Analysis of the effects of MK615 for anti-inflammation and inhibition of bone destruction : The novel possibility of prevention for periodontal disease.

• Project/Area Number: 22792094
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Kagoshima University
• Principal Investigator: MORIMOTO Youko 鹿児島大学, 医学部・歯学部附属病院, 助教 (30437967)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯周病 / MK615 / 抗炎症 / 骨吸収抑制 / 破骨前駆細胞 / 骨破壊抑制 / サイトカイン / 歯周病原菌 / LPS / MAPKs

Research Abstract

Focused on the anti-inflammatory effect of MK615(an extract of compounds from Japanese apricot), we were analyzed the inhibitory effect of MK615 for inflammatory cytokine production under LPS stimulation of periodontal pathogenic bacteria, the effect of inhibiting bone destruction, in this study. As a result, production of cytokines such as TNF-α, IL-6 and IL-8 from macrophage-like cells and gingival fibroblasts is suppressed in a dose-dependent manner of MK615, it should be due to inhibition of the pathway MAPKs/NF-κB has been shown. In addition, it was also shown that the inhibition of osteoclast differentiation from osteoclast progenitor cells by the addition of MK615.

Research Products

• [Journal Article] MK615 : A new therapeutic approach for the treatment of oral disease (2011)
  • Author(s): Yoko Morimoto-Yamashita, Miki Matsuo, Hitoshi Komatsuzawa, Ko-ic hi Kawahara, Kiyoshi Kikuchi, Mits uo Torii, Masayuki Tokuda
  • Journal Title: Medical Hypotheses Volume: 77 Pages: 258-260
  • URL: http://www.sciencedirect.com/science/article/pii/S0306987711001903
  • Peer Reviewed
• [Journal Article] エンドウェーブ^<TM>システムによる弯曲根管へのポイントの適合性 (2011)
  • Author(s): 川上克子, 徳田雅行, 山下-森元陽子, 梶原武弘, 藤澤真理, 宮下桂子, 江本真規子, 鳥居光男
  • Journal Title: 日本歯科保存学雑誌 Volume: 54(5) Pages: 341-345
  • Peer Reviewed
• [Journal Article] Beneficial Effects of the Free Radical Scavenger Edaravone(Radicut) in Neurologic Diseases (2011)
  • Author(s): Kiyoshi Kikuchi, Naoki Miura, Yoko Morimoto, Takashi Ito, Salunya Tancharoen, Kei Miyata, Chiemi Kikuchi, Narumi Iida, Nobuyuki Takeshige, Hisaaki Uchikado, Naohisa Miyagi, Naoto Shiomi, Terukazu Kuramoto, Teruto Hashiguchi, Ikuro Maruyama, Motohiro Morio
  • Journal Title: J Neurol Neurophysiol Volume: 1 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Beneficial Effects of the Free Radical Scavenger Edaravone (Radicut) in Neurologic Diseases (2011)
  • Author(s): Kikuchi K, Morimoto Y, et al
  • Journal Title: J Neurology and Neurophysiology Volume: 1 Pages: 1-5
  • Peer Reviewed
• [Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGB1-induced apoptosis in ischemic neuronal injury in PC12 cells (2010)
  • Author(s): Kiyoshi Kikuchi, Ko-ichi Kawahara, Hisaaki Uchikado, Naohisa Miyagi, Terukazu Kuramoto, Tomoya Miyagi, Yoko Morimoto, Salunya Tancharoen, Naoki Miura, Teruto Hashiguchi, Ikuro Maruyama, Takashi Tokutomi, and Minoru Shigemori
  • Journal Title: Neurotraumatology Volume: 33(2) Pages: 241-243
  • NAID: 10031136426
  • Peer Reviewed
• [Journal Article] HMGB1 : A new marker for estimation of the postmortem interval (2010)
  • Author(s): Kiyoshi Kikuchi, Ko-ichi Kawahara, Kamal Krishna Biswas, Takashi Ito, Salunya Tancharoen, Naoto Shiomi, Yoshiro Koda, Fumiyo Matsuda, Yoko Morimoto, Yoko Oyama, Kazunori Takenouchi, Naoki Miura, Noboru Arimura, Yuko Nawa, Shinichiro Arimura, Xiaojie Meng
  • Journal Title: Experimental and Therapeutic Medicine Volume: 1(1) Pages: 109-111
  • URL: http://www.spandidos-publications.com/etm/1/1/109
  • Peer Reviewed
• [Journal Article] Edaravone : a new therapeutic approach for the treatment of acute stroke (2010)
  • Author(s): Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Shigemori M.
  • Journal Title: Medical Hypotheses Volume: 75(6) Pages: 583-585
