The roles of DRR1 in tumorigenesis and nerve system

• Project/Area Number: 22890080
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Pathological medical chemistry
• Research Institution: Nagoya University
• Principal Investigator: MU Ping 名古屋大学, 大学院・医学系研究科, 助教 (10584675)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: 腫瘍抑制 / 神経発生 / DRR1

Research Abstract

After the overexpression of DRR1 in neuroblastoma cells, cell growth was decreased. Downregulation of DRR1 in NB39 cells inhibited low serum induced cell differentiation. The result of RT-PCR showed that the expression of DRR1 increased after differentiation induction in tumor sphere. In primary cultured hippocampal neurons, DRR1 located in both dendrite and axon. And after downregulation of DRR1 in hippocampal neuron, the length of neurite was decreased when compared to control. These results showed the possibility that DRR1 affect neuroblastoma cell growth by regulating cell's differentiation.

Research Products

• [Journal Article] The Neuronal Differentiation Factor NeuroD1 Downregulates the Neuronal Repellent Factor Slit2 Expression and Promotes Cell Motility and Tumor Formation of Neuroblastoma (2011)
  • Author(s): Peng Huang, Satoshi Kishida, Dongliang Cao, Yuko Murakami-Tonami, Ping Mu, Masato Nakaguro, Naoshi Koide, Ichiro Takeuchi, Akira Onishi, and Kenji Kadomatsu
  • Journal Title: Cancer Res Volume: 71(8) Pages: 2938-48
  • Peer Reviewed
• [Journal Article] The Neuronal Differentiation Factor NeuroD1 Downregulates the Neuronal Repellent Factor Slit2 Expression and Promotes Cell Motility and Tumor Formation of Neuroblastoma (2011)
  • Author(s): Peng Huang, Satoshi Kishida, Dongliang Cao, Yuko Murakami-Tonami, Ping Mu, Masato Nakaguro, Naoshi Koide, Ichiro Takeuchi, Akira Onishi, Kenji Kadomatsu
  • Journal Title: Cancer Research Volume: 71 Issue: 8 Pages: 2938-48
  • DOI: 10.1158/0008-5472.can-10-3524
  • Peer Reviewed
• [Journal Article] DRR1 is expressed in the developing nervous system and downregu lated during neuroblastoma carcinogenesis (2010)
  • Author(s): Asano Y, Kishida S, Mu P, Sakamoto K, Murohara T, Kadomatsu K
  • Journal Title: Biochem Biophys Res Commun Volume: 124 Pages: 2978-90
  • Peer Reviewed
• [Presentation] 神経系におけるDRR1の役割の解析 (2011)
  • Author(s): 牟萍
  • Organizer: 日本神経科学学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-14