| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In this study, we carried out in immunologically-molecularbiological level functional analysis involvement of SOCS to activation of STAT byinflammatory cytokines and collapse of innate immunity via TLR for performing thetreatment of disease of the oral mucosa which is assumed to be caused by failure ofinnate immunity. In particular, it aimed to elucidate control mechanism (leukoplakia,lichen planus) of the oral mucosa diseases caused by cytokines and Th17, Treg, themechanism of pathogenesis in this application. I went to search for associated factorsin Th17, Treg oral cancer, lichen planus, in each oral mucosal disease fromleukoplakia. Upregulation IL6, TNFα, the IL-23 was observed in leukoplakia. ForTh17, Treg, expression RORγt, the Foxp3, was investigated by RT-PCR method ofexpression, GATA3 T-bet further respectively obvious difference was observed. I didnot grasp the obvious feature also localization of Th17. And it will be necessary toconsider further forward.
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