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Treatment strategy of oral mucosal disease that targeted thecontrol factor SOCS of JAK / STAT

Research Project

Project/Area Number 22791995
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu Dental College (2011-2012)
Kyushu University (2010)

Principal Investigator

YOSHIGA Daigo  九州歯科大学 (10507784)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsSOCS,IL23,IL17,TLR / 炎症 / 細菌 / SOCS / IL23 / IL6 / TLR / 癌 / IL-23 / SOCS3 / Th17 / chronic inflammation / LPS / IFNg / JAK-STAT / 粘膜疾患 / STAT / 白板症 / 自然免疫
Research Abstract

In this study, we carried out in immunologically-molecularbiological level functional analysis involvement of SOCS to activation of STAT byinflammatory cytokines and collapse of innate immunity via TLR for performing thetreatment of disease of the oral mucosa which is assumed to be caused by failure ofinnate immunity. In particular, it aimed to elucidate control mechanism (leukoplakia,lichen planus) of the oral mucosa diseases caused by cytokines and Th17, Treg, themechanism of pathogenesis in this application. I went to search for associated factorsin Th17, Treg oral cancer, lichen planus, in each oral mucosal disease fromleukoplakia. Upregulation IL6, TNFα, the IL-23 was observed in leukoplakia. ForTh17, Treg, expression RORγt, the Foxp3, was investigated by RT-PCR method ofexpression, GATA3 T-bet further respectively obvious difference was observed. I didnot grasp the obvious feature also localization of Th17. And it will be necessary toconsider further forward.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2013 2012 2011 2010 Other

All Journal Article (37 results) (of which Peer Reviewed: 31 results) Presentation (8 results)

  • [Journal Article] Variety and complexity offluorine-18-labelled-fluoro-2-deoxy-D-glucose accumulations in the oral cavity ofpatients with oral cancers.2013

    • Author(s)
      Kito S, Koga H, Kodama M, Habu M,Kokuryo S, Yamamoto N, Oda M, NishinoT, Zhang M, Matsuo K, Wakasugi-Sato N,Matsumoto-Takeda S, Seta Y, Yoshiga D,Kaneuji T, Nogami S, Yoshioka I,Yamashita Y, Tanaka T, Miyamoto I,Kitamura C, Tominaga K, Morimoto Y.
    • Journal Title

      Dentomaxillofac Radiol.

    • Related Report
      2012 Final Research Report
  • [Journal Article] Occurrence of silk stitch abscess aftersurgery in patients with oral squamous cellcarcinoma.2013

    • Author(s)
      Yamamoto N, Yamashita Y, Yoshiga D
    • Journal Title

      Med Oral Patol Oral Cir Bucal.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased Levels of Interleukin-6 in SynovialLavage Fluid From Patients With MandibularCondyle Fractures: Correlation With MagneticResonance Evidence of Joint Effusion.2013

    • Author(s)
      Nogami S, Takahashi T, Ariyoshi W,Yoshiga D, Morimoto Y, Yamauchi K.
    • Journal Title

      J OralMaxillofac Surg.

      Volume: 71(6) Issue: 6 Pages: 1050-1058

    • DOI

      10.1016/j.joms.2013.01.021

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Weekly teriparatide injectionssuccessfully treated advancedbisphosphonate-related osteonecrosis of thejaws.2013

    • Author(s)
      Yoshiga D, Yamashita Y, Nakamichi I,Tanaka T, Yamauchi K, Yamamoto N,Nogami S, Kaneuji T, Mitsugi S, Sakurai T,Kiyomiya H, Tominaga K, Morimoto Y andTakahashi T.
    • Journal Title

      Osteoporos

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 上顎洞および鼻腔に開窓した巨大な含歯性嚢胞の一例.2013

    • Author(s)
      櫻井拓真・吉賀大午・石川文隆・宮本郁也・野上晋之介・金氏 毅・三次 翔・森本泰宏・山下善弘・高橋 哲
    • Journal Title

