Structure and function of an improving factor in hippocampal impairment originated from the silkworm-parasitic fungus (Paecilomyces tenuipes) and practical use for human brain

• Project/Area Number: 23228001
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Applied entomology
• Research Institution: Iwate University
• Principal Investigator: Suzuki Koichi 岩手大学, その他部局, 特任教授 (20003791)
• Co-Investigator(Kenkyū-buntansha): GORYO Masanobu 岩手大学, 農学部, 教授 (80153774) ; SHINADA Tetsuro 大阪市立大学, 理学研究科, 教授 (30271513) ; TERAYAMA Yasuo 岩手医科大学, 医学部, 教授 (70146596) ; YOSHIOKA Yoshichika 大阪大学, 学内共同利用施設等, 教授 (00174897) ; 高橋 智 岩手医科大学, 医学部, 教授 (50216719)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥206,830,000 (Direct Cost: ¥159,100,000、Indirect Cost: ¥47,730,000); Fiscal Year 2015: ¥33,410,000 (Direct Cost: ¥25,700,000、Indirect Cost: ¥7,710,000); Fiscal Year 2014: ¥40,040,000 (Direct Cost: ¥30,800,000、Indirect Cost: ¥9,240,000); Fiscal Year 2013: ¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000); Fiscal Year 2012: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000); Fiscal Year 2011: ¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
• Keywords: 昆虫利用 / 機能開発 / 有用物質生産 / 養蚕イノベーション / 病理解剖 / 生物有機化学 / 脳神経 / 脳神経疾患 / 生物有機科学 / 昆虫バイオテクノロジー / 昆虫機能利用 / 養蚕 / 生理活性

Outline of Final Research Achievements

A novel and biologically active molecule originated from the extract of entomopathogenic fungus (Paecilomyces tenuipes = Isaria japonica) was identified as a promising factor which is reponsible for improving astrogliosis in the CA3 are of hippocampus of aged mice.
This finding led us to the understanding of molecular mechanism: we found that the agent enhances astrocyte proliferation and significantly activates astrocyte-derived NGF and VGF genes, and in primary cultured neurons it accelerates the neurocyte dendrite formation. The in vitro multipotency stimulated us to evaluate the effects of oral administration of the agent on brain improvement in senscense-acclerated mice and preclinical trials with the oral administration of I. japonica powder for Alzheimer's dementia (AD). These results suggest that the agent and I. japonica powder are a promising astrocyte-targeting drug and new functional food for treating AD.

Assessment Rating

Verification Result (Rating)

A-

Research Products

• [Journal Article] 昆虫資源による医療分野への挑戦（No.2）－健康寿命延長剤を目指す (2016)
  • Author(s): 鈴木幸一
  • Journal Title: 昆虫と自然 Volume: 51（1） Pages: 32-35
  • NAID: 40020744802
  • Acknowledgement Compliant
• [Journal Article] 昆虫資源による医療分野への挑戦（No.3）－食べる化粧剤を目指す (2016)
  • Author(s): 鈴木幸一
  • Journal Title: 昆虫と自然 Volume: 51（2） Pages: 38-41
  • Acknowledgement Compliant
• [Journal Article] 昆虫資源による医療分野への挑戦（No.4）－NK細胞活性剤を目指す (2016)
  • Author(s): 鈴木幸一
  • Journal Title: 昆虫と自然 Volume: 51（3） Pages: 42-45
  • Acknowledgement Compliant
• [Journal Article] Structure etermination of monomeric phloroglucinol derivatives with a cinnamoyl group isolated from propolis of the stingless bee, Tetragonula carbonaria (2016)
  • Author(s): Nishimura, E, Murakami, S., Suzuki, K., Amano, K., Tanaka, R., Shinada, T.
  • Journal Title: Asian Journal of Organic Chemistry Volume: in press Issue: 7 Pages: 855-859
  • DOI: 10.1002/ajoc.201600106
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of Asiasarum Root Extract and Its Constituents on Interleukin-1β-Stimulated Matrix Metalloproteinase-1 Secretion from Human Gingival Fibroblasts (2016)
  • Author(s): Futamura-Masuda, M., Yokota-Honda, M., Anraku, T., Nakanishi, K., Murata, K., Shinada, T., Matsuda, H.
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 5 Pages: 823-831
  • DOI: 10.1248/bpb.b15-01000
  • NAID: 130005149263
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Spectroscopic investigation of the carotenoid deoxyperidinin: direct observation of the forbidden S0 → S1 transition (2016)
  • Author(s): Greco, J. A., LaFountain, A. M., Kinashi, N., Shinada, T., Sakaguchi, K., Katsumura, S., S., Magdaong, S., Niedzwiedzki, D.M.R., Birge, R.H., Frank, A.
  • Journal Title: The Journal of Physiological Chemistry B Volume: 120 Issue: 10 Pages: 2731-2734
  • DOI: 10.1021/acs.jpcb.6b00439
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Oosorption in a stink bug, Plautia stali: role of juvenile hormone in the induction of oosorption (2016)
  • Author(s): Kotaki, T., Kaihara, K., Ando, Y., Misaki, K., Shinada, T.
  • Journal Title: Physiological Entomology Volume: 41 Issue: 2 Pages: 127-131
  • DOI: 10.1111/phen.12136
  • Peer Reviewed
• [Journal Article] The stereoselective construction of E- and Z-Δ-Ile from E-dehydroamino acid ester: the synthesis of the phomopsin A tripeptide side chain (2016)
  • Author(s): Y. Yasuno, A. Nishimura, Y. Yasukawa, Y. Karita, Y. Ohfune, T. Shinada
  • Journal Title: Chem. Commun Volume: 52 Issue: 7 Pages: 1478-1481
  • DOI: 10.1039/c5cc08458j
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] (7S)-Kaitocephalin as a potent NMDA receptor selective ligand (2016)
  • Author(s): Y. Yasuno, M. Hamada, M. Kawasaki, K. Shimamoto, Y. Shigeri, T. Akizawa, M. Konishi, Y. Ohfune, T. Shinada
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  • DOI: 10.1039/c5ob02301g
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• [Journal Article] Preparation of E-α-stannyl-β-trimethylsilylethynylacrylate, building block for polyconjugated ylidenebutenolide and its derivatives, by novel E-selective ethynylstannylation of propiolate (2016)
  • Author(s): Kinashi, N., Sakaguchi, K., Katsumura, S., Shinada, T.
