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Development of new behavioral systems for investigating the mechanism of pleasure in food eating

Research Project

Project/Area Number 22K19749
Research Category

Grant-in-Aid for Challenging Research (Exploratory)

Allocation TypeMulti-year Fund
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionNagoya University

Principal Investigator

Mizoguchi Hiroyuki  名古屋大学, 医学部附属病院, 准教授 (70402568)

Project Period (FY) 2022-06-30 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2023: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords食行動 / 喜び / 神経回路
Outline of Research at the Start

「食べる・食事」は生きていくための営みであり、さらに食事を通して他者と時間を過ごすことで人間関係を構築するための手段(会話の助け)としても利用されてきた。しかし、小食という現代社会を生きる私たちは、食がもたらす喜びや育みをさほど考慮しない状況で営んでいる。それゆえ、食行動の意味合いに焦点を当て、食がもたらす喜びはどのように生まれ、食の選択や食を求める行動(食行動)が導かれるのか、食行動の理解を進め、経験と良識を増やすことで食のウェルネス(生きる力)を追及することが重要である。本研究では、食報酬に対する快・喜びと食行動を評価する新規システムの確立と喜びや食行動に関わる脳内神経回路の解明を目指す。

Outline of Final Research Achievements

In this study, we aimed to establish a new system for evaluating pleasure in response to food rewards and eating behavior, and to investigate the neural circuits in the brain related to pleasure and eating behavior. We were able to extract the ultrasonic vocalizations made when receiving rewards using ultrasonic vocalization device. We also confirmed that neural activity in the brain can be measured using biosensors. Unfortunately, we have not yet established a stable method for facial expression analysis, so we will proceed with the preparation of a head-fixed eating behavior measurement device. Furthermore, we found that the orexin release changes significantly during reward acquisition. Since some reactions were observed even in control animals, it will be necessary to investigate the cause.

Academic Significance and Societal Importance of the Research Achievements

2年という研究期間において、報酬獲得時の超音波発声を抽出することができた。また、バイオセンサーにより、報酬獲得時の神経伝達物質やペプチド遊離反応をリアルタイムに測定できることに成功し、超音波測定と脳内神経活動との同期に成功した。残念ながら、表情解析との同期までは至っていないが、少なくとも、食がもたらす喜びや行動を評価することが可能であり、リアルタイムな変化を抽出することに成功したことは、学術的意義が大きい。

Report

(3 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • Research Products

    (14 results)

All 2024 2023 2022

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (10 results)

  • [Journal Article] Retrospective Analysis of Neutrophil-to-Lymphocyte Ratio in Patients with Melanoma Who Received Ipilimumab Monotherapy or Ipilimumab in Combination with Nivolumab in Japan2023

    • Author(s)
      Matsumura Yuka、Kawarada Yuki、Matsuo Momo、Yokota Kenji、Mizoguchi Hiroyuki、Akiyama Masashi、Yamada Kiyofumi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 3 Pages: 427-431

    • DOI

      10.1248/bpb.b22-00750

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-03-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia2023

    • Author(s)
      Liao Jingzhu、Dong Geyao、Zhu Wenjun、Wulaer Bolati、Mizoguchi Hiroyuki、Sawahata Masahito、Liu Yue、Kaibuchi Kozo、Ozaki Norio、Nabeshima Toshitaka、Nagai Taku、Yamada Kiyofumi
    • Journal Title

      Pharmacological Research

      Volume: 194 Pages: 106838-106838

    • DOI

      10.1016/j.phrs.2023.106838

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene.2023

    • Author(s)
      Tanaka R, Liao J, Hada K, Mori D, Nagai T, Matsuzaki T, Nabeshima T, Kaibuchi K, Ozaki N, Mizoguchi H, Yamada K.
    • Journal Title

      Pharmacological Research

      Volume: 187 Pages: 106589-106589

    • DOI

      10.1016/j.phrs.2022.106589

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antipsychotic-like effects of fasudil, a Rho-kinase inhibitor, in a pharmacologic animal model of schizophrenia.2022

