| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In this study, we focused on the CDX2 gene such as a key gene that induces into hematopoietic stem cells. PDL cells over-expressing CDX2 gene were observed to differentiate into hematopoietic stem-like cells. In addition, we attempted to isolateof hematopoietic stem cells from mouse bone marrow. As a result, the hematopoietic stem cells of Sca-1, CD34, CD45-positive were obtained. These hematopoietic stem cells adhere to type IV collagen, but it does not adhere to type I collagen. Furthermore, hematopoietic stem cells proliferated vigorously by a feeder of mesenchymal stem cells. Elucidation of the induction of angiogenesis is expected by using these cells.
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