  • Journal Title: Tetrahedron Letters Volume: 57 Issue: 1 Pages: 129-132
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• [Journal Article] カイコ冬虫夏草の乾燥粉末のアルツハイマー型認知症脳機能向上に及ぼす効果 (2016)
  • Author(s): 寺山靖夫・大塚千久美・鈴木幸一
  • Journal Title: 岩手医学雑誌 Volume: in press
  • NAID: 40021050856
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• [Journal Article] Randomized double-blind placebo-controlled multicenter trial of Yokukansan for neuropsychiatric symptoms in Alzheimer's disease. (2016)
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  • Author(s): Yoshimasa Makita, Masashi Inoue, Natsuki Katayama, Hsien-Han Lee, Taro Abe, Chizuko Inui-Yamamoto, Yuki Mori, Yoshichika Yoshioka, Yoshitomo Honda, Shoko Gamoh, Kimishige Shimizutani, Shin-ichi Fujiwara, Akiya Ogawa
  • Journal Title: Polyhedron Volume: 107 Pages: 148-152
  • DOI: 10.1016/j.poly.2015.12.064
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• [Journal Article] SPIOを用いたループス腎炎の評価 (2016)
  • Author(s): 陳挺・森勇樹・程振宇・Lee, S., Barry, R.・ 岸本忠三・乾千珠子・多胡善幸・ 吉田慎一・大野工司・吉岡芳親.
  • Journal Title: 日本磁気共鳴医学会雑誌 Volume: 36 Pages: 55-58
• [Journal Article] Acute and sub-chronic toxicity analyses of hot-water extract of Isaria japonica from sil kworm (Bombyx mori) puape (2015)
  • Author(s): Sillapakong, P., Goryo, M., Sasaki, J., Oda, S., Hirag,a T., Uchiyama, S., Nishimura, E., Shinada, T., Ohtsuka, C., Terayama, Y., Suzuki, K.
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• [Journal Article] Male reproductive maturity and diapause termination in the leaf beetle Gastrophysa atrocyanea (2015)
  • Author(s): Ojima, N., Ishiguro, S., An, Y., Kadosawa, T., Suzuki, K.
  • Journal Title: Physiological Entomology Volume: 40 Issue: 4 Pages: 277-283
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  • Journal Title: PLOS ONE Volume: 10 Issue: 11 Pages: e0142917-e0142917
  • DOI: 10.1371/journal.pone.0142917
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  • NAID: 130004888048
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  • Author(s): 吉野瑞希・平島一輝・佐々木 淳・倉持 好・御領政信
  • Journal Title: 鶏病研究会報 Volume: 51 Pages: 22-32
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• [Journal Article] コガタルリハムシの成虫休眠機構 (2015)
  • Author(s): 石黒慎一・小島信幸・鈴木幸一
  • Journal Title: 蚕糸・昆虫バイオテック Volume: 84 Pages: 145-154
  • NAID: 130006162017
  • Acknowledgement Compliant
• [Journal Article] 昆虫資源による医療分野への挑戦（No.1）－認知症薬を目指す (2015)
  • Author(s): 鈴木幸一
  • Journal Title: 昆虫と自然 Volume: 50（13） Pages: 39-41
  • Acknowledgement Compliant
• [Journal Article] A facile synthesis of (5-siloxymethy)pyrrolidine-2-carboxylic acid ester (2015)
  • Author(s): Y. Yasuno, Y. Yoshida, A. Nishimura, Y. Ohfune, T. Shinada
  • Journal Title: Heterocycles Volume: 91 Issue: 12 Pages: 2377-2385
  • DOI: 10.3987/com-15-13347
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• [Journal Article] Cation-stitching cascade: exquisite control of terpene cyclization in cyclooctatin biosynthesis (2015)
  • Author(s): Sato, H., Teramoto, K., Masumoto, Y., Tezuka, N., Sakai, K., Ueda, S., Totsuka, Y., Shinada, T., Nishiyama, M., Wang, C., Kuzuyama, T., Uchiyama, M.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 18471-18471
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• [Journal Article] テルペン環化がおもしろい! - 驚きの連続反応機構と新規環化触媒 (2015)
  • Author(s): 保野陽子・品田哲郎
  • Journal Title: 化学 Volume: 70 Pages: 66-67
• [Journal Article] Cyclopropanation of E-dehydroaspartic acid esters with furan derivatives: The synthesis of highly functionalized α-2,3-methanoamino acid esters (2015)
  • Author(s): A. Manabe, R. Matsumoto, T. Shinada
  • Journal Title: Synlett Volume: 26 Issue: 12 Pages: 1710-1714
  • DOI: 10.1055/s-0034-1380812
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• [Journal Article] Biosynthesis of sesterterpene, head-to-tail triterpene, and sesquarterpene in Bacillus clausii: Identification of multifunctional enzymes and analysis of isoprenoid metabolites (2015)
  • Author(s): Ueda, D., Yamaga, H., Murakami, M., Totsuka, Y., Shinada, T., Sato, T.
