Development of artificial bone graft materials simulating native bone structure.

• Project/Area Number: 22791926
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka University
• Principal Investigator: SASAKI Jun-ichi 大阪大学, 歯学研究科, 助教 (50530490)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 組織工学 / 生体材料学 / 再生歯学 / 骨再生 / 歯科理工学 / バイオマテリアル / フィブリンゲル / 骨移植材料

Research Abstract

The objective of this study was to develop artificial bone graft materials simulating native bone structure which enabled promotion of functional bone regeneration. We were successful to fabricate novel bone-like materials which contained highly oriented bone matrix. Furthermore, we established a technique to fabricate the bone-cartilage hybrid materials by applying 3D cell construct system. The systems and materials achieved in this study are expected to contribute to advancement of bone regenerative medicine.

Research Products

• [Journal Article] Surface characterization of alkali-and heattreated Ti with or without prior acid etching (2012)
  • Author(s): An SH, Matsumoto T, Miyajima H, Sasaki JI, Narayanan R, Kim KH
  • Journal Title: Applied Surface Science Volume: 258(10) Pages: 4377-4382
  • Peer Reviewed
• [Journal Article] Surface characterization of alkali- and heat-treated Ti with or without prior acid etching (2012)
  • Author(s): An Sang-Hyun
  • Journal Title: Applied Surface Science Volume: 258 Issue: 10 Pages: 4377-4382
  • DOI: 10.1016/j.apsusc.2011.12.119
  • Peer Reviewed
• [Journal Article] Cell-based fabrication of organic/ inorganic composite gel material (2011)
  • Author(s): Matsumoto T, Mizuno A, Kashiwagi M, Yoshida S, Sasaki J, Nakano T
  • Journal Title: Materials Volume: 4(1) Pages: 327-338
  • Peer Reviewed
• [Journal Article] ハイドロゲルを応用した三次元配向組織のin vitro構築 (2011)
  • Author(s): 佐々木淳一、松本卓也、江草宏、矢谷博文
  • Journal Title: 大阪大学歯学会雑誌 Volume: 55(2) Pages: 83-89
  • NAID: 10028161971
• [Journal Article] Cell-based fabrication of organic/inorganic composite gel material (2011)
  • Author(s): 松本卓也
  • Journal Title: Materials Volume: 4 Issue: 1 Pages: 327-338
  • DOI: 10.3390/ma4010327
  • Peer Reviewed
• [Journal Article] ハイドロゲルを応用した三次元配向組織のin vitro構築 (2011)
  • Author(s): 佐々木淳一
  • Journal Title: 大阪大学歯学雑誌 Volume: 55 Pages: 83-89
  • NAID: 10028161971
  • Peer Reviewed
• [Journal Article] Fabrication of 3D cell constructs using temperature-responsive hydrogel (2010)
  • Author(s): Sasaki J, Asoh TA, Matsumoto T, Egusa H, Sohmura T, Alsberg E, Akashi M, Yatani H
  • Journal Title: Tissue Engineering Part A Volume: 16(8) Pages: 2497-2504
  • Peer Reviewed
• [Journal Article] Effect of calcium ion concentrations on osteogenic differenti-ation and hematopoietic stem cell niche-related protein expressions in osteoblasts (2010)
  • Author(s): Nakamura S, Matsumoto T, Sasaki J, Egusa H, Lee KY, Nakano T, Sohmura T, Nakahira A
  • Journal Title: Tissue Engineering Part A Volume: 16(8) Pages: 2467-2473
  • Peer Reviewed
• [Journal Article] In vitro engineering of transitional tissue by patterning and functional control of cells in fibrin gel (2010)
  • Author(s): Sasaki JI, Matsumoto T, Egusa H, Nakano T, Ishimoto T, Sohmura T, Yatani H
  • Journal Title: Soft Matter Volume: 6(8) Pages: 1662-1667
  • Peer Reviewed
• [Journal Article] In vitro engineering of transitional tissue by patterning and functional control of cells in fibrin gel (2010)
  • Author(s): 佐々木淳一
