The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells
| Project/Area Number |
22890119
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
YAMASHIRO Keisuke 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30581087)
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| Research Collaborator |
YAMAMOTO Tadashi 岡山大学, 病院, 講師 (50432662)
TAKASHIBA Shogo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯肉上皮細胞 / TGF-β / インテグリン / 細胞外基質 / Smad2 / Aggregatibacter actinomycetemcomitans / 細胞接着因子 / 細胞外マトリックス / Aggregatibacter ac / フィブロネクチン / Actinobacillus actinomycetemcomitans / 細胞接着 / E-cadherin / 細胞増殖 |
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| Research Abstract |
Periodontal disease, chronic inflammation disease, is caused by infection of periodontal pathogen. It is thought that about 80% of Japanese are affected and it is a major cause of tooth loss. It is still unknown that the difference of progression of periodontal disease for each patient. It is thought that the attachment between gingival epithelial cells and tooth is a physical barrier from infection, and this attachment is important for prevention of periodontal disease. In this study, we hypothesis that growth factors secretes from gingival epithelial cells regulate the attachment between gingival epithelial cells and tooth, and we investigate the mechanism about the regulation.
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Report
(3 results)
Research Products
(5 results)
