The association between ADH7 polymorphisms and alcohol consumption

• Project/Area Number: 22890250
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Hygiene
• Research Institution: Aichi Cancer Center Research Institute
• Principal Investigator: OZE Isao 愛知県がんセンター(研究所), 疫学・予防部, 任意研修生 (00584509)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,146,000 (Direct Cost: ¥2,420,000、Indirect Cost: ¥726,000); Fiscal Year 2011: ¥1,508,000 (Direct Cost: ¥1,160,000、Indirect Cost: ¥348,000); Fiscal Year 2010: ¥1,638,000 (Direct Cost: ¥1,260,000、Indirect Cost: ¥378,000)
• Keywords: 疫学 / ゲノム

Research Abstract

ADH1B and ADH1C gene polymorphisms, rs1229984 and rs1693482 are associated with alcohol drinking habit and esophageal cancer risk, through modulating catalytic activity of ADH enzymes. However, there were few evidences about the association between other five ADHs and alcohol drinking. We investigated ADH gene polymorphisms and alcohol drinking habit of 4062 subjects. Rs1154460, the loci on ADH7 had significant association with alcohol drinking.

Research Products

• [Journal Article] Cigarette smoking and esophageal cancer risk : an evaluation based on a systematic review of epidemiologic evidence among the Japanese population (2012)
  • Author(s): Oze I, et al.
  • Journal Title: Japanese journal of clinical oncology Volume: 42 Issue: 5 Pages: 63-73
  • DOI: 10.1093/jjco/hyr026
  • Peer Reviewed
• [Journal Article] Alcohol drinking and esophageal cancer risk : an evaluation based on a systematic review of epidemiologic evidence among the Japanese population (2011)
  • Author(s): Oze I, et al.
  • Journal Title: Japanese journal of clinical oncology Volume: 41 Issue: 1 Pages: 677-92
  • DOI: 10.1093/jjco/hyr170
  • Peer Reviewed
• [Journal Article] Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population (2010)
  • Author(s): Oze Isao
  • Journal Title: Cancer Science Volume: 101 Pages: 1875-1880
  • NAID: 10027830779
  • Peer Reviewed
• [Presentation] 飲酒行動に及ぼすアルコール脱水素酵素遺伝子多型の影響 (2012)
  • Author(s): 尾瀬功
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京(学術総合センター)
  • Year and Date: 2012-01-26
• [Presentation] ALDH2遺伝子多型と酒類別消費量の関連:J-MICC横断研究 (2011)
  • Author(s): 尾瀬功
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: かでる2.7(北海道)
  • Year and Date: 2011-01-22