• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of the molecular mechanisms of metastasis and tumor immune evasion in hepatocellular carcinoma

Research Project

Project/Area Number 22K15544
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 50010:Tumor biology-related
Research InstitutionKyushu University

Principal Investigator

TOMINO Takahiro  九州大学, 医学研究院, 共同研究員 (10906340)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2023: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsVETC / mTOR / Ang-2 / 肝細胞癌
Outline of Research at the Start

肝細胞癌の転移や腫瘍免疫回避にAng2、VEGF、Rac、DOCK1が関与する可能性はあるが、その詳細は未だ不明な部分が多く、その解明は急務であると思われる。本研究では、肝細胞癌における転移の分子機構および腫瘍免疫回避機構を解明し、その中心的役割を担う遺伝子を制御する薬剤を開発して免疫チェックポイント阻害剤の奏功率を向上させることを目的とする。

Outline of Final Research Achievements

This study aimed to elucidate the molecular mechanisms of metastasis and tumor immune evasion in hepatocellular carcinoma (HCC). Cases of HCC patients who underwent hepatectomy or living donor liver transplantation at our institution were evaluated for the expression of VETC, Ang-2, and mTOR by immunohistochemical staining. Among the patients, those who were VETC-positive showed a significantly higher rate of mTOR positivity compared to VETC-negative patients, and the expression of Ang-2 was significantly higher in the mTOR-positive group than in the mTOR-negative group. Among cases of HCC recurrence after living donor liver transplantation, the expression of mTOR was significantly higher in recurrent lesions that were positive for VETC compared to those that were negative for VETC. Additionally, mTOR expression was found to be higher in primary and recurrent lesions that were VETC-positive compared to those that were VETC-negative.

Academic Significance and Societal Importance of the Research Achievements

本研究により肝細胞癌に対して生体肝移植術を施行した患者においてmTOR発現は、VETC陰性の原発巣および再発病変よりもVETC陽性の原発巣および再発病巣で高いことが明らかとなった。生体肝移植後のエベロリムスの使用がVETC陽性の肝細胞癌患者における腫瘍再発を予防または減少させる可能性があることが示唆され、生体肝移植術を施行した肝細胞癌患者の治療に重要な意味を持つ。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (1 results)

All 2023

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Clinical significance of mechanistic target of rapamycin expression in vessels that encapsulate tumor cluster‐positive hepatocellular carcinoma patients who have undergone living donor liver transplantation2023

    • Author(s)
      Toshida Katsuya、Itoh Shinji、Toshima Takeo、Yoshiya Shohei、Goto Ryoichi、Mita Atsuyoshi、Harada Noboru、Kohashi Kenichi、Oda Yoshinao、Yoshizumi Tomoharu
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 8 Issue: 1 Pages: 163-171

    • DOI

      10.1002/ags3.12735

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2022-04-19   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi