Confirmed Bone Reconstruction treatment with Bone Formation Stimulatory Factor

• Project/Area Number: 22890184
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Showa University
• Principal Investigator: TACHI Keita 昭和大学, 歯学部, 助教 (90585671)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,977,000 (Direct Cost: ¥2,290,000、Indirect Cost: ¥687,000); Fiscal Year 2011: ¥1,417,000 (Direct Cost: ¥1,090,000、Indirect Cost: ¥327,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 再生医学 / BMP-2 / TGF-β / 骨芽細胞 / 軟骨細胞 / TGF-BETA1 / 骨再建 / 骨再生療法 / 破骨細胞 / 骨増生 / TGF-β1

Research Abstract

Bone morphogenetic protein(BMP)-induced ectopic bone formation. However, the detailed mechanisms of ectopic bone formation have not been fully understood. Since transforming growth factor(TGF)β is known to regulate bone metabolism, we examined the effects of TGFβ on bone morphogenetic protein(BMP)-induced ectopic bone formation using a mouse experimental model. The purpose of this research is to establish Bone Reconstruction treatment with BMP-2 and TGF-β.

Research Products

• [Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts (2012)
  • Author(s): Miyamoto A, Takami M, Matsumoto A, Mochizuki A, Yamada T, Tachi K, Shibuya I, Nakamachi T, Shioda S, Baba K, Inoue T, Miyamoto Y, Yim M, Kamijo R
  • Journal Title: Cytotechnology
  • Peer Reviewed
• [Journal Article] R848, a toll-like receptor 7 agonist, inhibits osteoclast differentiation but not survival or bone-resorbing function of mature osteoclasts (2011)
  • Author(s): Miyamoto A, et al
  • Journal Title: Cytotechnology Volume: (in press)
  • Peer Reviewed
• [Journal Article] Enhancement of bone morphogenetic protein-induced ectopic bone formation by transforming growth factor β. (2011)
  • Author(s): Tachi K, et al
  • Journal Title: Tissue Engineering Part A Volume: 17 Pages: 597-606
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein 2 enhances osteoclast differentiation via increased levels of receptor activator of NF-κB ligand expression in osteoblast (2010)
  • Author(s): Tachi K, Takami M, Zhao B, Mochizuki A, Yamada A, Miyamoto Y, Inoue T, Baba K, and Kamijo R
  • Journal Title: Cell Tissue Res Volume: 342(2) Pages: 213-20
  • Peer Reviewed
• [Journal Article] Enhancement of bone morphogenetic protein-induced ectopic bone formation by transforming growth factorβ (2010)
  • Author(s): Tachi K, Takami M, Sato H, Mochizuki A, Zhao B, Miyamoto Y, Tsukasaki H, Inoue T, Shintani S, Koike T, Honda Y, Suzuki O, Baba K, and Kamijo R
  • Journal Title: Tissue Eng Part A Volume: 17(5-6) Pages: 597-606
  • Peer Reviewed
• [Journal Article] Bone morphogenetic protein 2 enhances osteoclast differentiation via increased levels of receptor activator of NF-κB ligand expression in osteoblast. (2010)
  • Author(s): Tachi K, et al
  • Journal Title: Cell and Tissue Research Volume: 342 Pages: 213-20
  • Peer Reviewed
• [Presentation] TGF-BETA1はBMPの骨誘導活性を強力に促進する (2010)
  • Author(s): 舘慶太, 高見正道, 本田義知, 望月文子, 井上富雄, 鈴木治, 上條竜太郎, 馬場一美
  • Organizer: 第119回日本補綴歯科学会学術大会
  • Place of Presentation: 東京
• [Presentation] TGF-βは異所性骨形成を強力に促進する (2010)
  • Author(s): 舘慶太
  • Organizer: 第9回松本ボーンフォーラム
  • Place of Presentation: 長野
• [Presentation] TGF-β1はBMP-2による骨形成を強力に促進する (2010)
  • Author(s): 舘慶太, 高見正道, 佐藤華, 本田義知, 新谷悟, 鈴木治, 馬場一美, 上條竜太郎
  • Organizer: 第75回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 北九州
• [Presentation] TGF-β1はBMPの骨誘導活性を強力に促進する (2010)
  • Author(s): 舘慶太
  • Organizer: 第119回日本補綴歯科学会
  • Place of Presentation: 東京