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Development of Real-time AI for Predicting Lesion Formation and Steam-pop during High-frequency Ablation

Research Project

Project/Area Number 22K16068
Research Category

Grant-in-Aid for Early-Career Scientists

Allocation TypeMulti-year Fund
Review Section Basic Section 53020:Cardiology-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Masateru Takigawa  東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座講師 (40760062)

Project Period (FY) 2022-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2023: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2022: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords不整脈 / catheter ablation / radiofrequency / 焼灼巣 / 機械学習 / 高周波 / アブレーション / AI / Steam-pop / 温度コントロール / イリゲーションカテーテル / 焼灼効果 / steam-pop / カテーテルアブレーション / 人工知能 / 合併症 / 抵抗値
Outline of Research at the Start

高周波カテーテルアブレーション(RFCA)をを効果的に安全に行う指標として、出力・焼灼時間・コンタクトフォース等の能動的指標が用いられてきたが、これらの指標は、焼灼時の組織反応を反映していない為、安全性を測る指標としては限界がある。そこで,近年、焼灼部の局所温度や局所抵抗値といった受動的指標を直接測定できるカテーテルが開発された。本研究では、これらの能動的・受動的指標の変動を経時的に測定して、焼灼巣のサイズや、Steam-popといった合併症を予測するリアルタイムAIアルゴリズムを開発する。動物実験でAIの予測性能を評価し、最終的に臨床現場で使用可能な、AIを搭載したカテーテルの開発に繋げる。

Outline of Final Research Achievements

RF applications were performed in ex-vivo environment with several configurations. Machine learning was performed using the data showing the relation between active indices, passive indices, and detailed lesion metrics, in order to create the model predicting the lesion characteristics and steam-pops. Patent was applied with this development (TOKUGAN2023-119252;TOKUGAN2023-110489). This model showed significantly more accurate predictive accuracy. Since the first model was developed based on the ex-vivo model, we are now working to develop the novel model based on the in-vivo data. During this project, several abstracts were presented in a scientific session, and the several manuscript was published.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果、通電中に変動するパラメータより自動的に、焼灼巣の形状が予測されることにより、より効率的で安全な高周波アブレーション治療が可能になる可能性がある。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (11 results)

All 2024 2023

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 3 results) Presentation (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Impact of contact force on the lesion characteristics of very high‐power short‐duration ablation using a <scp>QDOT‐MICRO</scp> catheter2024

    • Author(s)
      Yamaguchi Junji、Takigawa Masateru、Goya Masahiko、Martin Claire A.、Negishi Miho、Yamamoto Tasuku、Ikenouchi Takashi、Goto Kentaro、Shigeta Takatoshi、Kawamura Iwanari、Nishimura Takuro、Takamiya Tomomasa、Tao Susumu、Miyazaki Shinsuke、Sasano Tetsuo
    • Journal Title

      Journal of Arrhythmia

      Volume: 40 Issue: 2 Pages: 247-255

    • DOI

      10.1002/joa3.12992

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An optimized approach for increasing lesion size in temperature‐controled setting using a catheter with a surface thermocouple and efficient irrigation2024

    • Author(s)
      Takigawa Masateru、Yamaguchi Junji、Goya Masahiko、Iwakawa Hidehiro、Yamamoto Tasuku、Amemiya Miki、Ikenouchi Takashi、Negishi Miho、Kawamura Iwanari、Goto Kentaro、Shigeta Takatoshi、Nishimura Takuro、Takamiya Tomomasa、Tao Susumu、Ohuchi Katsuhiro、Suzuki Sayaka、Miyazaki Shinsuke、Sasano Tetsuo
    • Journal Title

      Journal of Arrhythmia

      Volume: 00 Issue: 3 Pages: 1-16

    • DOI

      10.1002/joa3.13040

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Superiority of the Combination of Input and Output Parameters to the Single Parameter for Lesion Size Estimation2023

    • Author(s)
      Superiority of the Combination of Input and Output Parameters to the Single Parameter for Lesion Size Estimation.
    • Journal Title