  • Journal Title: Soft Matter Volume: 6 Pages: 1662-1667
  • Peer Reviewed
• [Journal Article] Fabrication of 3D cell constructs using temperature-responsive hydrogel (2010)
  • Author(s): 佐々木淳一
  • Journal Title: Tissue Engineering Part A Volume: 16 Pages: 2497-2504
  • Peer Reviewed
• [Journal Article] Advance in artificial tendons (2010)
  • Author(s): 佐々木淳一
  • Journal Title: Highlights in Chemical Technology Volume: 7 Pages: 2-2
• [Journal Article] Effect of calcium ion concentration on oeteogenic differentiatin and hematopietic stem-cell niche-related protein expressions in osteoblasts (2010)
  • Author(s): 中村真也
  • Journal Title: Tissue Engineering Part A Volume: 16 Pages: 2467-2473
  • Peer Reviewed
• [Presentation] 三次元細胞集合体を利用した内軟骨骨化のin vitro再現 (2011)
  • Author(s): 佐々木淳一、松本卓也、江草宏、矢谷博文、今里聡
  • Organizer: 第33回日本バイオマテリアル学会大会
  • Place of Presentation: 京都市
  • Year and Date: 2011-11-21
• [Presentation] 規骨移植材料の開発を目指した歯肉由来iPS細胞の骨芽細胞分化誘導法の確立 (2011)
  • Author(s): 萱島浩輝、江草宏、佐々木淳一、中野環、矢谷博文
  • Organizer: 第41回日本口腔インプラント学会学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-09-17
• [Presentation] 新規骨移植材料の開発を目指した歯肉由来iPS細胞の骨芽細胞分化誘導法の確立 (2011)
  • Author(s): 萱島浩輝
  • Organizer: 第41回日本口腔インプラント学会学術大会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-09-17
• [Presentation] 小分子化合物を用いた歯肉由来iPS細胞の骨芽細胞分化促進 (2011)
  • Author(s): 萱島浩輝、江草宏、佐々木淳一、裏口真也、于冠男、王放放、福安翔、矢谷博文
  • Organizer: 第120回日本補綴歯科学会学術大会
  • Place of Presentation: 広島市
  • Year and Date: 2011-05-21
• [Presentation] 義歯床用レジンの表面性状はCandida albicansの抗真菌剤感受性に影響を与える (2011)
  • Author(s): 綿本隆生、伊村沙織、佐々木淳一、江草宏、矢谷博文
  • Organizer: 第120回日本補綴歯科学会学術大会
  • Place of Presentation: 広島市
  • Year and Date: 2011-05-21
• [Presentation] 温度応答性ハイドロゲルを用いた三次元細胞集合体の作製 (2011)
  • Author(s): 松本卓也、佐々木淳一、江草宏、麻生隆彬、明石満、今里聡、矢谷博文
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京都
  • Year and Date: 2011-04-30
• [Presentation] 細胞集合体を利用した硬組織生成過程のin vitro再現 (2011)
  • Author(s): 佐々木淳一、松本卓也、江草宏、矢谷博文
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京都
  • Year and Date: 2011-04-30
• [Presentation] Enhanced osteogenesis of gingival fibroblast-derived iPS cells by small molecules (2011)
  • Author(s): Kayashima H, Egusa H, Sasaki J, Yu G, Fukuyasu S, Yatani H
  • Organizer: 89th General Session & Exhibition of the IADR
  • Place of Presentation: San Diego, USA
  • Year and Date: 2011-03-16
• [Presentation] スキャフォールドフリー三次元細胞構造体の作製 (2010)
  • Author(s): 松本卓也、佐々木淳一、江草宏、矢谷博文
  • Organizer: 第56回日本歯科理工学会学術講演会
  • Place of Presentation: 岐阜市
  • Year and Date: 2010-10-09
• [Presentation] スキャフォールドフリー三次元細胞構造体の作製 (2010)
  • Author(s): 松本卓也
  • Organizer: 第56回日本歯科理工学会
  • Place of Presentation: 岐阜県
  • Year and Date: 2010-10-09
• [Presentation] ハイドロゲルを応用した三次元配向組織の構築 (2010)
  • Author(s): 佐々木淳一、松本卓也
  • Organizer: 第110回大阪大学歯学会例会
  • Place of Presentation: 吹田市
  • Year and Date: 2010-07-08
• [Presentation] ハイドロゲルを応用した三次元配向組織の構築 (2010)
  • Author(s): 佐々木淳一
  • Organizer: 大阪大学歯学会第110回例会
  • Place of Presentation: 大阪府(特別講演)
  • Year and Date: 2010-07-08
• [Presentation] 生体骨組織を模倣した細胞配向構造を有する新規骨移植材料 (2010)
  • Author(s): 佐々木淳一、松本卓也、江草宏、荘村泰治、矢谷博文
  • Organizer: 第119回日本補綴歯科学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 2010-06-12
• [Presentation] 生体骨組織を模倣した細胞配向構造を有する新規骨移植材料 (2010)
  • Author(s): 佐々木淳一
  • Organizer: 第119回日本歯科補綴学会
  • Place of Presentation: 東京都
  • Year and Date: 2010-06-12
• [Remarks]
• [Remarks]
  • URL: http://www.dma.jim.osaka-u.ac.jp/kg-portal/aspi/RX0011D.asp?UN0=22542&page=