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The association between the life event of women such as menarche, labor and menopause, and incidence of hypertension and other lifestyle-related diseases.

Research Project

Project/Area Number 22890017
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Public health/Health science
Research InstitutionTohoku University

Principal Investigator

METOKI Hirohito  東北大学, 大学院・医学系研究科, 助教 (20580377)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Keywords高血圧 / 妊娠高血圧 / 女性医学 / 薬剤反応性 / 月経周期 / 血圧変動
Research Abstract

We observed effects of blood pressure from childbirth events of women. Blood pressure in clinic situation was significantly higher in primipara compared with multiparous woman. However, there were no significant differences in home blood pressure between primipara and multiparous women. These results support out-of-office blood pressure based on ambulatory blood pressure measurement showed no significant differences among primipara and multiparous women.
Evaluation based on blood pressure measurement only in clinical setting might overestimate blood pressure in primipara, therefore, out-of-office blood pressure monitoring might important to evaluate the association between the life event of women such as menarche, labor and menopause, and incidence of hypertension and other lifestyle-related diseases.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (28 results)

All 2012 2011 2010

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (11 results) Book (4 results)

  • [Journal Article] the BOSHI Study Group. Daily serial hemodynamic data during pregnancy and seasonal variation : the BOSHI study2012

    • Author(s)
      Metoki H, Ohkubo T, Obara T, Akutsu K, Yamamoto M, Ishikuro M, Sakurai K, Iwama N, Katagiri M, Sugawara J, Hirose T, Sato M, Kikuya M, Yagihashi K, Matsubara Y, Yaegashi N, Mori S, Suzuki M, Imai Y
    • Journal Title

      Clin Exp Hypertens

      Volume: (In press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure changes during pregnancy2012

    • Author(s)
      Ishikuro M, Obara T, Metoki H, Ohkubo T, Yaegashi N, Kuriyama S, Imai Y
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 563-564

    • NAID

      10030645980

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Daily serial hemodynamic data during pregnancy and seasonal variation : the BOSHI study2012

    • Author(s)
      Metoki H, et al
    • Journal Title

      Clinical Experimental Hypertension

      Volume: (未定)(In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood pressure changes during pregnancy2012

    • Author(s)
      Ishikuro M, Obara T, Metoki H, Ohkubo T, Yaegashi N, Kuriyama S, Imai Y.
    • Journal Title

      Hypertens Res

      Volume: 35 Issue: 5 Pages: 563

    • DOI

      10.1038/hr.2012.33

    • NAID

      10030645980

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aldosterone-to-renin ratio and nocturnal blood pressure decline in a general population : the Ohasama study2011

    • Author(s)
      Satoh M, Kikuya M, Ohkubo T, Mori T, Metoki H, Hashimoto T, Hara A, Utsugi MT, Hirose T, Obara T, Inoue R, Asayama K, Kanno A, Totsune K, Hoshi H, Satoh H, Imai Y
    • Journal Title

      J Hypertens

      Volume: 29 Pages: 1940-1947

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 妊娠前後における女性のサプリメント摂取BOSHI研究2011

    • Author(s)
      原梓、目時弘仁, ら
    • Journal Title

      医薬品相互作用研究

      Volume: 34 Pages: 145-149

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal blood pressure variation and cardiovascular prognosis in a community-based study of Ohasama, Japan2010

    • Author(s)
      Metoki H, Ohkubo T, Imai Y
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 652-656

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease : the Ohasama study2010

    • Author(s)
      Kanno A, Metoki H, Kikuya M, Terawaki H, Hara A, Hashimoto T, Asayama K, Inoue R, Shishido Y, Nakayama M, Totsune K, Ohkubo T, Imai Y
    • Journal Title

      Hypertens Res

      Volume: 33 Pages: 1192-1198

    • NAID

      10027476176

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of environmental tobacco smoke exposure with elevated home blood pressure in Japanese women : the Ohasama study2010

    • Author(s)
      Seki M, Inoue R, Ohkubo T, Kikuya M, Hara A, Metoki H, Hirose T, Tsubota-Utsugi M, Asayama K, Kanno A, Obara T, Hoshi H, Totsune K, Satoh H, Imai Y
    • Journal Title

      J Hypertens

      Volume: 28 Pages: 1814-1820

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of assessing masked and white-coat hypertension by ambulatory blood pressure monitoring for determining prevalent risk of chronic kidney disease : the Ohasama study.2010

    • Author(s)
      Kanno A, Metoki H, et al.
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 1192-1198

