| Project/Area Number |
22810009
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Nanomaterials/Nanobioscience
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ANRAKU Yasutaka 東京大学, 大学院・工学系研究科, 特任研究員 (60581585)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,042,000 (Direct Cost: ¥2,340,000、Indirect Cost: ¥702,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,534,000 (Direct Cost: ¥1,180,000、Indirect Cost: ¥354,000)
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| Keywords | 自己組織化中空粒子 / ドラッグデリバリーシステム / 弾性率 / 体内動態 / DDS / 架橋率 / 血中滞流性 / 腫瘍集積性 / 自己組織化 / 中空粒子 / ベシクル / 生体内デリバリー / バイオマテリアル / DDSキャリア |
|---|
| Research Abstract |
We have previously demonstrated interesting properties in spontaneously formed submicron-sized polyion complex vesicles(Nano-PICsomes) via the self-assembly of a pair of oppositely charged polymers, whereby cross-linking of the PIC membrane by a condensation reagent can control many properties, including improvement of blood circulation and biodistribution. In this time, we succeeded in the characterization and in vivo evaluation of Nano-PICsomes with various cross-linking ratios and sizes.
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