Research of the implantation method of the mixture of growth factor to increase the amount of periodontal tissue regeneration of horizontal bone defect
| Project/Area Number |
22792078
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Emiko 北海道大学, 大学院・歯学研究科, 助教 (80374528)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周外科学 / BMP / ｂＦＧＦ-2 / 水平性骨欠損 / 多層移植法 / 二層移植法 / 歯周組織再生 / bone morphogenetic protein / basic fibroblast growth factor / ハニカム構造 / βTCP / bFGF |
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| Research Abstract |
This study investigated the effect of the combination of BMP and FGF, and the effect of structure of carrier used when the growth factor was implanted with the aim of increase of periodontal regeneration. A tunnel pipe structure having an inner diameter of 300μm induced an increase in cells and blood vessels derived from the residual bone into carrier and the bone defects, and that the amount of the bone regeration increased. This studysuggested that the structure to conduct the vessel invasion was important. Additionally, the new bone formation and cementum formation of the multi-layer implantation method consisting of both BMP-2-containing carrier and bFGF-2-containing carrier were larger than that of the complex implantation method of BMP-2 and bFGF-2 and BMP-2 or bFGF-2 only implantation method. The aberrant healing like ankylosis was inhibited, too. From the above results, thisstudy suggested that implantation method of the multi-layer using both BMP-2-containingcarrier and bFGF-2-containing carrier could enhance periodontal regeneration.
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Report
(4 results)
Research Products
(39 results)
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[Presentation] Effect of tunnel pipe structure of bone grafts onregeneration.2010
Author(s)
Akira Saito, Emiko Saito, Yoshinori Kuboki, Yoshitaka Yoshimura, Dairo Takahashi, Yoshiyuki Honma, Hiroko Takita, Mariko Takayama, Ryohei Handa ,Keishi Honma, Noboru Ohata
Organizer
IADR 88th GeneraSession
Place of Presentation
バルセロナインターナショナルコンベンションセンター,スペイン.
Related Report