  • Journal Title: ChemBiolChem Volume: 16 Issue: 9 Pages: 1710-1714
  • DOI: 10.1002/cbic.201500138
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• [Journal Article] 18F-AV45(Florbetapir F18)を用いた認知症における脳アミロイドイメージング (2015)
  • Author(s): 柴田俊秀・米澤久司・高橋純子・工藤雅子・小原智子・鈴木真紗子・石塚直樹・藤澤豊・佐々木敏秋・寺崎一典・世良耕一郎・寺山靖夫
  • Journal Title: 脳循環代謝 Volume: 26 Pages: 11-18
  • NAID: 130005093691
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• [Journal Article] 認知症への取り組み 認知症疾患医療センターからみた地域連携 (2015)
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  • Journal Title: 認知症への取り組み 認知症疾患医療センターからみた地域連携 Volume: 30 Pages: 46-50
• [Journal Article] Phenylboronic acid-based 19F MRI probe for the detection and imaging of hydrogen peroxide utilizing its large chemical-shift change (2015)
  • Author(s): Nonaka, H., An, Q., Sugihara, F., Doura, T., Tsuchiya, A., Yoshioka, Y., Sando, S.
  • Journal Title: Analytical Sciences Volume: 31 Pages: 331-335
  • NAID: 130005061536
  • Peer Reviewed / Open Access
• [Journal Article] A Novel Peroxisome Proliferator-activated Receptor (PPAR)α Agonist and PPARγ Antagonist, Z-551, Ameliorates High-fat Diet-induced Obesity and Metabolic Disorders in Mice. (2015)
  • Author(s): Shiomi Y, Yamauchi T, Iwabu M, Okada-Iwabu M, Nakayama R, Orikawa Y, Yoshioka Y, Tanaka K, Ueki K, Kadowaki T
  • Journal Title: J Biol Chem Volume: 290 Issue: 23 Pages: 14567-14581
  • DOI: 10.1074/jbc.m114.622191
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• [Journal Article] A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model (2015)
  • Author(s): Arima, Y., D. Kamimura, T. Atsumi, M. Harada, T. Kawamoto, N. Nishikawa, A. Stofkova1, T. Ohki, K. Higuchi, Y. Morimoto, P. Wieghofer, Y. Okada, Y. Mori, S. Sakoda, S. Saika, Y. Yoshioka, I. Komuro, T. Yamashita, T. Hirano, M. Prinz, M. Murakami.
  • Journal Title: eLife Volume: 4 Pages: 1-23
  • DOI: 10.7554/elife.08733
  • NAID: 120005757989
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• [Journal Article] タイムラプスMR画像におけるマクロファージ追跡へのハンガリアン法の適用 (2015)
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• [Journal Article] Facile synthesis of deuterium-labelled geranylgeraniols (2015)
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  • NAID: 130005064985
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• [Journal Article] Total Synthesis of a Monomeric Phloroglucinol Derivative Isolated from <i>Myrtus communis</i> (2015)
  • Author(s): Nishimura, E., Ohfune, Y. and Shinada, T.
  • Journal Title: Chemistry Letters Volume: 44 Issue: 4 Pages: 445-447
  • DOI: 10.1246/cl.141168
  • NAID: 130005062135
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  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] An unusaual terpene cyclization mechanism involving a carbon-carbon bond rearrangement (2015)
  • Author(s): Meguro, A., Motoyoshi, Y., Teramoto, K., Ueda, S., Totsuka, Y., Tomita, T., Kim, S.-Y., Kimura, T. Igarashi, M., Sawa, R., Shinada, T., Nishiyama, M. and Kuzuyama, T.
  • Journal Title: Angewandte Chemie Volume: 127 Issue: 14 Pages: 4427-4430
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• [Journal Article] Total synthesis structure elucidation of (+)-triumphalone (+)-isotriumphalone (2015)
  • Author(s): Nishimura, E., Ohfune, Y. and Shinada, T.
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• [Journal Article] Detection of changes in the locus coeruleus in patients with mild cognitive impairment and Alzheimer's disease: High-resolution fast spin-echo T1weighted imaging (2015)
  • Author(s): Takahashi, J., Shibata, T., Sasaki, M., Kudo, M., Yanezawa, H., Obara, S., Kudo, K., Ito, K., Yamashita, F. and Terayama, Y.
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  • Author(s): Ito, K., Sasaki, MM., Takahashi, J., Uwano, I., Yamashita, F., Higuchi, S., Goodwin, J., Harada, T., Kudo, K. and Terayama, Y.
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  • Author(s): Abe, S., Yamamoto, K., An, Y., Saeki, J., Itagaki, T., Kofujita, H. and Suzuki, K.
  • Journal Title: Journal of Insect Biotechnology and Sericology Volume: 83 Pages: 77-81
  • NAID: 130005071351
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  • Author(s): 御領政信・倉持 好・佐々木 淳
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• [Journal Article] Short Total Synthesis of (-)-Kainic Acid, (2014)
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  • Journal Title: Org. Lett. Volume: 16 Issue: 9 Pages: 2550-2553
  • DOI: 10.1021/ol5009526
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Solid Phase Synthesis of α-Amino Squaric Acid-containing Peptides (2014)
  • Author(s): K. Maeda, Y. Kiniwa, Y. Ohfune, S. Ishiguro, K. Suzuki, K. Murata, H. Matsuda T. Shinada
  • Journal Title: RSC Adv. Volume: 4 Issue: 92 Pages: 50639-50643
  • DOI: 10.1039/c4ra10442k
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 18Ｆ-ＡＶ45（Ｆｌｏｒｂｅｔａｐｉｒ）を用いた脳アミロイドイメージング (2014)
  • Author(s): 工藤雅子・米澤久司・柴田俊秀・小原智子・高橋純子・佐々木敏秋・寺崎一典・世良耕一郎・寺山靖夫
  • Journal Title: 脳循環代謝 Volume: 25 Pages: 91-96
  • NAID: 130004708209
  • Peer Reviewed / Open Access
• [Journal Article] Olfactory plays a key role in spatiotemporal pathogenesis of cerebral malaria. (2014)
  • Author(s): H. Zhao, T. Aoshi, S. Kawai, Y. Mori, A. Konishi, M. Ozkan, Y. Fujita, Y. Haseda, M. Shimizu, M. Kohyama, K. Kobiyama, K. Eto, J. Nabekura, T. Horii, T. Ishino, M. Yuda, H. Hemmi, T. Kaisho, S. Akira, M. Kinoshita, K. Tohyama, Y. Yoshioka, K. J. Ishii, C. Coban
  • Journal Title: Cell Host Microbe Volume: 15 Issue: 5 Pages: 551-563
  • DOI: 10.1016/j.chom.2014.04.008
  • Peer Reviewed / Open Access
• [Journal Article] In vivo magnetic resonance imaging at 11.7 Tesla visualized the effects of neunatal transection of infaraorbital nerve upon primary and secondary trigeminal pathways in rats (2014)
  • Author(s): Ooi, Y., Inui-Yamamoto, C., Suzuki, T., Nakadate, H., Nagase, Y., Seiyama, A., Yoshioka, Y. and Seki, J.
