The regulation of insulin signaling by caveolin through modulating reactive oxygen species.

• Project/Area Number: 22890151
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Metabolomics
• Research Institution: Yokohama City University
• Principal Investigator: OSHIKAWA Jin 横浜市立大学, 医学部, 助教 (50381471)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 糖尿病 / インスリンシグナル / シグナル伝達 / 酸化ストレス

Research Abstract

Although it has been reported that caveolin proteins promote the activity of insulin signaling, its mechanisms are not fully determined. In this study, caveolin-3 enhanced the activity of insulin receptor through PTP1B which is regulated by reactive oxygen species. We will examine this mechanism in detail using diabetic animal model.

Research Products

• [Journal Article] Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells. (2012)
  • Author(s): Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 302
• [Journal Article] Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells (2012)
  • Author(s): Oshikawa J
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 302号
  • Peer Reviewed
• [Journal Article] The role of caveloae, lipid rafts and caveolin in insulin signaling (2010)
  • Author(s): Oshikawa J, Toya Y, Umemura S, Ishikawa Y
  • Journal Title: Trends in Cell Mol Biol Volume: 5 Pages: 23-33
• [Presentation] p66Shc, a Longevity Adaptor Protein, is Involved in ROS-dependent Activation of VEGF recetor 2 and AMP kinase (2011)
  • Author(s): Kim SJ, Urao N, Oshikawa J, Caliceti C, Furuta E, Chen GF, McKinney RD, Fukai T, Ushio-Fukai M
  • Organizer: Role in VEGF-induced Energy Metabolism and Angiogenesis. Scientific Sessions of American Heart Association 2011
  • Place of Presentation: New Orleans, LA USA.
  • Year and Date: 2011-11-16
• [Presentation] Role of Extracellular Superoxide Dismutase, Copper Transporter ATP7A and Caveolae/lipid rafts in Endothelial Dysfunction in Type I Diabetic Mice (2010)
  • Author(s): Varadarajan S, Urao N, Oshikawa J, McKinney RD, Ushio-Fukai M, Fukai T
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2010-11-16
• [Presentation] p66shc Mediates VEGF Receptor Signaling Linked to Production of ROS from Mitochondria and NO from AMPK-eNOS Involved in Endothelial Cell Migration and Proliferation (2010)
  • Author(s): Caliceti C, Oshikawa J, Razvi M, Urao N, McKinney RD, Fukai T, Ushio-Fukai M
  • Organizer: Scientific Sessions of American Heart Association 2010
  • Place of Presentation: Chicago, IL USA
  • Year and Date: 2010-11-15