  • URL: http://www.sciencedirect.com/science/article/pii/S0306987710002859
  • Peer Reviewed
• [Journal Article] Post mortem contrast-enhanced computed tomography in a case of sudden death from acute pulmonary thromboembolism (2010)
  • Author(s): Kiyoshi Kikuchi, Ko-Ichi Kawahara, Chiyoko Tsuji, Yutaka Tajima, Terukazu Kuramoto, Miwako Shihara, Yukari Koga, Naoto Shiomi, Hisaaki Uchikado, Yoko Morimoto, Naoki Miura, Kentaro Mera, Yoshiko Ohno, Naohisa Miyagi, Teruto Hashiguchi, Ikuro Maruyama, Nao
  • Journal Title: Experimental and Therapeutic Medicine Volume: 1(3) Pages: 503-505
  • URL: http://www.spandidos-publications.com/etm/1/3/503
  • Peer Reviewed
• [Journal Article] Edaravone : a new therapeutic approach for the treatment of acute stroke. (2010)
  • Author(s): Kikuchi K, Morimoto Y, et al.
  • Journal Title: Medical Hypotheses. Volume: 75 Pages: 583-585
  • Peer Reviewed
• [Journal Article] HMGB1 : A new marker for estimation of the postmortem interval. (2010)
  • Author(s): Kikuchi K, Morimoto Y, et al.
  • Journal Title: Experimental and Therapeutic Medicine. Volume: 1 Pages: 109-111
  • Peer Reviewed
• [Presentation] 歯周病と糖尿病の病態ネットワークにおけるHMGB1の関与 (2011)
  • Author(s): 森元陽子、徳田雅行、鳥居光男
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 山口県,下関市
  • Year and Date: 2011-09-24
• [Presentation] 歯周病と糖尿病の病態ネットワークにおけるHMGB1の関与 (2011)
  • Author(s): 森元陽子、徳田雅行、鳥居光男
  • Organizer: 第54回日本歯周病学会秋季学術大会
  • Place of Presentation: 山口県(下関市)
  • Year and Date: 2011-09-24
• [Presentation] MK615 attenuates P. gingivalis lipopolysaccharide-induced IL-6 release in RAW264. 7 cells (2010)
  • Author(s): Yoko Morimoto-Yamashita, Masayuki Tokuda, Mitsuo Torii
  • Organizer: 96^<th> AAP annual meeting
  • Place of Presentation: アメリカ、ハワイ
  • Year and Date: 2010-11-01
• [Presentation] MK615 attenuates P.gingivalis lipopolysaccharide-induced IL-6 release in RAW264.7 cells. (2010)
  • Author(s): Yoko Morimoto-Yamashita, et al.
  • Organizer: 96^<th> AAP annual meeting
  • Place of Presentation: アメリカ合衆国(ハワイ)
  • Year and Date: 2010-11-01
• [Presentation] MK615 attenuates P. gingivalis lipopolysaccharide-induced TNF-τrelease in RAW264. 7 cells (2010)
  • Author(s): Yoko Morimoto-Yamashita, Masayuki Tokuda, Mitsuo Torii
  • Organizer: 88^<th> General Session and Exhibition of the IADR
  • Place of Presentation: スペイン、バルセロナ
  • Year and Date: 2010-07-15
• [Presentation] MK615 attenuates P.gingivalis lipopolysaccharide-induced TNF-α release in RAW264.7 cells. (2010)
  • Author(s): Yoko Morimoto-Yamashita, et al.
  • Organizer: 88^<th> General Session and Exhibition of the IADR
  • Place of Presentation: スペイン(バルセロナ)
  • Year and Date: 2010-07-15
• [Book] Pathogenesis and Treatment of periodontitis Japanese apricot (Ume) : A novel therapeutic approach for the treatment of periodontitis (2012)
  • Author(s): Yoko Morimoto-Yamashita, et al
  • Publisher: INTECH OPEN ACCESS PUBLISHER
• [Book] Periodontal Disease : Symptoms, T reatment and Prevention. HMGB1 : A Novel Inflammatory Mediator in Chronic Periodontitis (2011)
  • Author(s): Yoko Morimoto-Yamashita, Masayuki Tokuda, Kiyoshi Kikuchi, Ikuro Maruyama, Mitsuo Torii, and Ko-ichi Kawahara
  • Publisher: NOVA Publishers
  • URL: https://www.novapublishers.com/catalog/product_info.php?products_id=24242
• [Book] 梅肉抽出エキスMK615は歯周病抑制に効果あり (2011)
  • Author(s): 森元陽子、徳田雅行、鳥居光男
  • Publisher: 鹿児島県歯科医師会会報
• [Book] Periodontal Disease : Symptoms, Treatment and Prevention.(Chapter 13- HMGB1 : A Novel Inflammatory Mediator in Chronic Periodontitis.) (2011)
  • Author(s): Yoko Morimoto-Yamashita, et al.
  • Publisher: NOVA Publishers
• [Remarks]
  • URL: https://www.novapublishers.com/catalog/product_info.php?products_id=24242