| Project/Area Number |
22792041
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Orthodontic/Pediatric dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
OHKUMA Mizue 東京医科歯科大学, 歯学部, 非常勤講師 (60456209)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 間葉系細胞 / 転写調節 / TWIST1 / 上皮間葉転換 / DNAメチル化 |
|---|
| Research Abstract |
The bHLH transcription factor TWIST1 plays a crucial role in epithelial mesenchymal transition(EMT). We previously showed a molecular basis for the transcriptional regulation of the TWIST1 gene in mesenchymal cells. In this study, we examined the relation between TWIST1 gene expression in EMT and DNA methylation states at the TWIST1 promoter. In addition, we investigated the molecular mechanism of the transcriptional induction of TWIST1 gene by Tax1 in T cells.
|
