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The role of autophagy in a tooth development

Research Project

Project/Area Number 22792052
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOkayama University

Principal Investigator

YANAGITA Takeshi  岡山大学, 岡山大学病院, 助教 (90534793)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsオートファジー / 発生 / 歯 / 骨組織 / 矯正歯科 / 顎骨
Research Abstract

This study is to be clear the role of autophagy in the process of hard tissue development, especially tooth. At first, we found the difference between tooth development of wild type mouse and that of ATG5 KO(autophagy blocked) mice.
In other hand, we also noticed that the influence of autophagy is larger in bone tissue development rather than tooth development in my experiment process. These results were presented on academic journals and meetings.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (5 results)

  • [Journal Article] Roles of heparan sulfate sulfation in dentinogenesis2012

    • Author(s)
      S Hayano, H Kurosaka, T Yanagita(他10人、3番目)
    • Journal Title

      JBC

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stage-specific embryonic antigen-4 identifies human dental pulp stem cells2012

    • Author(s)
      N Kawanabe, S Murata, T Yanagita(他9人、5番目)
    • Journal Title

      Experimental cell research

      Volume: 318 Pages: 1247-1255

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Core Binding Factor Beta Functions in the Maintenance of Stem Cells and Orchestrates Continuous Proliferation and Differentiation in Mouse Incisors2011

    • Author(s)
      H Kurosaka, Md. N Islam, T Yanagita(他10人、7番目)
    • Journal Title

      STEM CELLS

      Volume: 29 Pages: 1792-1803

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] lass III malocclusion with complex problems of lateral open bite and severe crowding successfully treated with miniscrew anchorage and lingual orthodontic brackets2011

    • Author(s)
      T Yanagita, S Kuroda, T Takano-Yamamoto, T Yamashiro
    • Journal Title

      Am J Orthod Dentofac Orthop

      Volume: 139 Pages: 679-689

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sox9 expression during fracture repair2011

    • Author(s)
      Shintaku Y., Murakami T., Yanagita T., Kawanabe N., Fukunaga T., Matsuzaki K., Uematsu S., Yoshida Y., Kamioka H., Takano-Yamamoto T., Takada K., Yamashiro T
    • Journal Title

      Cells Tissues Organs

      Volume: 194 Issue: 1 Pages: 38-48

    • DOI

      10.1159/000322557

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Class III malocclusion with complex problems of lateral open bite and severe crowding successfully treated with miniscrew anchorage and lingual orthodontic brackets2011

    • Author(s)
      T Yanagita, S Kuroda, T Takano-Yamamoto, T Yamashiro
    • Journal Title

      American Journal of Orthodntics & Dentofacial Orthopedics

      Volume: 139(5) Pages: 679-689

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Core binding factor beta functions in the maintenance of stem cells and orchestrates continuous proliferation and differentiation in mouse incisors2011

    • Author(s)
      Kurosaka H, Islam MN, Kuremoto K, Hayano S, Nakamura M, Kawanabe N, Yanagita T, Rice DP, Harada H, Taniuchi I, Yamashiro T
    • Journal Title

      Stem Cells

      Volume: 29巻 Issue: 11 Pages: 1792-1803

    • DOI

      10.1002/stem.722

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sox9 expression during fracture repair

    • Author(s)
      Shintaku Y
    • Journal Title

      Cells Tissues Organs

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Class III malocclusion with complex problems of lateral open bite and severe crowding successfully treated using miniscrew anchorage and lingual orthodontic brackets

    • Author(s)
      Takeshi Yanagita
    • Journal Title

      American Journal of Orthodontics and Dentofacial Orthopedics

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨形成におけるオートファジーの関与2011

    • Author(s)
      中村政裕
    • Organizer
      先端歯学スクール
    • Place of Presentation
      神奈川
    • Year and Date
      2011-09-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 象牙質形成におけるWntシグナリングとヘパラン硫酸の糖残基修飾2011

    • Author(s)
      早野暁
    • Organizer
      第70回日本矯正歯科学会
    • Place of Presentation
      愛知
    • Related Report
      2011 Final Research Report
  • [Presentation] 象牙質形成におけるWntシグナリングとヘパラン硫酸の糖残基修飾2011

    • Author(s)
      早野暁、黒坂寛、富田奈緒、柳田剛志、川邊紀章、Thomas Dierks、Ina Kalus、山城隆
    • Organizer
      第70回日本矯正歯科学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヘパラン硫酸の糖残基修飾は象牙質形成に関与する2010

    • Author(s)
      早野暁
    • Organizer
      第69回 日本矯正歯科学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 岡山大学病院矯正歯科における来院患者の実態調査2010

    • Author(s)
      白賀のり子
    • Organizer
      第69回 日本矯正歯科学会
    • Place of Presentation
      横浜
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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