンジニアリング / 細胞・組織 / FGF / 歯周組織再生 / 再生医学 / 骨再生 |
|---|
| Research Abstract |
Nanoparticle bioceramics have many bioactive effects. We prepared collagen scaffold coated by nano tricalcium phosphate (TCP) and growth factor and evaluated the effects on tissue engineering. Nano-TCP scaffold showed higher compressive strength, cyto-compatibility and tissue ingrowth. In histological evaluations, bone augmentation and periodontal tissue healing were stimulated by application of nano-TCP scaffold in combination with fibroblast growth factor-2 (FGF2). We concluded that FGF2/nano-TCP scaffold would be effective for bone and periodontal tissue engineering.
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