      九州歯科学会誌

      Volume: 67(1) Pages: 1-6

    • NAID

      10031174149

    • Related Report
      2012 Final Research Report
  • [Journal Article] 口腔粘膜組織欠損部修復におけるポリグリコール酸フェルトおよびフィブリン糊スプレーの使用経験.2013

    • Author(s)
      野上晋之介、若林奈南子、宮本郁也、吉賀大午、金氏 毅、櫻井拓真、清宮弘康、山本哲彰、山内健介、高橋 哲.
    • Journal Title

      九州歯科学会誌

      Volume: 66(6) Pages: 208-213

    • Related Report
      2012 Final Research Report
  • [Journal Article] 下顎骨関節突起骨折に対する内視鏡を用いた-口内法による観血的整復固定術の経験-2013

    • Author(s)
      吉賀大午・山下善弘・野上晋之介・山本哲彰・山内健介・金氏毅・櫻井拓真・田中達朗・森本泰宏・高橋哲
    • Journal Title

      九州歯科学会誌

      Volume: 66(6) Pages: 198-203

    • NAID

      40019742048

    • Related Report
      2012 Final Research Report
  • [Journal Article] 臼歯腺に生しだ導管内乳頭腫の1例2013

    • Author(s)
      吉賀大午・石川文隆・山下善弘・山本哲彰・山内健介・野上晋之介・片岡良浩・櫻井拓真・森本泰宏・高橋哲
    • Journal Title

      九州歯科学会誌

      Volume: 66(6) Pages: 204-207

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Weekly teriparatide injections successfully treated advanced bisphosphonate-related osteonecrosis of the jaws.2013

    • Author(s)
      Yoshiga D
    • Journal Title

      Osteoporos Int.

      Volume: 31

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Occurrence of silk stitch abscess after surgery in patients with oral squamous cell carcinoma.2013

    • Author(s)
      Yamamoto N
    • Journal Title

      Med Oral Patol Oral Cir Bucal.

      Volume: 18 Pages: 701-705

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Variety and complexity of fluorine-18-labelled-fluoro-2-deoxy-D-glucose accumulations in the oral cavity of patients with oral cancers.2013

    • Author(s)
      Kito S
    • Journal Title

      Dentomaxillofac Radiol.

      Volume: 42 Issue: 7 Pages: 1-8

    • DOI

      10.1259/dmfr.20130014

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of interleukin-6 in synovial lavage fluid from patients with mandibular condyle fractures: correlation with magnetic resonance evidence of joint effusion.2013

    • Author(s)
      Nogami S
    • Journal Title

      Journal of Oral and Maxillofacial Surgery.

      Volume: 71 Pages: 1050-1058

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 当科におけるエプーリス症例、特に骨セメント質形成性エプーリスの病理組織学 的検討2013

    • Author(s)
      古田絢也
    • Journal Title

      九州歯科学会誌

      Volume: 未定

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 上顎洞および鼻腔に開窓した巨大な含歯性嚢胞の一例2013

    • Author(s)
      櫻井拓真
    • Journal Title

      九州歯科学会誌

      Volume: 67 Pages: 1-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔粘膜組織欠損部修復におけるポリグリコール酸フェ ルトおよびフィブリン糊スプレーの使用経験.2013

    • Author(s)
      野上晋之介
    • Journal Title

      九州歯科学会誌

      Volume: 66 Pages: 208-213

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下顎骨関節突起骨折に対する内視鏡を用いた-口内法による観血的整復固定術の経験-2013

    • Author(s)
      吉賀大午
    • Journal Title

      九州歯科学会誌

      Volume: 66 Pages: 198-203

    • NAID

      40019742048

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臼歯腺に生じた導管内乳頭腫の1例2013

    • Author(s)
      吉賀大午
    • Journal Title

      九州歯科学会誌

      Volume: 66 Pages: 204-207

    • NAID

      40019742072

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicalcomparison between the retromandibularapproach for reduction and fixation andendoscope-assisted open reduction andinternal fixation for mandibular condylefractures.2012

    • Author(s)
      Nogami S, Takahashi T, Yamauchi K,Miyamoto I, Kaneuji T, Yamamoto N,Yoshiga D, Yamashita Y.
    • Journal Title

      J Craniofac Surg.