  • Journal Title: Brain Research Volume: 1579 Pages: 84-92
  • DOI: 10.1016/j.brainres.2014.07.013
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Diffusion tensor imaging of barin abnormalities induced by prenatal exposure to radiation in rodents (2014)
  • Author(s): Saito, S., Sawada, K., Hirose, M., Mori, Y., Yoshioka, Y. and Murase, K.
  • Journal Title: PLoS ONE Volume: 9 (9) Issue: 9 Pages: e107368-e107368
  • DOI: 10.1371/journal.pone.0107368
  • Peer Reviewed / Open Access
• [Journal Article] A new mouse allele of glutamate receptor delta 2 with cerebellar atrophy and progressive ataxia (2014)
  • Author(s): Miyoshi, Y., Yoshioka, Y., Suzuki, K., Miyazaki, T., Koura, M., Saigoh, K., Kajimura, N., Monobe,Y., Kusunoki, S., Matsuda, J., Watanabe, M. and Hayakawa, N.
  • Journal Title: PLoS ONE Volume: 9 (9) Issue: 9 Pages: 1-12
  • DOI: 10.1371/journal.pone.0107867
  • Peer Reviewed / Open Access
• [Journal Article] A short-wavelength infrared emiting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice (2014)
  • Author(s): Tsukasaki, Y., Komatsuzaki, A., Mori, Y., Ma, Q., Yoshioka, Y. and Jin, T.
  • Journal Title: Chemical Communication Volume: 50 Issue: 92 Pages: 14356-14359
  • DOI: 10.1039/c4cc06542e
  • Peer Reviewed / Open Access
• [Journal Article] From cartoon to real time MRI: in vivo monitoring of phagocyte migartion in mousse brain (2014)
  • Author(s): Mori, Y., Chen, T., Fujisawa, T., Kobashi, S., Ohno, K., Yoshida, S., Tago, Y., Komai, Y., Hata, Y. and Yoshioka, Y.
  • Journal Title: Scientific Reports Volume: 4 Issue: 1 Pages: 6997-6997
  • DOI: 10.1038/srep06997
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Cyclolavanduly skeleton biosynthesis via both condensation and cyclization catalyzed by an unprecedented member of cis-isoprenyl diphosphate synthase superfamily (2014)
  • Author(s): Ozaki T., Zhao P., Shinada T., Nishiyama M., Kuzuyama T.
  • Journal Title: Journal of the Amerikan Chemical Society Volume: in press
  • Peer Reviewed
• [Journal Article] Isolation of Maedi/Visna virus from a sheep in Japan (2014)
  • Author(s): Oguma K., Tanaka C., Harasawa R., Kimura A., Sasaki J., Goryo M. , Sentsui H.
  • Journal Title: The Journal of Veterinary Medical Science Volume: 76 Pages: 211-218
  • NAID: 130003382361
  • Peer Reviewed
• [Journal Article] 昆虫を資源とした生物学に基づくセラピーならびに創薬（その3） (2014)
  • Author(s): 鈴木幸一、ピヤマース・シラパコング、苅間澤真弓
  • Journal Title: PHRM TECH JAPAN Volume: 30 Pages: 459-462
• [Journal Article] Early pathological alterations of lower lumber cords detected by ultra-high field MRI in a mouse multiple sclerosis model. (2014)
  • Author(s): Mori, Y, M. Murakami, Y. Arima, D. Zhu, Y. Terayama, Y. Komai, Y. Nakatsuji, D. Kamimura, and Y. Yoshioka
  • Journal Title: Int Immunol. Volume: 26 Issue: 2 Pages: 93-101
  • DOI: 10.1093/intimm/dxt044
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 昆虫を資源とした生物学に基づくセラピーならびに創薬（その2） (2014)
  • Author(s): 鈴木幸一、石黒慎一
  • Journal Title: PHRM TECH JAPAN Volume: 30 Pages: 35-39
• [Journal Article] 昆虫を資源とした生物学に基づくセラピーならびに創薬（その4） (2014)
  • Author(s): 鈴木幸一、青木光広
  • Journal Title: PHRM TECH JAPAN Volume: 30 Pages: 651-655
• [Journal Article] Mulberry twig extract counters hair aging in senscence-acclerated mice (2013)
  • Author(s): Xu P., Uchidate M., Iwabuchi A., Kondo H., Matsui Y., Mangetsu M., Sasaki J., Goryo M., Kofujita H., Suzuki K.
