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Construction of metal complex assemblies using DNA-template and the application for functional films

Research Project

Project/Area Number 22K14695
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 34010:Inorganic/coordination chemistry-related
Research InstitutionJosai University

Principal Investigator

Nakaya Manabu  城西大学, 理学部, 助教 (10822554)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords金属錯体 / DNA / 自己集合 / ナノ材料 / 分子集積 / 磁気特性
Outline of Research at the Start

本研究では、ナノ構造材料の作成にも利用されているDNAを鋳型として利用し、対となる核酸塩基を有する金属錯体との選択的な分子認識を駆動力とした錯体分子集積化法の確立を目指す。また、磁性金属錯体-DNA複合体に脂質を含ませることで機能性複合フィルムの作成を行い、錯体分子の数・方向・分子間距離の磁気特性への影響を明らかにする。

Outline of Final Research Achievements

In this study, we synthesized salen-type platinum(II) and zinc(II) complexes with thymine(T) substituent, and hybridized them with adenine(A) oligomers.
We successfully arranged the complex molecules by A-T interaction. Oligomers consisting of five adenine molecules (A-5mer) had low structural stability and could not be formed the interactions.
On the other hand, A-10mer and A-15mer showed absorption spectral changes depending on the number of complex molecules, suggesting that they were quantitatively aligned through A-T interactions. In other words, the nucleobase incorporation succeeded in the accumulation of metal complex molecules with a precisely controlled number of molecules. In the future, we will produce the thin films by compositing of the metal complex-DNA assembly with lipids.

Academic Significance and Societal Importance of the Research Achievements

従来、分子性金属錯体の集積化は有機溶媒や錯体濃度、その他様々な条件に起因するため次元性・配向性の制御が困難であった。本手法は、核酸塩基の導入のみが分子集積制御の鍵となっており金属錯体種に寄らないことから、あらゆる錯体分子に対応した新しい錯体分子集積化法を確立することができる。また、鋳型となるDNA鎖は塩基配列を自在に組み替えることができ、複数の金属錯体に異なる核酸塩基を導入することで異種錯体の混合配列も可能となる。すなわち、異なる機能を持つ金属錯体の複合化による多機能性材料の開発も可能となり、新たな機能性ナノ物質化学を開拓することができる。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (17 results)

All 2024 2023 2022 2021

All Journal Article (8 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] pH-driven optical changes of platinum(ii) complexes having carboxy-appended salophen ligands2023

    • Author(s)
      Fujii Shun、Yagi Hajime、Kawaguchi Tomohiro、Ishikawa Mitsuru、Izumiyama Naoki、Nakaya Manabu
    • Journal Title

      Dalton Transactions

      Volume: 52 Issue: 29 Pages: 10206-10212

    • DOI

      10.1039/d3dt00956d

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Janus-Type Mixed-Valent Copper-Cyanido Honeycomb Layers2023

    • Author(s)
      Yuudai Iwai, Yuki Imamura, Manabu Nakaya, Miki Inada, Benjamin Le Ouay, Masaaki Ohba, Ryo Ohtani
    • Journal Title

      Inorganic Chemistry

      Volume: 62 Issue: 45 Pages: 18707-18713

    • DOI

      10.1021/acs.inorgchem.3c03100

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Cooperative Spin-State Switching and Vapochromism of Mononuclear Ni(II) Complexes by Pyridine Coordination/Decoordination2023

    • Author(s)
      Kusumoto Sotaro、Inaba Kazumasa、Suda Harutoshi、Nakaya Manabu、Tokunaga Ryuya、Thu?ry Pierre、Haruki Rie、Kanazawa Tomoki、Nozawa Shunsuke、Kim Yang、Hayami Shinya、Koide Yoshihiro
    • Journal Title

      Inorganic Chemistry

      Volume: 62 Issue: 39 Pages: 16222-16227

    • DOI

      10.1021/acs.inorgchem.3c02776

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal Design for Tuning the Mechanical Flexibilities of M(salophen) Complexes2023

    • Author(s)
      Sekine Yoshihiro、Kusumoto Sotaro、Sugimoto Akira、Nakaya Manabu、Hayami Shinya
    • Journal Title

