The new painless local application of antibiotics by use of iontophoresis with alternative current

• Project/Area Number: 22791958
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: WAKITA Ryo 東京医科歯科大学, 歯学部附属病院, 助教 (60376712)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯科麻酔学 / イオントフォレーシス / 交流 / マイクロダイアリシス / 無痛 / リドカイン / 局所麻酔 / duty cycle

Research Abstract

We have investigated the energized condition for the purpose of antimicrobial drug administration to the intradermal tissue for a long time using an AC iontophoresis. These results indicated that a variable electric field with a DC component were ideal for waveform to be applied and 1% or less concentration of alginate were suitable as the drug retention material. But we also revealed there are advantages in a sine wave and a square wave, respectively. Therefore it is necessary to examine more optimal conditions of iontophoresis using alternating current.

Research Products

• [Journal Article] In vitro evaluation of calcium alginate gels as matrix for iontophoresis electrodes (2012)
  • Author(s): Haida H, Ando S, Ogami S, Wakita R, Kohase H, Saito N, Yoshioka T, Ikoma T, Tanaka J, Umino M, and Fukayama H
  • Journal Title: Journal of Medical and Dental Sciences Volume: 59(1) Pages: 9-16
  • NAID: 130006943990
• [Journal Article] In vitro evaluation of calcium alginate gels as matrix for iontophoresis electrodes. (2012)
  • Author(s): Haida H
  • Journal Title: Journal of Medical and Dental Sciences Volume: 59 Pages: 916-916
  • Peer Reviewed
• [Journal Article] The relation between the duty cycle and anesthetic effect in lidocaine iontophoresis using alternating current (2011)
  • Author(s): Wakita R, Nakajima A, Haida Y, Umino M, Fukayama H
  • Journal Title: Pain Practice Volume: 11(3) Pages: 261-6
• [Presentation] Calcium Alginate gel as electrode material for iontophoresis of lidocaine (2012)
  • Author(s): Ebisawa T
  • Organizer: The 6th International Conference on the Science and Technology for Advanced Ceramics (STAC-6)
  • Place of Presentation: 神奈川
• [Presentation] イオントフォレーシス用電極材料としてのアルギン酸ゲルの有効性 －ラット摘出皮膚の場合－ (2012)
  • Author(s): 海老澤智子
  • Organizer: 第40回日本歯科麻酔学会学術集会
  • Place of Presentation: 福岡
• [Presentation] THE EFFICACY OF IONTOPHORESIS USING THE BIPOLAR SQUARE WAVE WITH DUTYCYCLE (2011)
  • Author(s): R. Wakita, A. Nakajima, H. Haida, H. Fukayama
  • Organizer: the 30th Annual ESRA Congress
  • Place of Presentation: Germany
  • Year and Date: 2011-09-08
• [Presentation] THE EFFICACY OF IONTOPHORESIS USING THE BIPOLAR SQUARE WAVE WITH DUTY CYCLE (2011)
  • Author(s): R.Wakita, A.Nakajima, H.Haida, H.Fukayama
  • Organizer: the 30th Annual ESRA Congress
  • Place of Presentation: Dresden, Germany
  • Year and Date: 2011-09-08
• [Presentation] 交流イオントフォレーシスを用いたリドカイン送達における波形の影響 (2010)
  • Author(s): 中島淳,脇田亮,灰田悠,安藤寧,深山治久
  • Organizer: 第38回日本歯科麻酔学会総会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-10-08
• [Presentation] 交流イオントフォレーシスを用いたリドカイン送達における波形の影響 (2010)
  • Author(s): 中島淳, 脇田亮, 灰田悠, 安藤寧, 深山治久
  • Organizer: 第38回日本歯科麻酔学会総会
  • Place of Presentation: 横須賀、神奈川
  • Year and Date: 2010-10-08
• [Presentation] Electrochemical Deposition of Alginic Acid on Metal Surfaces for theDevelopment of Iontophoresis Electrode (2010)
  • Author(s): N. Saito, T. Yoshioka, T. Ikoma, N.Ohashi, H. Haida, S. Ogami, R. Wakita, H. Kohase, M.Umino and J. Tanaka
  • Organizer: Fourth international conference on the science and technology for advanced ceramics (STAC-4)
  • Place of Presentation: 神奈川
  • Year and Date: 2010-06-21
• [Presentation] Electrochemical Deposition of Alginic Acid on Metal Surfaces for the Development of Iontophoresis Electrode (2010)
  • Author(s): N.Saito, T.Yoshioka, T.Ikoma, N.Ohashi, H.Haida, S.Ogami, R.Wakita, H.Kohase, M.Umino, J.Tanaka
  • Organizer: Fourth international conference on the science and technology for advanced ceramics (STAC-4)
  • Place of Presentation: 横浜、神奈川
  • Year and Date: 2010-06-21