    • Author(s)
      Takase S, Liao J, Liu Y, Tanaka R, Miyagawa Y, Sawahata M, Sobue A, Mizoguchi H, Nagai T, Kaibuchi K, Ozaki N, Yamada K.
    • Journal Title

      European Journal of Pharmacology

      Volume: 15;931 Pages: 175207-175207

    • DOI

      10.1016/j.ejphar.2022.175207

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Orexin neurons mediates motivation under reward-based motivative behavior2024

    • Author(s)
      Yutao Dong, Hiroyuki Mizoguchi, Akihiro Yamanaka, Kiyofumi Yamada
    • Organizer
      第144回日本薬理学会近畿部会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Abnormal behavior and glial responses in an animal model of tau pathology2023

    • Author(s)
      Yue Liu, Hiroyuki Mizoguchi1,Akira Sobue, Naruhiko Shara, Koji Yamanaka, Kiyofumi Yamada
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Rho-kinase 2選択的阻害剤は日本人統合失調症患者で見つかったArhgap10 遺伝子バリアントを有するマウスの内側前頭前皮質のスパイン密度低下を改善する2023

    • Author(s)
      田中里奈子、朱 文俊、森 大輔、毛利彰宏、永井 拓、鍋島俊隆、貝淵弘三、橘 大輝、小林洋平、尾崎紀夫、溝口博之、山田清文
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Phosphoproteomic Insights into Methamphetamine-Induced Cognitive Dysfunction2023

    • Author(s)
      Wenjun Zhu, Jingzhu Liao, Geyao Dong, Rinako Tanaka, Tetsuo Matsuzaki, Hiroyuki Mizoguchi, Kozo Kaibuchi, Norio Ozaki, Toshitaka Nabeshima, Taku Nagai and Kiyofumi Yamada
    • Organizer
      2023年度アルコール・薬物依存関連学会合同学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Selective rho-associated protein kinase inhibitor has the potential to be a novel therapeutic target for schizophrenia2023

    • Author(s)
      Wenjun Zhu, Rinako Tanaka, Jingzhu Liao, Daisuke Mori, Akihiro Mouri, Hiroyuki Mizoguchi, Taku Nagai, Toshitaka Nabeshima, Kozo Kaibuchi, Yohei Kobayashi, Norio Ozaki, Kiyofumi Yamada
    • Organizer
      第53回日本神経精神薬理学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Reln-del Mice Exhibit Defects in Neural Circuitry and Social Communication2023

    • Author(s)
      Youyun Zhu, Yumi Tsuneura, Hiroyuki Mizoguchi, Masahito Sawahata, Daisuke Mori, Takao Kohno, Mitsuharu Hattori, Toshitaka Nabeshima, Norio Ozaki, Kiyofumi Yamada
    • Organizer
      第143回日本薬理学会近畿部会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Changes in expression of interferon-induced transmembrane protein-3 (IFITM3) in the brain of animal model mice of Alzheimer's diseas.2022

    • Author(s)
      Yue Liu, Hiroyuki Mizoguchi, Akira Sobue, Koji Yamanaka, Kiyofumi Yamada.
    • Organizer
      第96回日本薬理学会年会・第43回日本臨床薬理学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 意欲、衝動とオレキシン神経2022

    • Author(s)
      溝口博之、山中章弘、山田清文
    • Organizer
      BPCNPNPPP 4学会合同年会
    • Related Report
      2022 Research-status Report
  • [Presentation] 依存症の発症機序と精神薬理2022

    • Author(s)
      溝口博之
    • Organizer
      BPCNPNPPP 4学会合同年会
    • Related Report
      2022 Research-status Report
  • [Presentation] Functional roles of orexin neurons in reward-based motivative behavior in rats.2022

    • Author(s)
      Hiroyuki Mizoguchi, Yutao Dong, Akihiro Yamanaka, Kiyofumi Yamada.
    • Organizer
      Neuro2022
    • Related Report
      2022 Research-status Report

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Published: 2022-07-05   Modified: 2025-01-30  

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