      Crystal Growth & Design

      Volume: 23 Issue: 4 Pages: 2013-2017

    • DOI

      10.1021/acs.cgd.2c01398

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multi-faceted elastic flexibility of 1-naphthyl and 9-anthryl 2,2′:6′,2′′-terpyridine crystals2022

    • Author(s)
      Kusumoto Sotaro、Oishi Karin、Nakaya Manabu、Suzuki Ryo、Tachibana Masaru、Kim Yang、Koide Yoshihiro、Hayami Shinya
    • Journal Title

      CrystEngComm

      Volume: 24 Issue: 47 Pages: 8303-8308

    • DOI

      10.1039/d2ce01167k

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Zero area thermal expansion of honeycomb layers via double distortion relaxation in (PPh4)[Cu2(CN)3]2022

    • Author(s)
      Iwai Yuudai、Nakaya Manabu、Ohtsu Hiroyoshi、Le Ouay Benjamin、Ohtani Ryo、Ohba Masaaki
    • Journal Title

      CrystEngComm

      Volume: 24 Issue: 33 Pages: 5880-5884

    • DOI

      10.1039/d2ce00878e

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Modulation of the elasticity of single crystal, 1-D metal dimethylglyoximato complexes <i>via</i> solid solution effect2022

    • Author(s)
      Sugimoto Akira、Kusumoto Sotaro、Nakaya Manabu、Sekine Yoshihiro、Lindoy Leonard F.、Hayami Shinya
    • Journal Title

      CrystEngComm

      Volume: 24 Issue: 26 Pages: 4656-4660

    • DOI

      10.1039/d2ce00402j

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Ferroelectric Metallomesogen Exhibiting Field‐Induced Slow Magnetic Relaxation2021

    • Author(s)
      Akiyoshi Ryohei、Zenno Hikaru、Sekine Yoshihiro、Nakaya Manabu、Akita Motoko、Kosumi Daisuke、Lindoy Leonard F.、Hayami Shinya
    • Journal Title

      Chemistry - A European Journal

      Volume: 28 Issue: 5

    • DOI

      10.1002/chem.202103367

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] アデニンオリゴマーを鋳型とした選択的水素結合による白金(II)錯 体の集積制御2024

    • Author(s)
      藤井 駿、仲谷 学
    • Organizer
      日本化学会 第104春季年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 嵩高い置換基を有する発光性コバルト(II)錯体の固体および溶液中でのスピン状態変化2024

    • Author(s)
      仲谷 学、泉山 直輝
    • Organizer
      日本化学会 第104春季年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] CO2-induced spin state switching of a porous molecular crystalline cobalt(II) complex2023

    • Author(s)
      Manabu Nakaya
    • Organizer
      1st International Conference on Spin Transition
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Acid- and base-induced reversible luminescence change of carboxy-appended platinum(II) complexes2023

    • Author(s)
      Manabu Nakaya, Shun Fujii
    • Organizer
      錯体化学会 第73回討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 核酸塩基を導入したシッフ塩基錯体の合成と光学特性評価2023

    • Author(s)
      藤井駿、仲谷学
    • Organizer
      錯体化学会 第73回討論会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 酸・塩基応答を示す発光性白金(II)錯体の合成2023

    • Author(s)
      藤井駿、仲谷学
    • Organizer
      錯体化学若手の会 夏の学校2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 水素結合型白金二価錯体の合成と発光特性2022

    • Author(s)
      藤井駿,仲谷学
    • Organizer
      錯体化学会第72回討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] 動的な置換基を有するコバルト二価錯体の合成と磁気特性評価2022

    • Author(s)
      泉山直輝,仲谷学
    • Organizer
      錯体化学会第72回討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] カルボン酸置換基を導入したサロフェン型Pt(II)錯体のpH応答性による発光特性の評価2022

    • Author(s)
      藤井駿,仲谷学,泉山直輝
    • Organizer
      錯体化学若手の会 夏の学校2022
    • Related Report
      2022 Research-status Report

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Published: 2022-04-19   Modified: 2025-01-30  

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