| Project/Area Number |
22890115
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
NAKAYAMA Masaaki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10579105)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周病原細菌 / Porphyromonas gingivalis / 破骨細胞分化 / 自然免疫 / 抗酸菌 / Toll-like receptor |
|---|
| Research Abstract |
In this study, we demonstrated whether P. gingivalis affects osteoclastogenesis induced by RANK/RANKL signaling. Osteoclastic precursor cells were challenged by P. gingivalis with RANKL at the same time, analyzed its differentiation for matured osteoclasts. Interestingly, the osteoclastic precursors were inhibited RANK/RANKL-induced osteoclastogenesis by infection of P. gingivalis. It was, however, contratory to my expectation that osteoclasts were promoted to form the large number of matured cells and activated bone resorption by P. gingivalis infection. According to investigate this inhibition by using precursor cells from knockout mice of TLRs and adaptor factors, MyD88 and TRIF, it revealed that innate immune response through TLR2/MyD88 signaling pathway were related with this inhibition.
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