Quantitative Evaluation of Carotid Plaque Characteristics by using Color-Coded High-Contrast Magnetic Resonance Imaging

• Project/Area Number: 22890169
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Iwate Medical University
• Principal Investigator: NARUMI Shinsuke 岩手医科大学, 医学部, 助教 (20583644)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,821,000 (Direct Cost: ¥2,170,000、Indirect Cost: ¥651,000); Fiscal Year 2011: ¥1,222,000 (Direct Cost: ¥940,000、Indirect Cost: ¥282,000); Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
• Keywords: MRI / プラークイメージング / 頸部頸動脈狭窄症 / 頸動脈内膜剥離術 / シロスタゾール / 神経科学

Research Abstract

We attempted to establish a quantitative method to characterize intraplaque components by using high-contrast plaque imaging technique and color-coded analysis software which we developed. This method can readily differentiate intraplaque components with excellent sensitivities and specificities as compared with other techniques, particularly when using the color-coded software ; and can detect subtle changes in intraplaque composition during cilostazol therapy. This method thus is considered to be promising for accurate and quantitative assessment of intraplaque composition.

Research Products

• [Journal Article] Quantitative assessment of changes in carotid plaques during cilostazol administration using three-dimensional ultrasonography and non-gated magnetic resonance plaque imaging (2012)
  • Author(s): Yamaguchi M, Sasaki M, Ohba H, Mori K, Narumi S, et al.
  • Journal Title: Neuroradiology
  • Peer Reviewed
• [Journal Article] Carotid plaque signal differences among four kinds of T1-weighted magnetic resonance imaging techniques : a histopathological correlation study (2012)
  • Author(s): Saito A, Sasaki M, Ogasawara K, Kobayashi M, Hitomi J, Narumi S, et al.
  • Journal Title: Neuroradiology
  • Peer Reviewed
• [Journal Article] Prediction of carotid plaque characteristics using non-gated magnetic resonance imaging : correlation with endarterectomy specimens (2012)
  • Author(s): Narumi S, Sasaki M, Ohba H, et al.
  • Journal Title: AJNR Volume: (in press)
  • Peer Reviewed
• [Journal Article] Quantitative assessment of changes in carotid plaques during cilostazol administration using three-dimensional ultrasonography and non-gated magnetic resonance plaque imaging (2012)
  • Author(s): Yamaguchi M, et al
  • Journal Title: Neuroradiology Volume: 54 Issue: 9 Pages: 939-945
  • DOI: 10.1007/s00234-012-1011-2
  • Peer Reviewed
• [Journal Article] Carotid plaque signal differences among four kinds of T1-weighted magnetic resonance imaging techniques : A histopathological correlation study (2012)
  • Author(s): Saito A, et al
  • Journal Title: Neuroradiology Volume: (online) Issue: 11 Pages: 1187-94
  • DOI: 10.1007/s00234-012-1025-9
  • Peer Reviewed
• [Journal Article] Prediction of Carotid Plaque Characteristics Using Non-Gated Magnetic Resonance Imaging : Correlation with Endarterectomy Specimens (2012)
  • Author(s): Narumi S, et al
  • Journal Title: American Journal of Neuroradiology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Altered Carotid Plaque Signal among Different Repetition Times on T1-Weighted Magnetic Resonance Plaque Imaging (2011)
  • Author(s): Shinsuke Narumi, et al
  • Journal Title: Neuroradiology Volume: 52 Pages: 285-290
  • Peer Reviewed
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラーク性状の予測:病理標本との比較 (2011)
  • Author(s): 鳴海新介, 他.
  • Organizer: 第39回日本磁気共鳴医学会
  • Place of Presentation: 小倉
  • Year and Date: 2011-09-29
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラーク性状の予測:病理標本との比較 (2011)
  • Author(s): 鳴海新介
  • Organizer: 日本磁気共鳴医学会
  • Place of Presentation: 小倉
  • Year and Date: 2011-09-29
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラーク性状の予測-頸動脈超音波検査との比較- (2011)
  • Author(s): 鳴海新介, 他.
  • Organizer: 第36回日本脳卒中学会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-31
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラーク性状の予測-頸動脈超音波検査との比較- (2011)
  • Author(s): 鳴海新介
  • Organizer: 日本脳卒中学会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-31
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラーク性状の予測-頸動脈超音波検査との比較- (2011)
  • Author(s): 鳴海新介, 他.
  • Organizer: 第30回日本脳神経超音波学会
  • Place of Presentation: 長崎
  • Year and Date: 2011-07-08
• [Presentation] 心電図非同期MRプラークイメージングによる頚動脈プラーク性状の予測-頸動脈超音波検査との比較- (2011)
  • Author(s): 鳴海新介
  • Organizer: 日本脳神経超音波学会
  • Place of Presentation: 長崎
  • Year and Date: 2011-07-08
• [Presentation] Prediction of carotid plaque characteristics by using non-gated magnetic resonance imaging : correlation with end-arterectomy specimens (2011)
  • Author(s): Narumi S, et al.
  • Organizer: European Stroke Conference 2011
  • Place of Presentation: Hamburg
  • Year and Date: 2011-05-25
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラークの性状の予測-頸動脈超音波検査との比較- (2010)
  • Author(s): 鳴海新介, 他.
  • Organizer: 第38回日本磁気共鳴医学会
  • Place of Presentation: 筑波
  • Year and Date: 2010-10-01
• [Presentation] MRプラークイメージングを用いたシロスタゾール投与における頸動脈プラークの経時的変化の検討 (2010)
  • Author(s): 山口真央
  • Organizer: 第38回磁気共鳴医学会
  • Place of Presentation: エポカル筑波
  • Year and Date: 2010-10-01
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラークの性状の予測:頸動脈超音波検査との比較 (2010)
  • Author(s): 鳴海新介
  • Organizer: 第38回磁気共鳴医学会
  • Place of Presentation: つくば国際会議場(つくば)
  • Year and Date: 2010-10-01
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラークの性状の予測-頸動脈超音波検査との比較- (2010)
  • Author(s): 鳴海新介, 他.
  • Organizer: 第29回日本脳神経超音波学会
  • Place of Presentation: 岡山
  • Year and Date: 2010-07-09
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラークの性状の予測:頸動脈超音波検査との比較 (2010)
  • Author(s): 鳴海新介
  • Organizer: 第29回日本脳神経超音波学会
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2010-07-09
• [Presentation] Prediction of carotid plaque characteristics by using non-gated magnetic resonance plaque imaging with self-navigated radial-scan technique : correlation with histology of endarterectomy specimens (2010)
  • Author(s): Narumi S, et al.
  • Organizer: European Stroke Conference 2010
  • Place of Presentation: Barcelona
  • Year and Date: 2010-05-26
• [Presentation] MRプラークイメージングの撮像条件の最適化-プラーク性状判定能の改善に向けて- (2010)
  • Author(s): 鳴海新介, 他
  • Organizer: 第35回日本脳卒中学会
  • Place of Presentation: 盛岡
  • Year and Date: 2010-04-16
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラークの性状の予測:頸動脈超音波検査との比較 (2010)
  • Author(s): 鳴海新介
  • Organizer: 第35回日本脳卒中学会
  • Place of Presentation: 盛岡グランドホテル(盛岡)
  • Year and Date: 2010-04-16
• [Presentation] 心電図非同期MRプラークイメージングによる頸動脈プラークの性状の予測:頸動脈超音波検査との比較 (2010)
  • Author(s): 鳴海新介
  • Organizer: European stroke conference 2010
  • Place of Presentation: palau de congressos de Catalunya