  • Journal Title: Journal of Traditional Medicines Volume: 30 Pages: 229-235
  • Peer Reviewed
• [Journal Article] 昆虫を資源とした生物学に基づくセラピーならびに創薬（その1） (2013)
  • Author(s): 鈴木幸一、対馬正秋
  • Journal Title: PHRM TECH JAPAN Volume: 29 Pages: 2777-2781
• [Journal Article] Identification of Novel Sesterterpene/Triterpene Synthase from Bacillus clausii (2013)
  • Author(s): T. Sato, H. Yamaga, S. Kashima, Y. Murata, T. Shinada, C. Nakano, T. Hoshino
  • Journal Title: ChemBioChem Volume: 14 Issue: 7 Pages: 822-825
  • DOI: 10.1002/cbic.201300035
  • Peer Reviewed
• [Journal Article] Noninvasive measurement of human brain temperature adjacent to arteriovenous malformation using 3.0 T magnetic resonance spectroscopy (2013)
  • Author(s): Inoue T., Shimizu H., Fujimura M., Saito A., Yoshioka Y., Matsuda T., Tominaga T.
  • Journal Title: Clinical Neurology and Neurosurgery Volume: 115 Issue: 4 Pages: 445-449
  • DOI: 10.1016/j.clineuro.2012.06.022
  • Peer Reviewed
• [Journal Article] Postoperative changes in cerebral metabolites associated with cognitive improvement and impairment after cartid endarterectomy: A 3T proton MR spectroscopy study (2013)
  • Author(s): Saito H., Ogasawara K., Nishimoto H., Yoshioka Y., Murakami H., Fujiwara S., Sasaki M., Kobayashi M., Yoshida K., Kubo Y., Beppu T., Ogawa A.
  • Journal Title: American Journal of Neuroradiology Volume: 34 Issue: 5 Pages: 976-982
  • DOI: 10.3174/ajnr.a3344
  • Peer Reviewed
• [Journal Article] Activation of efferents from the basolateral amygdala during the retrieval of conditioned taste aversion (2013)
  • Author(s): Inui T., Inui-Yamamoto C., Yoshioka Y., Ohzawa I., Shimura T.
  • Journal Title: Neurobiology of Learning and Memory Volume: 106 Pages: 210-220
  • DOI: 10.1016/j.nlm.2013.09.003
  • Peer Reviewed
• [Journal Article] Metabolome analysis of food-chain between palnts and insects. (2013)
  • Author(s): Miyagi, A., Kawai-Yamada, M., Uchiyama, M., Ojima, N., Suzuki, K. and Uchiyama, H.
  • Journal Title: Metabolomoics Volume: 9 Issue: 6 Pages: 1254-1261
  • DOI: 10.1007/s11306-013-0542-9
  • Peer Reviewed
• [Journal Article] Stereoselective Synthesis of (E)-α,β-Dehydroamino Acid Esters (2013)
  • Author(s): Y. Yasuno, M. Hamada, T. Yamada, T. Shinada, Y. Ohfune
  • Journal Title: Eur. J. Org. Chem. Volume: 2013 Issue: 10 Pages: 1884-1888
  • DOI: 10.1002/ejoc.201300112
  • Peer Reviewed
• [Presentation] Total synthesis of paracentrone (2016)
  • Author(s): Nishioka, Y., Yano, Y., Kinashi, N., Oku, N., Toriyama, Y., Katsumura, S., Shinada, T., Sakaguchi, K.
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス
  • Year and Date: 2016-03-24
• [Presentation] Synthesis of fluorescent-labelled kaitocephalin (2016)
  • Author(s): Yoshida, K., Yasuno, Y., Ohfune, Y., Shinada, T.
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス
  • Year and Date: 2016-03-24
• [Presentation] Total synthesis of cirratiomycin A and B (2016)
  • Author(s): Nishimura, A., Yasuno, Y., Shinada, T.
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス
  • Year and Date: 2016-03-24
• [Presentation] Synthetic study of tetrodotoxin by a furan diels-alder reaction approach (2016)
  • Author(s): Ueda, S., Manabe, A., Shinada, T.
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス
  • Year and Date: 2016-03-24
• [Presentation] 海洋性カロテノイドであるフコキサンチンの類縁体（パラセントロン）のフェムト秒時間分解吸収分光 (2016)
  • Author(s): 橋本秀樹・行平奈央・藤原正澄・西岡 勇人・品田 哲郎・坂口和彦・勝村成雄
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス
  • Year and Date: 2016-03-24
• [Presentation] 紅色光合成細菌 Rs. rubrum の LH1 サブユニット型複合体とフコキサンチンを用いた再構成LH1 複合体のフェムト秒時間分解吸収分光 (2016)
  • Author(s): 行平奈央・須貝祐子・藤原正澄・浦上千藍紗・伊波匡彦・坂口和彦・勝村成雄・橋本秀樹
  • Organizer: 日本化学会第96春季年会
  • Place of Presentation: 同志社大学京田辺キャンパス
  • Year and Date: 2016-03-24
• [Presentation] 磁気共鳴スペクトロスコピーによるダイナミックなヒト脳内温度変化の非侵襲的測定 (2016)
  • Author(s): 吉岡芳親
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター
  • Year and Date: 2016-03-22
• [Presentation] カイコ冬虫夏草の安全性試験 (2016)
  • Author(s): シラパコング＝ピヤマース・石黒慎一・苅間澤真弓・江幡真規子・御領政信・佐々木 淳・小田伸一・西村栄治・品田哲郎・鈴木幸一
  • Organizer: 平成28年度蚕糸・昆虫機能利用学術講演会（日本蚕糸学会第86回大会）
  • Place of Presentation: 京都工芸繊維大学松ヶ崎キャンパス
  • Year and Date: 2016-03-17
• [Presentation] Total synthesis of paracentrone (2016)
  • Author(s): Nishioka, Y,, Yano, Y., Kinashi, N., Oku, N., Toriyama, Y., Katsumura, S., Shinada, T., Sakaguchi, K.
  • Organizer: 7th OCARINA International Symposium in conjunction with Symposium in honor of Distinguished Professor Michael Nobel（
  • Place of Presentation: Media Center and Library, Osaka City University
  • Year and Date: 2016-03-17
  • Int'l Joint Research
• [Presentation] Synthetic study of SF-2132? (2016)
  • Author(s): Sawai, A., Nishimura, A., Yasuno, Y., Shinada, T.
