Functional role of reactive oxygen species in hematopoiesis

• Project/Area Number: 22890042
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: SHINOHARA Akihito 東京大学, 医学部・付属病院, 助教 (70579713)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 活性酸素 / 造血幹細胞 / 造血前駆細胞 / 造血細胞分化 / CSF1R / 造血 / シグナル伝達

Research Abstract

While reactive oxygen species(ROS) have been known as harmful substances, it has been noted recently that ROS are critical mediators in cellular homeostasis. In this study, we revealed that intracellular ROS level of megakaryocyte-erythrocyte progenitor cells(MEP) was kept low. Furthermore, we revealed that ROS inhibited the generation of MEP. This study indicates the importance of ROS in hematopoiesis and the possibility that control of ROS is useful for effective generation of blood cells.

Research Products

• [Presentation] A critical role of reactive oxygen species in the generation of megakaryocyte-erythrocyte progenitor cells (2010)
  • Author(s): 篠原明仁
  • Organizer: 52ndAmericanSocietyofHematologyAnnualMeetingandExposition
  • Place of Presentation: Orange County Convention Center, Orland, USA
  • Year and Date: 2010-12-04
• [Presentation] A Critical Role of Reactive Oxygen Species In the Generation of Megakaryocyte-Erythrocyte Progenitor Cells (2010)
  • Author(s): 篠原明仁
  • Organizer: The 2010 Annual Meeting of the American Society of Hematology
  • Place of Presentation: オーランドフロリダ州米国
  • Year and Date: 2010-12-04
• [Presentation] 造血前駆細胞の系統決定における活性酸素の役割 (2010)
  • Author(s): 篠原明仁
  • Organizer: 第72回日本血液学会学術集会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2010-09-24
• [Presentation] 造血前駆細胞の系統決定における活性酸素の役割 (2010)
  • Author(s): 篠原明仁
  • Organizer: 日本血液学会
  • Place of Presentation: 横浜
  • Year and Date: 2010-09-24
• [Presentation] 骨髄球系前駆細胞の分化における活性酸素の役割 (2010)
  • Author(s): 篠原明仁
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] 骨髄球系前駆細胞の分化における活性酸素の役割 (2010)
  • Author(s): 篠原明仁
  • Organizer: 日本癌学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] A critical role of reactive oxygen species in the generation of megakaryocyte-erythrocyte progenitor cells (2010)
  • Author(s): 篠原明仁
  • Organizer: 第1回日本血液学会国際シンポジウム
  • Place of Presentation: 秋田大学(秋田県)
  • Year and Date: 2010-07-16