Investigation of the anticancer agent-resistant mechanism and development of the therapeutic method using a transcription factor : YB-1 in the salivary gland cancer

Research Project

Project/Area Number	22791991
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Kyushu University
Principal Investigator	ONODA Megumi 九州大学, 大学病院, 特別研究員 (90464403)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	唾液腺腫瘍 / 薬剤耐性 / YB-1 / 口腔癌 / 分子標的治療 / 唾液腺癌 / 抗癌剤耐性
Research Abstract	YB-1 is known as a transcription factor, which participates in anticancer drug resistance.In this study, I focus to adenoid cystic carcinoma (ACC), because it frequently has anticancer drug resistance. To investigate the function of YB-1 at molecular basis in the anticancer-drug-resistance salivary gland cancer cell, we isolated the associated protein with YB-1 by using the yeast two-hybrid system. Of these proteins, I focused on B23 to understand how YB-1 has involved in stress-response trough the interaction with B23.