| Project/Area Number |
22890241
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
|
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
SUENAGA Yusuke 千葉県がんセンター(研究所), がん治療開発グループ, 研究員 (80581793)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
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| Keywords | NCYM / MYCN / 神経芽腫 / Natural Antisense RNA / 遺伝子増幅 / GSK3β / p53ファミリー遺伝子 / GSK3 / p63 / P53ファミリー遺伝子 / P63 / 転写制御 |
|---|
| Research Abstract |
MYCN oncogene is frequently amplified in neuroblastoma, and MYCN contributes to aggressiveness of the tumors. NCYM is a cis-antisense transcript of MYCN gene and is co-amplified with MYCN gene in unfavorable neuroblastoma. However, the functional roles of NCYM in neuroblastoma remain elusive. In this study, we found that NCYM gene encodes nuclear protein, and the NCYM protein stabilizes MYCN to maintain the cellular survival of neurblastomas.
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