Factors for secretion disorder of salivary gland with mouse salivary gland progenitor cell and iPS cell

• Project/Area Number: 22792084
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Okayama University
• Principal Investigator: MINESHIBA Junji 岡山大学, 岡山大学病院, 講師 (00509383)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 唾液腺分泌障害 / 唾液腺幹細胞 / 唾液腺再生 / マウス唾液腺幹細胞 / マウスiPS細胞 / 分化のコントロール

Research Abstract

We found that the extracellular humoral factors secreted by CD49f-positive cells would be potential progenitor cells related to regeneration of salivary glands. Inhibin β_A, Inhibin β_B, and Follistatin may relate to the proliferation of progenitor cells in salivary glands

Research Products

• [Presentation] 唾液腺の機能的再生は可能か? (2013)
  • Author(s): 峯柴 淳二
  • Organizer: 第1回先端医学研究会at OU
  • Place of Presentation: 岡山県岡山市
  • Year and Date: 2013-03-30
• [Presentation] Salivary Gland Progenitor Cells Express Inhibin βA, and Inhibin βB (2013)
  • Author(s): A. IKEDA, (J. MINESHIBA)
  • Organizer: The 91st International Association for Dental Research
  • Place of Presentation: Seattle,USA
  • Year and Date: 2013-03-20
• [Presentation] iPS細胞を使って唾液腺再生の鍵となる因子を探す (2013)
  • Author(s): 峯柴 淳二
  • Organizer: 岡山大学サイエンスカフェ「iPS細胞の原理と将来」
  • Place of Presentation: 岡山県岡山市
  • Year and Date: 2013-02-04
• [Presentation] Salivary Gland Progenitor Cells Express Inhibin βA, and Inhibin βB (2013)
  • Author(s): A. IKEDA, ( J. MINESHIBA )
  • Organizer: The 91st International Association for Dental Research
  • Place of Presentation: Seattle，USA
• [Presentation] 唾液腺の機能的再生は可能か？ (2013)
  • Author(s): 峯柴 淳二
  • Organizer: 第１回先端医学研究会at OU
  • Place of Presentation: 岡山県岡山市
• [Presentation] 抗菌ペプチド遺伝子の唾液腺への導入による口腔感染予防 (2012)
  • Author(s): 峯柴 淳二
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2012-11-10
• [Presentation] マウス顎下腺上皮細胞の細胞外液性因子がiPS細胞に与える影響 (2012)
  • Author(s): 池田淳史、 (峯柴淳二
  • Organizer: 第136回日本歯科保存学会春季学術大会
  • Place of Presentation: 沖縄県宜野湾市
  • Year and Date: 2012-06-29