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The molecular biological analysis of the mechanism for cell adhesion mediated by growth factor in human gingival epithelial cells

Research Project

Project/Area Number 22890119
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionOkayama University

Principal Investigator

YAMASHIRO Keisuke  岡山大学, 大学院・医歯薬学総合研究科, 助教 (30581087)

Research Collaborator YAMAMOTO Tadashi  岡山大学, 病院, 講師 (50432662)
TAKASHIBA Shogo  岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000)
Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯肉上皮細胞 / TGF-β / インテグリン / 細胞外基質 / Smad2 / Aggregatibacter actinomycetemcomitans / 細胞接着因子 / 細胞外マトリックス / Aggregatibacter ac / フィブロネクチン / Actinobacillus actinomycetemcomitans / 細胞接着 / E-cadherin / 細胞増殖
Research Abstract

Periodontal disease, chronic inflammation disease, is caused by infection of periodontal pathogen. It is thought that about 80% of Japanese are affected and it is a major cause of tooth loss. It is still unknown that the difference of progression of periodontal disease for each patient. It is thought that the attachment between gingival epithelial cells and tooth is a physical barrier from infection, and this attachment is important for prevention of periodontal disease. In this study, we hypothesis that growth factors secretes from gingival epithelial cells regulate the attachment between gingival epithelial cells and tooth, and we investigate the mechanism about the regulation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2011 Other

All Presentation (4 results) Remarks (1 results)

  • [Presentation] Aggregatibacter actinomycetemcomitansがヒト歯肉上皮細胞の細胞接着因子に及ぼす影響2011

    • Author(s)
      高知信介, 山城圭介
    • Organizer
      平成23年度秋季日本歯科保存学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Aggregatibacter actinomycetemcomitansがヒト歯肉上皮細胞の細胞接着因子に及ぼす影響2011

    • Author(s)
      高知信介
    • Organizer
      日本歯科保存学会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯肉上皮細胞において外因性Smad2は細胞接着分子の発現を促進する2011

    • Author(s)
      本郷昌一, 山城圭介
    • Organizer
      第54回秋季日本歯周病学会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯肉上皮細胞において外因性Smad2は細胞接着分子の発現を促進する2011

    • Author(s)
      本郷昌一
    • Organizer
      日本歯周病学会
    • Place of Presentation
      山口県下関市
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cc.okayama-u.ac.jp/~perio/bind2/index.html

    • Related Report
      2011 Final Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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