Regulation of nuclear receptor Nurr1 by stress-responsive signaling
| Project/Area Number |
22890031
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
SEKINE Yusuke 東京大学, 大学院・薬学系研究科, 特任研究員 (00583981)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
|
|---|
| Keywords | ストレス / シグナル伝達 / 核内受容体 / ASK1 / p38 / Nurr1 / ドパミン神経細胞 / パーキンソン病 |
|---|
| Research Abstract |
A nuclear receptor, Nurr1, plays critical roles for development of dopaminergic neurons as a transcription factor. In this study, I found that, in response to oxidative stress, Nurr1 was phosphorylated through the p38 MAP kinase pathway and was exported from nucleus to cytosol. These results suggest that Nurr1 has potential roles other than transcription factor in oxidative stress response
|
Report
(3 results)
Research Products
(13 results)
-
-
[Journal Article] p38 MAP kinase regulates the expression of genes in the dopamine synthesis pathway through phosphorylation of NR4A nuclear receptors2011
Author(s)
Sekine,Y., Takagahara,S., Hatanaka, R., Watanabe, T., Oguchi, H., Noguchi, T., Naguro, I., Kobayashi, K., Tsunoda, M., Funatsu, T., Nomura, H., Toyoda, T., Matsuki, N., Kuranaga, E., Miura, M., Takeda, K., and Ichijo, H.
-
Journal Title
J. Cell Sci.
Volume: 124
Issue: 17
Pages: 3006-3016
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
