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The association between ADH7 polymorphisms and alcohol consumption

Research Project

Project/Area Number 22890250
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Hygiene
Research InstitutionAichi Cancer Center Research Institute

Principal Investigator

OZE Isao  愛知県がんセンター(研究所), 疫学・予防部, 任意研修生 (00584509)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000)
Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000)
Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
Keywords疫学 / ゲノム
Research Abstract

ADH1B and ADH1C gene polymorphisms, rs1229984 and rs1693482 are associated with alcohol drinking habit and esophageal cancer risk, through modulating catalytic activity of ADH enzymes. However, there were few evidences about the association between other five ADHs and alcohol drinking. We investigated ADH gene polymorphisms and alcohol drinking habit of 4062 subjects. Rs1154460, the loci on ADH7 had significant association with alcohol drinking.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (5 results)

All 2012 2011 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Cigarette smoking and esophageal cancer risk : an evaluation based on a systematic review of epidemiologic evidence among the Japanese population2012

    • Author(s)
      Oze I, et al.
    • Journal Title

      Japanese journal of clinical oncology

      Volume: 42 Issue: 5 Pages: 63-73

    • DOI

      10.1093/jjco/hyr026

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Alcohol drinking and esophageal cancer risk : an evaluation based on a systematic review of epidemiologic evidence among the Japanese population2011

    • Author(s)
      Oze I, et al.
    • Journal Title

      Japanese journal of clinical oncology

      Volume: 41 Issue: 1 Pages: 677-92

    • DOI

      10.1093/jjco/hyr170

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population2010

    • Author(s)
      Oze Isao
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 1875-1880

    • NAID

      10027830779

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 飲酒行動に及ぼすアルコール脱水素酵素遺伝子多型の影響2012

    • Author(s)
      尾瀬功
    • Organizer
      第22回日本疫学会学術総会
    • Place of Presentation
      東京(学術総合センター)
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] ALDH2遺伝子多型と酒類別消費量の関連:J-MICC横断研究2011

    • Author(s)
      尾瀬功
    • Organizer
      第21回日本疫学会学術総会
    • Place of Presentation
      かでる2.7(北海道)
    • Year and Date
      2011-01-22
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-27   Modified: 2016-04-21  

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