Role of NLRP3 inflammasomes in the metabolic syndrome.

• Project/Area Number: 22890171
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Circulatory organs internal medicine
• Research Institution: Jichi Medical University
• Principal Investigator: USUI Fumitake 自治医科大学, 医学部, ポストドクター (50585560)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,834,000 (Direct Cost: ¥2,180,000、Indirect Cost: ¥654,000); Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000); Fiscal Year 2010: ¥1,365,000 (Direct Cost: ¥1,050,000、Indirect Cost: ¥315,000)
• Keywords: 循環器 / メタボリック症候群 / 炎症 / 自然免疫

Research Abstract

In recent years, much attention has been paid to findings that involvement of chronic inflammation in the lifestyle-related diseases, such as hyperlipidemia, obesity, diabetes, and hypertension. In this study, we attempted to elucidate the role of inflammasome which is known to be involved in sterile inflammation in the lifestyle-related diseases. Inflammasome contributes to the development of atherosclerosis and angiotensin II-induced aortic aneurysm. Inflammasome is expected to become a therapeutic target for lifestyle-related diseases to clarify the mechanism.

Research Products

• [Journal Article] Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice (2012)
  • Author(s): Usui F, Kimura H, Ohshiro T, Tatsumi K, Kawashima A, Nishiyama A, Iwakura Y, Ishibashi S, Takahashi M
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 420 Pages: 72-77
• [Journal Article] Interleukin-17 deficiency reduced vascular inflammation and development of atherosclerosis in Western diet-induced apoE-deficient mice (2012)
  • Author(s): Usui F, Kimura H, Ohshiro T, Tatsumi K, Kawashima A, Nishiyama A, Iwakura Y, Ishibashi S, Takahashi M
  • Journal Title: Biochemical andBiophysical Research Communications Volume: 420 Pages: 72-77
  • Peer Reviewed
• [Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia reperfusion injury (2011)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U
  • Journal Title: Circulation Volume: 123 Pages: 594-604
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischemia (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U
  • Journal Title: Cardiovasc Res Volume: 90 Pages: 364-372
• [Journal Article] Inflammasome activation of cardiac fibroblasts is essential for myocardial ischemia reperfusion injury. (2011)
  • Author(s): Kawaguchi M, Takahashi M, Hata T, Kashima Y, Usui F, Morimoto H, Izawa A, Takahashi Y, Masumoto J, Koyama J, Hongo M, Noda T, Nakayama J, Sagara J, Taniguchi S, Ikeda U.
  • Journal Title: Circulation Volume: 123 Pages: 594-604
  • Peer Reviewed
• [Journal Article] Critical role of Th17 cells in inflammation and neovascularization after ischemia. (2011)
  • Author(s): Hata T, Takahashi M, Hida S, Kawaguchi M, Kashima Y, Usui F, Morimoto H, Nishiyama A, Izawa A, Koyama J, Iwakura Y, Taki S, Ikeda U.
  • Journal Title: Cardiovasc Res Volume: Jan11(in press)
  • Peer Reviewed
• [Presentation] 動脈硬化の形成におけるIL-17の役割 (2011)
  • Author(s): 臼井文武、木村博昭、岩倉洋一郎、高橋将文
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-09-23
• [Presentation] 動脈硬化形成におけるインフラマーソムの役割 (2011)
  • Author(s): 臼井文武、木村博昭、谷口俊一郎、高橋将文
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-09-23
• [Presentation] 動脈硬化形成におけるインフラマソームの役割 (2011)
  • Author(s): 臼井文武、木村博昭、谷口俊一郎、高橋将文
  • Organizer: 第32回日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-09-23
• [Presentation] 動脈硬化の形成におけるIL-17の役割 (2011)
  • Author(s): 臼井文武、木村博昭、岩倉洋一郎、高橋将文
  • Organizer: 第32回日本炎症・再生医学会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2011-06-03