  • Organizer: 7th OCARINA International Symposium in conjunction with Symposium in honor of Distinguished Professor Michael Nobel
  • Place of Presentation: Media Center and Library, Osaka City University
  • Year and Date: 2016-03-17
  • Int'l Joint Research
• [Presentation] Synthetic study of phomopsin A (2016)
  • Author(s): Karita, Y.,Yasuno, Y,, Shinada, T.
  • Organizer: 7th OCARINA International Symposium in conjunction with Symposium in honor of Distinguished Professor Michael Nobel
  • Place of Presentation: Media Center and Library, Osaka City University
  • Year and Date: 2016-03-17
  • Int'l Joint Research
• [Presentation] Synthetic study of naturido (2016)
  • Author(s): Sakai, K., Yasuno, Y., Shinada, T.
  • Organizer: 7th OCARINA International Symposium in conjunction with Symposium in honor of Distinguished Professor Michael Nobel
  • Place of Presentation: Media Center and Library, Osaka City University
  • Year and Date: 2016-03-16
  • Int'l Joint Research
• [Presentation] デヒドロアミノ酸の立体制御と天然物全合成への展開 (2016)
  • Author(s): 品田哲郎
  • Organizer: 有機合成2月セミナー、有機合成のニュートレンド
  • Place of Presentation: 大阪科学技術センター
  • Year and Date: 2016-02-03
  • Invited
• [Presentation] Synthesis of fluorescent ligand for visualization of native ionotropic glutamate receptors (2015)
  • Author(s): Shinada, T.
  • Organizer: The 2015 International Chemical Congress of Pacific Basin Societies,
  • Place of Presentation: Honolulu, Hawaii
  • Year and Date: 2015-12-15
  • Invited
• [Presentation] 昆虫毒の多様性：その選択性と特異性 (2015)
  • Author(s): 品田哲郎
  • Organizer: 第38回日本分子生物学会年会, 第88回日本生化学会大会合同大会
  • Place of Presentation: 神戸ポートピアホテル
  • Year and Date: 2015-12-01
  • Invited
• [Presentation] Tri-modal imaging techniques Cathodoluminescence (CL) &#8211; Near Infrared (NIR) and Magnetic resonance imaging (MRI) with lanthanides doped Gd2O3 (2015)
  • Author(s): Kim, D.D.T., Fukushima, S., Furukawa, T., Niioka, H., Ichimiya, M., Ashida, M., Mori, Y., Yoshioka, Y., Hashimoto, M., Miyake, J.
  • Organizer: The 2nd East-Asia Microscopy Conference (The Himeji Chamber of Commerce and Industry (HCCI)
  • Place of Presentation: Himeji
  • Year and Date: 2015-11-24
• [Presentation] テトロドトキシンの触媒的不斉全合成研究 (2015)
  • Author(s): 上田翔太・真鍋敦・品田哲郎
  • Organizer: 第45回複素環化学討論会
  • Place of Presentation: 早稲田大学国際会議場
  • Year and Date: 2015-11-19
• [Presentation] Mouse brain macrophage tracking using hungarian algorithm in time-lapse MR images (2015)
  • Author(s): Tashita, A., Kobashi, S., Mori, Y., Morimoto, M., Aikawa, S., Yoshioka, Y., Hata, Y.
  • Organizer: The 7th International Conference on Emerging Trends in Engineering & Technology
  • Place of Presentation: Kobe
  • Year and Date: 2015-11-18
• [Presentation] 超高磁場MRIを用いたリンパ系の可視化と免疫細胞追跡 (2015)
  • Author(s): 吉岡芳親
  • Organizer: 第17回SNNS研究会学術集会; シンポジウム２「癌の転移を識る 基礎研究の最前線」
  • Place of Presentation: ワークピア横浜
  • Year and Date: 2015-11-13
• [Presentation] Brain activation induced by conditioned aversive saccharin solution in the retrieval of the conditioned taste aversion with lipopolysaccharide (2015)
  • Author(s): Inui-Yamamoto, C., Sugihara, F., Yoshioka, Y.
  • Organizer: The 13th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Perception (YR Umami Forum 2015)
  • Place of Presentation: Fukuoka
  • Year and Date: 2015-11-03
• [Presentation] 18F-AV45(Florbetapir)によるSUVR値とeZIS z-score値との比較検討 (2015)
  • Author(s): 柴田俊秀・米澤久司・高橋純子・工藤雅子・小原智子・鈴木真紗子・寺崎一典・佐々木敏秋・世良耕一郎・寺山靖夫
  • Organizer: 第27回日本脳循環代謝学会総会
  • Place of Presentation: 富山
  • Year and Date: 2015-10-30
• [Presentation] 地域の医師会会員を対象とした認知症診療に関する意識調査 (2015)
  • Author(s): 赤坂博・高橋純子・石塚直樹・藤澤豊・鈴木真紗子・小原智子・柴田俊秀・工藤雅子・米澤久司・寺山靖夫
  • Organizer: 第34回日本認知症学会学術集会
  • Place of Presentation: 青森
  • Year and Date: 2015-10-02
• [Presentation] カイコ冬虫夏草に由来する海馬修復因子の精製と機能解析 (2015)
  • Author(s): 石黒慎一・Piyamas Sillapakong・苅間澤真弓・江幡真規子・佐々木謙吾・高橋真奈美・漆畑拓弥・若林篤光・松浦哲也・品田哲郎・鈴木幸一
  • Organizer: 平成27年度蚕糸・昆虫機能利用学術講演会（日本蚕糸学会第85回大会）
  • Place of Presentation: 北海道大学農学部
  • Year and Date: 2015-09-26
• [Presentation] MRIによる多様な生体情報の抽出と活用 (2015)
  • Author(s): 吉岡芳親
  • Organizer: 第32回大阪大学医工情報連携シンポジウム
  • Place of Presentation: 大阪大学中之島センター
  • Year and Date: 2015-09-25
• [Presentation] リポポリサッカリドによる味覚嫌悪条件づけ時の脳幹における神経応答 (2015)
