Molecular analyses and clinical application of a novel oncogene, SMYD2 in gastrointestinal cancers.

• Project/Area Number: 22890158
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: KOMATSU Shuhei 京都府立医科大学, 医学研究科, 助教 (40578978)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: 分子生化学 / 分子標的 / 癌遺伝子 / 分子生物学

Research Abstract

Previously, we detected the novel cancer-related gene, SMYD2(SET and MYND domain-containing protein 2) as a novel amplification target of 1q32-41 in esophageal squamous cell carcinoma(Komatsu S et al. Carcinogenesis 2009). In this study, we demonstrated the molecular mechanisms and clinical significance of SMYD2 in gastrointestinal cancers, especially in gastric carcinoma.

Research Products

• [Journal Article] Prognostic impact of circulating miR-21 and miR-375 in plasma of patients with esophageal squamous cell carcinoma (2012)
  • Author(s): Komatsu S, Ichikawa D
  • Journal Title: Expert Opin Biol Ther Volume: 12 Issue: sup1 Pages: S53-S59
  • DOI: 10.1517/14712598.2012.681373
  • Peer Reviewed
• [Journal Article] Circulating microRNA in digestive tract cancers (2012)
  • Author(s): Ichikawa D, Komatsu S
  • Journal Title: Gastroenterology Volume: 142 Issue: 5 Pages: 1074-1078
  • DOI: 10.1053/j.gastro.2012.03.008
  • Peer Reviewed
• [Journal Article] Novel diagnostic value of circulatingmiR-18a in plasma of patients with pancreatic cancer (2011)
  • Author(s): Morimura R, Ichikawa D
  • Journal Title: Br J Cancer Volume: 105 Issue: 11 Pages: 1733-1740
  • DOI: 10.1038/bjc.2011.453
  • Peer Reviewed
• [Journal Article] Circulating microRNAs in plasma of patients with oesophageal squamous cell carcinoma (2011)
  • Author(s): Komatsu S, Ichikawa D
  • Journal Title: Br J Cancer Volume: 105 Issue: 1 Pages: 104-111
  • DOI: 10.1038/bjc.2011.198
  • Peer Reviewed
• [Journal Article] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma. (2010)
  • Author(s): Haruki S, Komatsu S, et al.
  • Journal Title: Carcinogenesis Volume: 31 Pages: 1017-36
  • Peer Reviewed
• [Journal Article] Prediction of CCND1 amplification using plasma DNA as a prognostic marker in oesophageal squamous ell carcinoma. (2010)
  • Author(s): Takeshita H, Komatsu S, et al.
  • Journal Title: British Journal of Cancer Volume: 27 Pages: 1378-83
  • Peer Reviewed
• [Journal Article] Circulating microRNAs in plasma of patients with gastric cancers. (2010)
  • Author(s): Tsujiura M, Komatsu S, et al.
  • Journal Title: British Journal of Cancer Volume: 102 Pages: 1174-9
  • Peer Reviewed
• [Presentation] 食道癌扁平上皮癌の増幅領域の再評価により同定した新しい癌関連遺伝子SMYD2の癌化機構の解明と臨床応用 (2010)
  • Organizer: 日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2010-04-08
• [Presentation] 食道癌扁平上皮癌の増幅領域の再評価により同定した新しい癌関連遺伝子SMYD2の癌化機構の解明と臨床応用 (2010)
  • Author(s): 小松周平
  • Organizer: 日本外科学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2010-04-08