Investigation of the anticancer agent-resistant mechanism and development of the therapeutic method using a transcription factor : YB-1 in the salivary gland cancer
| Project/Area Number |
22791991
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
ONODA Megumi 九州大学, 大学病院, 特別研究員 (90464403)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 唾液腺腫瘍 / 薬剤耐性 / YB-1 / 口腔癌 / 分子標的治療 / 唾液腺癌 / 抗癌剤耐性 |
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| Research Abstract |
YB-1 is known as a transcription factor, which participates in anticancer drug resistance.In this study, I focus to adenoid cystic carcinoma (ACC), because it frequently has anticancer drug resistance. To investigate the function of YB-1 at molecular basis in the anticancer-drug-resistance salivary gland cancer cell, we isolated the associated protein with YB-1 by using the yeast two-hybrid system. Of these proteins, I focused on B23 to understand how YB-1 has involved in stress-response trough the interaction with B23.
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Report
(4 results)
Research Products
(2 results)
