New tuberculosis lipid antigen vaccine using rhesus infection model.

• Project/Area Number: 22890091
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Infectious disease medicine
• Research Institution: Kyoto University
• Principal Investigator: KUWATA Hirotaka 京都大学, ウイルス研究所, 助教 (60380523)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 免疫学 / 微生物学 / 感染症 / 細菌

Research Abstract

New development for anti-TB vaccination based on lipid chemistry has been eagerly expected. Mycobacterial mycolates were evaluated and confirmed for their ability to induce specific responses as therapeutic agents in Rhesus macaque vaccine model. As the results, mycolates augmented the specific induction of IFN-gamma from lymphocyte derived from peripheral blood. Taken together, it is validated that Mycobacterium mycolate can be a strong candidate for anti TB vaccination.

Research Products

• [Journal Article] A microbial glycolipid functions as a new class of target antigen for delayed-type hypersensitivity. (2011)
  • Author(s): Komori T, Nakamura T, Matsunaga I, Morita D, Hattori Y, Kuwata H, Fujiwara N, Hiromatsu K, Harashima H, Sugita M.
  • Journal Title: J Biol Chem. Volume: 286 Pages: 13-13
• [Journal Article] Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. (2011)
  • Author(s): Jaqaman K, Kuwata H, Touret N, Collins R, Trimble WS, Danuser G, Grinstein S.
  • Journal Title: Cell Pages: 146-146
• [Journal Article] Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function (2011)
  • Author(s): Jaqaman K*, Kuwata H*, et al. (*Equal contribution.)
  • Journal Title: Cell Volume: Vol.146, 4 Issue: 4 Pages: 593-606
  • DOI: 10.1016/j.cell.2011.06.049
  • Peer Reviewed
• [Presentation] Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. (2011)
  • Author(s): 桑田啓貴, Grinstein S.
  • Organizer: 第40回日本免疫学会学術集会
  • Year and Date: 2011-11-27
• [Presentation] 細胞骨格によるスカベンジャー受容体CD36重合体形成とシグナルの制御機構Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function (2011)
  • Author(s): 桑田啓貴
  • Organizer: 日本免疫学会総会
  • Place of Presentation: 千葉市、幕張メッセ
  • Year and Date: 2011-11-27