    • NAID

      10027476176

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accumulation of common polymorphisms is associated with development of hypertension : a 12-year follow-up from the Ohasama study.2010

    • Author(s)
      Watanabe Y, Metoki H, et al.
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 129-134

    • NAID

      10026126289

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Parental longevity and offspring's home blood pressure : the Ohasama study.2010

    • Author(s)
      Watanabe Y, Metoki H, et al.
    • Journal Title

      Journal of Hypertension

      Volume: 28 Pages: 272-277

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal blood pressure variation and cardiovascular prognosis in a community-based study of Ohasama, Japan.2010

    • Author(s)
      Metoki H, et al.
    • Journal Title

      Hypertension Research

      Volume: 33 Pages: 652-656

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 妊娠中Pulse Wave Velocity(PWV)と妊娠高血圧症候群(PIH)及び家庭血圧推移との関連:BOSHI研究2011

    • Author(s)
      阿久津好美、目時弘仁, 他
    • Organizer
      第32回日本妊娠高血圧学会
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 24時間自由行動下血圧・家庭血圧と脳血管障害2011

    • Author(s)
      目時弘仁, 他
    • Organizer
      第32回日本妊娠高血圧学会
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 妊娠期間中血圧推移と妊婦の母親の妊娠期間中血圧レベルとの関連:BOSHI研究2011

    • Author(s)
      目時弘仁, 他
    • Organizer
      第34回日本高血圧学会
    • Place of Presentation
      宇都宮
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 妊娠期間中の収縮期血圧・心拍数・ダブルプロダクト・ショックインデックス値の推移と季節変動:BOSHI研究2011

    • Author(s)
      目時弘仁, 他
    • Organizer
      第13回時間循環血圧管理研究
    • Place of Presentation
      東京
    • Year and Date
      2011-07-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 妊娠期間中の収縮期血圧・心拍数・ダブルプロダクト・ショックインデックス値の推移と季節変動:BOSHI研究2011

    • Author(s)
      目時弘仁, ら
    • Organizer
      第13回時間循環血圧管理研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-07-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] 喫煙・受動喫煙と妊娠期間中の血圧推移:BOSHI 研究2010

    • Author(s)
      目時弘仁, 他
    • Organizer
      第31回日本妊娠高血圧学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 喫煙・受動喫煙と妊娠期間中の血圧推移:BOSHI研究2010

    • Author(s)
      目時弘仁, 他
    • Organizer
      第31回日本妊娠高血圧学会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Smoking, passive smoking and home blood pressure values during pregnancy : the BOSHI study2010

    • Author(s)
      Metoki H, et al
    • Organizer
      第17回国際妊娠高血圧学会
    • Place of Presentation
      メルボルン
    • Year and Date
      2010-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Smoking, passive smoking and home blood pressure values duringpregnancy : the BOSHI study.2010

    • Author(s)
      Metoki H, et al.
    • Organizer
      17th The International Society for the Study of Hypertension in Pregnancy(ISSHP)World Congress
    • Place of Presentation
      メルボルン(オーストラリア)
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Decreased mid pregnancy fall in home blood pressure in relation to insulin resistance : the BOSHI study2010

    • Author(s)
      Kawaguchi M, Metoki H, et al
    • Organizer
      第20回欧州高血圧会議
    • Place of Presentation
      オスロ
    • Year and Date
      2010-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Decreased mid pregnancy fall in home blood pressure in relation to insulin resistance : the BOSHI study.2010

    • Author(s)
      Kawaguchi M, Metoki H, et al.
    • Organizer
      20th European Meeting on Hypertension
    • Place of Presentation
      オスロ(ノルウェー)
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Book] 家庭血圧測定とその有用性, 産婦人科治療2011

    • Author(s)
      目時弘仁、八重樫伸生、今井潤
    • Related Report
      2011 Final Research Report
  • [Book] 産婦人科治療:家庭血圧測定とその有用性2011

    • Author(s)
      目時弘仁、八重樫伸生、今井潤
    • Publisher
      永井書店
    • Related Report
      2010 Annual Research Report
  • [Book] 5. 大迫研究家庭血圧の重要性を証明-遺伝子解析の結果-BIO Clinica, ゲノム疫学の研究2010

    • Author(s)
      目時弘仁、今井潤
    • Publisher
      北隆館
    • Related Report
      2011 Final Research Report
  • [Book] BIO Clinica:ゲノム疫学の研究 5.大迫研究 家庭血圧の重要性を証明-遺伝子解析の結果-2010

    • Author(s)
      目時弘仁、今井潤
    • Publisher
      北隆館
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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