Search and application of peptides which interrupt several periodontopathic oral colonization mechanisms widely
| Project/Area Number |
22792115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
IWASAKI Mio 大阪大学, 歯学部附属病院, 医員 (70570290)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 予防歯科学 / GAPDH / ペプチド / 歯周病細菌 / 感染 |
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| Research Abstract |
In this study, it was found that the binding site in human cellular glyceraldehydes-3-phosphate dehydrogenase(GAPDH) for P. gingivalis fimbriae exists in the same domain as in oral bacterial GAPDH. It was suggested that the peptide synthesized based on the amino acid sequence corresponding to the binding site might be applicable as an inhibitory agent against P. gingivalis colonization in oral cavity.
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Report
(3 results)
Research Products
(10 results)