  • Author(s): 乾千珠子・杉原文徳・吉岡芳親
  • Organizer: 第49回日本味と匂学会大会
  • Place of Presentation: じゅうろくプラザ, 岐阜
  • Year and Date: 2015-09-24
• [Presentation] Bacillus clausiiにおけるセスタテルペン, head-to-tailトリテルペンおよびセスクアテルペンの生合成：多機能性酵素の同定とイソプレノイド代謝物の解析 (2015)
  • Author(s): 上田大次郎・山鹿宏彰・村上瑞気・遠塚悠輔・品田哲郎・佐藤努
  • Organizer: 第25回イソプレノイド研究会例会
  • Place of Presentation: 東北大学片平さくらホール
  • Year and Date: 2015-09-14
• [Presentation] アリル基質同士の縮合と環化反応を触媒する新奇テルペン合成酵素の発見 (2015)
  • Author(s): 小林正弥・尾﨑太郎・趙平・富田武郎・苅田祐馬・保野陽子・西村栄治・品田哲郎・西山真・葛山智久
  • Organizer: 第25回イソプレノイド研究会例会
  • Place of Presentation: 東北大学片平さくらホール
  • Year and Date: 2015-09-14
• [Presentation] 放線菌由来ジテルペン環化酵素CotB2の特異な環化反応機構の解明 (2015)
  • Author(s): 寺本和矢・目黒亜由子・本吉祐大・上田翔太・遠塚悠輔・安藤祐美・坂井健太・富田武郎・金承榮・木村智之・五十嵐雅之・澤竜一・品田哲郎・西山真・葛山智久
  • Organizer: 第25回イソプレノイド研究会例会
  • Place of Presentation: 東北大学片平さくらホール
  • Year and Date: 2015-09-14
• [Presentation] SPIOを用いたループス腎炎の評価 (2015)
  • Author(s): 陳挺・森勇樹・程振宇・Lee, S.・ Ripley, B・岸本忠三・乾千珠子・多胡善幸・ 吉田慎一・大野工司・吉岡芳親
  • Organizer: 第43日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームシティ
  • Year and Date: 2015-09-10
• [Presentation] 一酸化中毒亜急性期における白質障害と脳温との関係 (2015)
  • Author(s): 藤原俊朗・吉岡芳親・松田豪・西本英明・村上寿孝・南波孝昌・小川 彰・小笠原邦昭・別府高明
  • Organizer: 第43日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームシティ
  • Year and Date: 2015-09-10
• [Presentation] 一酸化中毒急性期・亜急性期における脳温 (2015)
  • Author(s): 藤原俊朗・吉岡芳親・松田 豪・西本英明・村上寿孝・小川 彰・小笠原邦昭・別府高明
  • Organizer: 第43日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームシティ
  • Year and Date: 2015-09-10
• [Presentation] 脳温計測のためのクモ膜下腔 DWI thermometry の開発 (2015)
  • Author(s): 藤原俊朗・吉岡芳親・松田 豪・西本英明・村上寿孝・小川 彰・小笠原邦昭・別府高明
  • Organizer: 第43日本磁気共鳴医学会大会
  • Place of Presentation: 東京ドームシティ
  • Year and Date: 2015-09-10
• [Presentation] Cirratiomycin Aの全合成 (2015)
  • Author(s): 西村彰人・安川佳史・保野陽子・大船泰史・品田哲郎
  • Organizer: 第57回天然有機化合物討論会
  • Place of Presentation: 神奈川県民ホール
  • Year and Date: 2015-09-09
• [Presentation] 共役ケトンを有するアポカロテノイド類の全合成研究 (2015)
  • Author(s): 西岡勇人・奥菜津未・勝村成雄・品田哲郎・坂口和彦
  • Organizer: 第59回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 近畿大学
  • Year and Date: 2015-09-05
• [Presentation] デオキシペリジニンの合成研究 (2015)
  • Author(s): 坂口和彦・木梨尚人・Fran, H.・勝村成雄・品田哲郎
  • Organizer: 第59回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 近畿大学
  • Year and Date: 2015-09-05
• [Presentation] Cirratiomycin Aの全合成 (2015)
  • Author(s): 西村彰人・保野陽子・安川佳史・品田哲郎
  • Organizer: 第31回若手化学者のための化学道場
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2015-08-27
• [Presentation] 不斉有機触媒を用いたβ-ニトロアクリレートとフランの不斉Diels-Alder反応の開発 (2015)
  • Author(s): 上田翔太・品田哲郎
  • Organizer: 第31回有機化学者のための化学道場（
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2015-08-27
• [Presentation] 脳内温度測定と脳内温度変化から見た脳内エネルギー変化 (2015)
  • Author(s): 吉岡芳親
  • Organizer: 温熱生理研究会
  • Place of Presentation: 生理学研究所, 岡崎
  • Year and Date: 2015-08-26
• [Presentation] テルペン酵素反応機構の解明を指向した重水素化プローブの選択的合成 (2015)
  • Author(s): 坂井健太・苅田祐馬・上田翔太・遠塚悠輔・保野陽子・品田哲郎
  • Organizer: 第35回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 京都府立大学下鴨キャンパス
  • Year and Date: 2015-08-01
• [Presentation] 冬虫夏草由来の新規ペプチドの構造決定 (2015)
  • Author(s): 山口俊介・西村栄治・鳥山陽平・澤井 瑛・苅田祐馬・保野陽子・鈴木幸一・対馬正秋・品田哲郎
  • Organizer: 第35回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 京都府立大学下鴨キャンパス
  • Year and Date: 2015-08-01
• [Presentation] Cirratiomycin Aの全合成 (2015)
  • Author(s): 西村彰人・保野陽子・安川佳史・澤井瑛・品田哲郎
  • Organizer: 第35回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 京都府立大学下鴨キャンパス
  • Year and Date: 2015-08-01
• [Presentation] 不斉有機触媒を用いたβ-ニトロアクリレートとフランの不斉Diels-Alder反応の開発 (2015)
  • Author(s): 上田翔太・品田哲郎
  • Organizer: 第35回有機合成若手セミナー「明日の有機合成を担う人のために」
  • Place of Presentation: 京都府立大学下鴨キャンパス
  • Year and Date: 2015-08-01
• [Presentation] 超高磁場：MRイメージングを用いた生体脳内免疫細胞動態追跡 (2015)
  • Author(s): 森勇樹・吉岡芳親
  • Organizer: 第67回日本細胞生物学会大会; シンポジウム6「個体中の細胞動態の定量的な解析Quantitative analysis of in vivo Cellular dynamics」
  • Place of Presentation: タワーホテル船堀
  • Year and Date: 2015-06-30
• [Presentation] Relationship between brain temperature and white matter damage in subacute carbon monoxide poisoned patients (2015)
  • Author(s): Fujiwara, S., Yoshioka, Y., Matsuda, T., Nishimoto, H., Murakami, T., Nanba, T., Ogawa, A., Ogasawara, K., Beppu, T.
