| Project/Area Number |
22890032
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Tokyo Women's Medical University (2011)
The University of Tokyo (2010) |
|---|
Principal Investigator |
IMAE Rieko 東京女子医科大学, 医学部, 助教 (60584000)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
|
|---|
| Keywords | 非対称分裂 / ホスホイノシチド |
|---|
| Research Abstract |
Intracellular phospholipase A1(ipla-1) and acyltransferases(acl-8, acl-9 and acl-10) determine the sn-1 fatty acyl chain of phosphatidylinositol(PI) in C. elegans. In both ipla-1 mutants and acl-8 acl-9 acl-10 triple mutants, the sn-1 fatty acid composition of PI is significantly altered, and asymmetric division of stem cell-like epithelial cells is defective. This study identified the molecules that are associated with the asymmetric division defects caused by the altered fatty acid composition of PI. In addition, functional conservation of acl-8,-9,-10 in mammals was examined.
|
