Study of molecular mechanisms of salivary gland development by Snail family genes.

• Project/Area Number: 22791973
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Osaka University
• Principal Investigator: TANIGUCHI Yoshitaka 大阪大学, 歯学研究科, 招聘教員 (10551468)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 唾液腺発達 / Snail / 唾液腺 / 発達 / 分枝発達 / Snailファミリー / Branching / Snaiファミリー

Research Abstract

Snail family genes, snail and slug, which were identified as a epithelial mesenchymal transition, were expressed in epithelial cells of developing salivary glands. We examined the effect of gene-knock down and over-expression of snail family genes on development of salivary gland in explant culture. We found that branching development was inhibited by Snail/ Slug siRNA treatment and stimulated by Snail/ Slug over-expression. These data suggested that Snail and Slug plays stimulatory roles in branching development of salivary gland.