Treatment strategy of oral mucosal disease that targeted thecontrol factor SOCS of JAK / STAT
| Project/Area Number |
22791995
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College (2011-2012)
Kyushu University (2010) |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | SOCS,IL23,IL17,TLR / 炎症 / 細菌 / SOCS / IL23 / IL6 / TLR / 癌 / IL-23 / SOCS3 / Th17 / chronic inflammation / LPS / IFNg / JAK-STAT / 粘膜疾患 / STAT / 白板症 / 自然免疫 |
|---|
| Research Abstract |
In this study, we carried out in immunologically-molecularbiological level functional analysis involvement of SOCS to activation of STAT byinflammatory cytokines and collapse of innate immunity via TLR for performing thetreatment of disease of the oral mucosa which is assumed to be caused by failure ofinnate immunity. In particular, it aimed to elucidate control mechanism (leukoplakia,lichen planus) of the oral mucosa diseases caused by cytokines and Th17, Treg, themechanism of pathogenesis in this application. I went to search for associated factorsin Th17, Treg oral cancer, lichen planus, in each oral mucosal disease fromleukoplakia. Upregulation IL6, TNFα, the IL-23 was observed in leukoplakia. ForTh17, Treg, expression RORγt, the Foxp3, was investigated by RT-PCR method ofexpression, GATA3 T-bet further respectively obvious difference was observed. I didnot grasp the obvious feature also localization of Th17. And it will be necessary toconsider further forward.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Variety and complexity offluorine-18-labelled-fluoro-2-deoxy-D-glucose accumulations in the oral cavity ofpatients with oral cancers.2013
Author(s)
Kito S, Koga H, Kodama M, Habu M,Kokuryo S, Yamamoto N, Oda M, NishinoT, Zhang M, Matsuo K, Wakasugi-Sato N,Matsumoto-Takeda S, Seta Y, Yoshiga D,Kaneuji T, Nogami S, Yoshioka I,Yamashita Y, Tanaka T, Miyamoto I,Kitamura C, Tominaga K, Morimoto Y.
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Related Report
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[Journal Article] Weekly teriparatide injectionssuccessfully treated advancedbisphosphonate-related osteonecrosis of thejaws.2013
Author(s)
Yoshiga D, Yamashita Y, Nakamichi I,Tanaka T, Yamauchi K, Yamamoto N,Nogami S, Kaneuji T, Mitsugi S, Sakurai T,Kiyomiya H, Tominaga K, Morimoto Y andTakahashi T.
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Peer Reviewed
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[Journal Article] Magnetic resonanceangiography using fresh blood imagingin oral and maxillofacial regions.2012
Author(s)
Oda M, Tanaka T, Kito S, Habu M,Kodama M, Kokuryo S, Miyamoto I,Yoshiga D, Yamauchi K, Nogami S,Wakasugi-Sato N, Matsumoto-Takeda S,Ishikawa A, Nishida I, Saeki K,Morikawa K, Matsuo K, Seta Y,Yamashita Y, Maki K, Tominaga K,Morimoto Y.
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Journal Title
Int JDent. 2012: 865369. Published online
Related Report
Peer Reviewed
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