| Project/Area Number |
22890171
|
|---|
| Research Category |
Grant-in-Aid for Research Activity Start-up
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
USUI Fumitake 自治医科大学, 医学部, ポストドクター (50585560)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,834,000 (Direct Cost: ¥2,180,000、Indirect Cost: ¥654,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
|
|---|
| Keywords | 循環器 / メタボリック症候群 / 炎症 / 自然免疫 |
|---|
| Research Abstract |
In recent years, much attention has been paid to findings that involvement of chronic inflammation in the lifestyle-related diseases, such as hyperlipidemia, obesity, diabetes, and hypertension. In this study, we attempted to elucidate the role of inflammasome which is known to be involved in sterile inflammation in the lifestyle-related diseases. Inflammasome contributes to the development of atherosclerosis and angiotensin II-induced aortic aneurysm. Inflammasome is expected to become a therapeutic target for lifestyle-related diseases to clarify the mechanism.
|
