Research Project
Grant-in-Aid for Young Scientists (B)
The aim of this study is investigation of redox regulation in periodontal tissue to use antioxidative stress mechanism(Keap1-Nrf2 system) as new periodontitis prevention and treatment. This study show Porphyromonas gingivalis(p. g.) LPS induced oxidative stress and the antioxidant response in human gingival fibroblast. keratinocyte growth factor(KGF) induced antioxidative enzyme(HO-1) and antioxidant response-transcriptional factor(Nrf2) expressions. KGF may enhance antioxidative stress mechanism in periodontal tissue.
All 2012 2011 2010
All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (3 results)
J Periodont Res
Volume: (in press) Issue: 4 Pages: 488-499
10.1111/j.1600-0765.2011.01458.x
Volume: (in press) Issue: 5 Pages: 554-652
10.1111/j.1600-0765.2011.01466.x
Arch Oral Biol
Volume: 56 Pages: 761-767
http://www.ncbi.nlm.nih.gov/pubmed/21316034
Immunology and Cell Biology
Volume: 88 Pages: 328-333
http://www.nature.com/icb/journal/v88/n3/full/icb2009104a.html