      Volume: 23(6) Issue: 6 Pages: 1815-8

    • DOI

      10.1097/scs.0b013e3182710393

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonanceangiography using fresh blood imagingin oral and maxillofacial regions.2012

    • Author(s)
      Oda M, Tanaka T, Kito S, Habu M,Kodama M, Kokuryo S, Miyamoto I,Yoshiga D, Yamauchi K, Nogami S,Wakasugi-Sato N, Matsumoto-Takeda S,Ishikawa A, Nishida I, Saeki K,Morikawa K, Matsuo K, Seta Y,Yamashita Y, Maki K, Tominaga K,Morimoto Y.
    • Journal Title

      Int JDent. 2012: 865369. Published online

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case ofcoil embolization for unexpectedmassive bleeding caused by internalcarotid artery injury.2012

    • Author(s)
      Fujino H, Ito S, Sugiyama H, Yoshiga D,Karashima Y, Yokoyama T.
    • Journal Title

      Masui

      Volume: 61(3) Pages: 314-317

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case ofadenosquamous carcinoma in theMandibular Gingiva.2012

    • Author(s)
      Mitate E, Oobu K, Yoshiga D, KawanoS, Kawazu T, Kiyoshima T, ToyoshimaT, Kitamura R, Nakamura S.
    • Journal Title

      Journal of JapanSociety for Oral Tumors

      Volume: 24(2) Pages: 55-61

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 口腔悪性腫瘍患者におけるFDG-PET/CTの有用性に関する検討2012

    • Author(s)
      山本哲彰、山内健介、山下善弘、宮本郁也、野上晋之介、吉賀大午、鬼頭慎司、河野辰行、河野憲司、古賀博文、森本泰宏、高橋 哲.
    • Journal Title

      九州歯科学会誌

      Volume: 66(4) Pages: 104-109

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 下唇に発生した小唾液腺体内唾石の1例2012

    • Author(s)
      山本哲彰・吉賀大午・宮本郁也・石川文隆・鬼頭慎司・河野辰行・森本泰宏・河野憲司・高橋哲
    • Journal Title

      九州歯科学会誌

      Volume: 66(4) Pages: 100-103

    • NAID

      10031126309

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臼後部に発生した多形腺腫の1例2012

    • Author(s)
      吉賀大午,川野真太郎,小林家吉,鈴木華子,後藤雄一,中村誠司
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 58(9) Pages: 541-545

    • NAID

      10031144937

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical comparison between the retromandibular approach for reduction and fixation and endoscope-assisted open reduction and internal fixation for mandibular condyle fractures.2012

    • Author(s)
      Nogami S
    • Journal Title

      J Craniofac Surg.

      Volume: 23 Pages: 1815-1818

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance angiography using fresh blood imaging in oral and maxillofacial regions.2012

    • Author(s)
      Oda M
    • Journal Title

      Int J Dent.

      Volume: 2012 Pages: 1-8

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of coil embolization for unexpected massive bleeding caused by internal carotid artery injury.2012

    • Author(s)
      Fujino H
    • Journal Title

      Masui

      Volume: 61 Pages: 314-317

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of adenosquamous carcinoma in the Mandibular Gingiva.2012

    • Author(s)
      Mitate E
    • Journal Title

      Journal of Japan Society for Oral Tumors.

      Volume: 24 Pages: 55-61

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 口腔悪性腫瘍患者におけるFDG-PET/CTの有用性に関する検討2012

    • Author(s)
      山本哲彰
    • Journal Title

      九州歯科学会誌

      Volume: 66 Pages: 104-109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下唇に発生した小唾液腺体内唾石の1例2012

    • Author(s)
      山本哲彰
    • Journal Title

      九州歯科学会誌

      Volume: 66 Pages: 100-103

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臼後部に発生した多形腺腫の1例2012

    • Author(s)
      吉賀大午
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 58 Pages: 541-545

