Modeling and experimental analysis of Gene Regulatory Networks of the ascidian CNS

• Project/Area Number: 22870018
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Kyoto University
• Principal Investigator: SATOU Kaoru 京都大学, 大学院・理学研究科, 助教 (00447921)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: 転写 / ネットワーク / 発生

Research Abstract

Systematic gene disruption assays by morpholino oligonucleotide injection provided gene circuit diagrams for each cells in the Ascidian CNS. Based on this gene regulatory network, I constructed a model for the mechanism of transcription in Ascidian CNS.

Research Products

• [Journal Article] Genomic cis-regulatory networks in the early Ciona intestinalis embryo (2010)
  • Author(s): A. Kubo, N. Suzuki, X. Yuan, K. Nakai, N. Satoh, K. S. Imai and Y Satou
  • Journal Title: Development Volume: 137 Issue: 10 Pages: 1613-1623
  • DOI: 10.1242/dev.046789
  • Peer Reviewed
• [Journal Article] Genomic cis-regulatory networks in the early Ciona intestinalis embryo (2010)
  • Author(s): 久保純, 等
  • Journal Title: Development Volume: 137 Pages: 1613-1623
  • Peer Reviewed
• [Presentation] Pinhead functions as a negative regulator of ADMPin Ciona intestinalis (2011)
  • Author(s): Imai, K. S. and Satou, Y. Pinhead
  • Organizer: 第82回日本動物学会
  • Place of Presentation: 旭川
  • Year and Date: 2011-09-21
• [Presentation] ユウレイボヤにおいてBMPシグナリングを阻害する新規分泌蛋白pinの機能解析 (2011)
  • Author(s): 佐藤薫
  • Organizer: 日本動物学会第82回大会
  • Place of Presentation: 大雪クリスタルホール(旭川市)
  • Year and Date: 2011-09-21
• [Presentation] Pinhead functions as a negative regulator of ADMPin Ciona intestinalis (2011)
  • Author(s): Imai, K. S. and Satou, Y. Pinhead
  • Organizer: 2nd joint meeting of the French and British Societies for Developmental Biology
  • Place of Presentation: ニース
  • Year and Date: 2011-09-04
• [Presentation] Pin functions as a negative regulator of BMP signaling (2011)
  • Author(s): Imai, K. S
  • Organizer: The 4th International Symposium of the Biodiversity and Evolution Global COE project
  • Place of Presentation: 京都
  • Year and Date: 2011-07-09
• [Remarks]
  • URL: http://gcoe.biol.sci.kyoto-u.ac.jp/gcoe/index_j.php
• [Remarks]
  • URL: http://gcoe.biol.sci.kyoto-u.ac.jp/gcoe/index_j.php