Regulation of nuclear receptor Nurr1 by stress-responsive signaling

• Project/Area Number: 22890031
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: The University of Tokyo
• Principal Investigator: SEKINE Yusuke 東京大学, 大学院・薬学系研究科, 特任研究員 (00583981)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: ストレス / シグナル伝達 / 核内受容体 / ASK1 / p38 / Nurr1 / ドパミン神経細胞 / パーキンソン病

Research Abstract

A nuclear receptor, Nurr1, plays critical roles for development of dopaminergic neurons as a transcription factor. In this study, I found that, in response to oxidative stress, Nurr1 was phosphorylated through the p38 MAP kinase pathway and was exported from nucleus to cytosol. These results suggest that Nurr1 has potential roles other than transcription factor in oxidative stress response

Research Products

• [Journal Article] Prevention of apoptosis by mitochondrial phosphatase PGAM5 in the mushroom body is crucial for heat shock resistance in Drosophila melanogaster (2012)
  • Author(s): Ishida, Y., et al.
  • Journal Title: PloS ONE Volume: 7 Issue: 2 Pages: 3006-3016
  • DOI: 10.1371/journal.pone.0030265
  • Peer Reviewed
• [Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors (2011)
  • Author(s): Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
  • Journal Title: J. Cell Sci. Volume: 124 Issue: 17 Pages: 3006-3016
  • DOI: 10.1242/jcs.085902
  • Peer Reviewed
• [Journal Article] ストレスシグナルによるアポトーシス制御と癌形成における役割 (2011)
  • Author(s): 関根悠介, 武田弘資, 一條秀憲
  • Journal Title: 実験医学増刊,羊土社 Volume: 29 Pages: 222-228
• [Journal Article] ストレスシグナルによるアポトーシス制御と癌形成における役割 (2011)
  • Author(s): 関根悠介、武田弘資、一條秀憲
  • Journal Title: 実験医学増刊 Volume: 29 Pages: 222-228
• [Journal Article] 哺乳類細胞のストレス受容・伝達機構とそれに起因する疾患 (2010)
  • Author(s): 畑中良, 関根悠介, 一條秀憲
  • Journal Title: 化学と生物,学会出版センター Volume: 48 Pages: 471-477
  • NAID: 10026875538
• [Journal Article] 哺乳類細胞のストレス受容・伝達機構とそれに起因する疾患 (2010)
  • Author(s): 畑中良、関根悠介、一條秀憲
  • Journal Title: 化学と生物 Volume: 48 Pages: 471-477
  • NAID: 10026875538
• [Presentation] ストレス応答キナーゼによる酸化ストレス応答と細胞死 (2011)
  • Author(s): 関根悠介,一條秀憲
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館
• [Presentation] Roles of the kelch repeat protein KLHDC10 in oxidative stress-induced ASK1 activation (2011)
  • Author(s): Sekine Y., Hatanaka, R., Watanabe, T., Mosallanejad, K., Takeda, K. and Ichijo, H
  • Organizer: 13th International TNF Conference
  • Place of Presentation: Awaji Yumebutai International Conference Center
• [Presentation] Roles of the kelch repeat protein KLHDC10 in oxidative stress-induced ASK1 activation (2011)
  • Author(s): Sekine Y., Hatanaka, R., Watanabe, T., Takeda, K. and Ichijo, H
  • Organizer: 1^<st> Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Roles of the Kelch repeat protein KLHDC10 in oxidative stress-induced ASK1 activation (2011)
  • Author(s): Sekine, Y., et al.
  • Organizer: 13th International TNF Conference (TNF2011)
  • Place of Presentation: 淡路島夢舞台国際会議場
• [Presentation] Roles of the Kelch repeat protein KLHDC10 in oxidative stress-induced ASK1 activation (2011)
  • Author(s): Sekine, Y., et al.
  • Organizer: 1st Asia-Pacific Drosophila Research Conference
  • Place of Presentation: Taipei, Taiwan
• [Presentation] 酸化ストレス依存的なASK1活性制御機構におけるKLHDC10の役割 (2010)
  • Author(s): 関根悠介
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 酸化ストレス依存的なASK1活性制御機構におけるKLHDC10の役割 (2010)
  • Author(s): 関根悠介,武田弘資,一條秀憲
  • Organizer: BMB2010(第83回日本生化学会大会・第33回日本分子生物学会年会合同大会)
  • Place of Presentation: 神戸ポートアイランド