    • NAID

      10031144937

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下顎歯肉に見られた腺扁平上皮癌の1例2012

    • Author(s)
      見立英史
    • Journal Title

      日本口腔腫瘍学会誌

      Volume: 24 Pages: 55-61

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling2011

    • Author(s)
      Kaori Matsumura, Takaharu Taketomi, Keigo Yoshizaki b, Shinsaku Arai a, Terukazu Sanui, Daigo Yoshiga, Akihiko Yoshimura, Seiji Nakamura
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 28 Pages: 1076-82

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative management of a patient with Bernard-Soulier syndrome that has a refractoriness to platelet transfusion2011

    • Author(s)
      Yoshiga D, Yoshida A, Kitahara S, Harada C, Ito S, Nakamura S, Kubo K
    • Journal Title

      Asian Journal of Oral and Maxillofacial Suragery

      Volume: 23 Pages: 102-104

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sprouty2 controls proliferation of palate mesenchymal cells via fibroblast growth factor signaling2010

    • Author(s)
      MATSUMURA K, YOSHIGA D, et al
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 28;404(4) Pages: 1076-82

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zoledronic acid enhanceslipopolysaccharide-stimulatedproinflammatory reactions through controlledexpression of SOCS1 in macrophages.

    • Author(s)
      Muratsu D, Yoshiga D, Taketomi T,Onimura T, Seki Y, Matsumoto A, Nakamura S.Zoledronic acid enhances
    • Journal Title

      PLoSONE.

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 当科におけるエプーリス症例、特に骨セメント質形成性エプーリスの病理組織学的検討

    • Author(s)
      古田絢也、野上晋之介、吉賀大午、金氏 毅、松尾 拡、石川文隆、矢田直美、山内健介、山下善弘、高橋 哲.
    • Journal Title

      九州歯科学会誌

    • NAID

      10031186394

    • Related Report
      2012 Final Research Report
  • [Presentation] 臼歯腺に生じた導管内乳頭腫の1例2012

    • Author(s)
      吉賀大午,石川文隆,山本哲彰,宮本郁也,野上晋之介,片岡良浩,櫻井拓真,高橋哲
    • Organizer
      日本口腔腫瘍学会
    • Place of Presentation
      埼玉
    • Year and Date
      2012-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎関節に生じた偽痛風の1例2012

    • Author(s)
      吉賀大午,石川文隆,宮本郁也,山内健介,山本哲彰,野上晋之介,金氏毅,山下善弘,高橋哲
    • Organizer
      口腔外科学会総会
    • Related Report
      2012 Final Research Report
  • [Presentation] Zoledronic acids enhance lipopolysaccharide-stimulated pro-inflammatory reaction in macrophages2012

    • Author(s)
      D.Yoshiga
    • Organizer
      PER/IADR
    • Place of Presentation
      Helsinki
    • Related Report
      2012 Annual Research Report
  • [Presentation] Zoledronate の TLR4 シグナルを介した自然免疫への関与2012

    • Author(s)
      吉賀大午
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ビスフォスフォネート関連顎骨壊死(BRONJ)に関する臨床的検討2011

    • Author(s)
      吉賀大午, 山本哲彰, 田中謙光, 金氏毅, 宮本郁也, 野上晋之介, 山内健介, 山下善弘, 高橋哲
    • Organizer
      口腔外科学会総会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] RNF135, a RING finger protein, negatively regulates RAS/MAPK signaling2010

    • Author(s)
      YOSHIGA D
    • Organizer
      88th General Session and Exhibition of the IADR
    • Place of Presentation
      Spain
    • Year and Date
      2010-07-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] ZoledoronateがTLR4シグナルを介した炎症反応へ与える影響

    • Author(s)
      村津大地,吉賀大午,武富孝治,鬼村朋宏,中村誠司
    • Organizer
      日本骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Final Research Report
  • [Presentation] Zoledronic acids enhance lipopolysaccharide-stimulated pro-inflammatory reaction

    • Author(s)
      村津大地,吉賀大午,武富孝治,鬼村朋宏,中村誠司
    • Organizer
      macrophages PER/IADR
    • Place of Presentation
      Helsinki
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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