Molecular mechanism of differentiation of neural crest and neuroblastoma cells regulated by p53 family member
Project/Area Number |
22890242
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Pediatric surgery
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,068,000 (Direct Cost: ¥2,360,000、Indirect Cost: ¥708,000)
Fiscal Year 2011: ¥1,469,000 (Direct Cost: ¥1,130,000、Indirect Cost: ¥339,000)
Fiscal Year 2010: ¥1,599,000 (Direct Cost: ¥1,230,000、Indirect Cost: ¥369,000)
|
Keywords | 神経芽腫 / p53 / 発生分化 / p53ファミリー / がん幹細胞 / 神経幹細胞 |
Research Abstract |
Neuroblastoma is a pediatric tumor originated from the sympathetic nervous system and is thought to originate from a differentiation arrest of the neural crest. I have tried to establish the method to determine neural crest cells fate applied with in utero electroporation technique, but injection into neural tube was technically unfeasible to achieve, therefore I could not achieve to track neural crest cell differentiation status with reproducible results.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] TAp73 acts via the bHLH Hey2 to promote self-renewal of CNS neural stem cells2010
Author(s)
Fujitani M., DuganiCB, Weaver IC, Gauthier, FA, Paquin, A, WojtowiczM, TakMW, Miller, FD and KaplanDR
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Journal Title
Current Biology
Volume: 20(22)
Pages: 2058-65
Related Report
Peer Reviewed
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