      Circulation Journal

      Volume: 87 Issue: 12 Pages: 1757-1764

    • DOI

      10.1253/circj.CJ-23-0574

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2023-11-24
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ikenouchi T, Takigawa M, Goya M, Yamaguchi J, Martin CA, Yamamoto T, Negishi M, Kawamura I, Goto K, Shigeta T, Nishimura T, Takamiya T, Tao S, Miyazaki S, Sasano T2023

    • Author(s)
      The effect of half-normal saline irrigation on lesion characteristics in temperature-flow-controlled ablation.
    • Journal Title

      Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

      Volume: 0 Issue: 6 Pages: 0-0

    • DOI

      10.1007/s10840-023-01678-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Yamaguchi J, Takigawa M, Goya M, Yamamoto T, Ikenouchi T, Iwakawa H, Negishi M, Goto K, Shigeta T, Nishimura T, Takamiya T, Tao S, Miyazaki S, Sasano T2023

    • Author(s)
      Safety verification of a novel irrigation catheter with flexible tip of laser-cut kerfs and contact force sensor.
    • Journal Title

      Pacing and clinical electrophysiology : PACE

      Volume: 46 Issue: 12 Pages: 0-0

    • DOI

      10.1111/pace.14868

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Takigawa M, Yamamoto T, Amemiya M, Martin CA, Ikenouchi T, Yamaguchi J, Negishi M, Goto K, Shigeta T, Nishimura T, Tao S, Miyazaki S, Goya M, Sasano T2023

    • Author(s)
      Impact of baseline pool impedance on lesion metrics and steam pops in catheter ablation.
    • Journal Title

      Journal of cardiovascular electrophysiology

      Volume: 34 Issue: 8 Pages: 0-0

    • DOI

      10.1111/jce.15964

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of lesion characteristics using temperature‐flow‐controlled versus conventional power‐controlled ablation with fixed ablation index2023

    • Author(s)
      Ikenouchi Takashi、Takigawa Masateru、Goya Masahiko、Martin Claire A.、Yamamoto Tasuku、Yamaguchi Junji、Goto Kentaro、Shigeta Takatoshi、Nishimura Takuro、Tao Susumu、Miyazaki Shinsuke、Sasano Tetsuo、and other members of the Study Group
    • Journal Title

      Journal of Cardiovascular Electrophysiology

      Volume: 34 Issue: 4 Pages: 908-917

    • DOI

      10.1111/jce.15883

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of three different approaches to very high‐power short‐duration ablation using the QDOT‐MICRO catheter2023

    • Author(s)
      Yamaguchi Junji、Takigawa Masateru、Goya Masahiko、Martin Claire A.、Yamamoto Tasuku、Ikenouchi Takashi、Shigeta Takatoshi、Nishimura Takuro、Tao Susumu、Miyazaki Shinsuke、Sasano Tetsuo
    • Journal Title

      Journal of Cardiovascular Electrophysiology

      Volume: 34 Issue: 4 Pages: 888-897

    • DOI

      10.1111/jce.15875

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Presentation] Impact of machine-learning model on the prediction of lesion metrics in radiofrequency ablation2023

    • Author(s)
      Takigawa Masateru
    • Organizer
      日本心電図不整脈学会
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] 焼灼巣の大きさを示すデータを出力するためのプログラム2023

    • Inventor(s)
      川 正晃 藤原 幸一 角田 柊二
    • Industrial Property Rights Holder
      川 正晃 藤原 幸一 角田 柊二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-110489
    • Filing Date
      2023
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] スチームポップの発生を予測するためのプログラム2023

    • Inventor(s)
      川 正晃 藤原 幸一 角田 柊二
    • Industrial Property Rights Holder
      川 正晃 藤原 幸一 角田 柊二
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2023-119252
    • Filing Date
      2023
    • Related Report
      2023 Annual Research Report

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Published: 2022-04-19   Modified: 2025-01-30  

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