  • Organizer: The 1st Congress of the European Academy of Neurology (EAN Berlin 2015),
  • Place of Presentation: Berlin
  • Year and Date: 2015-06-20
• [Presentation] Synthetic study of kainoid analogs via intramolecular radical cyclization reaction (2015)
  • Author(s): Shinada, T., Yamada, A.
  • Organizer: 新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第8回公開シンポジウム
  • Place of Presentation: 東北大学片平キャンパス
  • Year and Date: 2015-06-08
• [Presentation] The intraoral stimulus increases the regional brain temperature in the insular cortex of rats: a proton MR spectroscopy study (2015)
  • Author(s): Inui-Yamamoto, C., Shimura, T., Ohzawa, I., Yoshioka, Y.
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto
  • Year and Date: 2015-05-30
• [Presentation] Diffusion-weighted thermometry using subarachnoid space cerebrospinal fluid in subacute carbon monoxide poisoning patients (2015)
  • Author(s): Fujiwara, S., Yoshioka Y., Matsuda, T., Nishimoto, H., Murakami, T., Ogawa, A., Ogasawara, K., Sasaki, M., Beppu, T.
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto
  • Year and Date: 2015-05-30
• [Presentation] Visualization of lupus nephritis using SPIO (2015)
  • Author(s): Chen, T., Mor,i Y., Cheng, Z., Lee, S., Ripley, B., Kishimoto, T., Inui-Yamamoto, C., Sugihara, F., Kitagak,i N., Tago, Y., Yoshida, S., Ohno, K., Yoshioka, Y.
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto
  • Year and Date: 2015-05-30
• [Presentation] In vivo monitoring of immune cell kinetics with time-lapse MRI in the ischemic lesion of mouse brain (2015)
  • Author(s): Mori, Y., Chen, T., Yoshioka, Y.
  • Organizer: The 23rd Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Toronto
  • Year and Date: 2015-05-30
• [Presentation] Amyloid imaging of dementia using the radioligand 18F-AV45(Florbetapir F 18) (2015)
  • Author(s): Shibata, T., Yonezawa, H., Takahashi, J., Kudo, M., Obara, S., Suzuk,i M., Sasaki, T., Terasak,i K., Sera, K., Terayama, Y.
  • Organizer: 第56回日本神経学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] Alzheimer病およびMCI患者における記憶機能検査(WMS-R)成績の検討 (2015)
  • Author(s): 石塚直樹・鈴木真紗子・坂本暁恵・高橋純子・工藤雅子・米澤久司・寺山靖夫
  • Organizer: 第56回日本神経学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-20
• [Presentation] 磁気共鳴による深部体温測定 (2015)
  • Author(s): 吉岡芳親
  • Organizer: 第３回熊本大学イメージングセミナー
  • Place of Presentation: 熊本大学
  • Year and Date: 2015-05-08
• [Presentation] Detection of dynamical human brain temperature change during tasks and anesthsia (2015)
  • Author(s): Yoshioka, Y., Oikawa, H., Shinobe, Y., Joh, S. and Seki, J.
  • Organizer: 第92回日本生理学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Synthetic study of natural products with a cyclic tripeptide core (2015)
  • Author(s): Yasuno, Y., Yamaguchi, S., Shinada, T.
  • Organizer: The 18th Osaka City University International Conference
  • Place of Presentation: Osaka City University, Media Center
  • Year and Date: 2015-03-09
• [Presentation] 早期に認知症外来を受信するのはどういった症例か、外来初診患者の検討 (2014)
  • Author(s): 赤坂 博・高橋純子・藤沢 豊・鈴木真沙子・石塚直樹・柴田俊英・小原智子・工藤雅子・米澤久司・寺山靖夫
  • Organizer: 第33回日本認知症学会学術集会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-11-29 – 2014-12-01
• [Presentation] 18Ｆ-ＡＶ45（Florbetapir）を用いた認知症におけるアミロイドイメージング (2014)
  • Author(s): 柴田俊英・米澤久司・高橋純子・工藤雅子・鈴木真沙子・小原智子・寺崎一典・佐々木敏秋・世良耕一郎・寺山靖夫
  • Organizer: 第26回日本脳循環代謝学会総会
  • Place of Presentation: 岡山市
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 高度に官能基化された単環性Phloroglucinol類の全合成 (2014)
  • Author(s): 西村栄治・大船泰史・品田哲郎
  • Organizer: 第56回天然有機化合物討論会
  • Place of Presentation: 高知県民ホール
  • Year and Date: 2014-10-15 – 2014-10-17
• [Presentation] 加齢による苦味嗜好性の変化に関する脳部位の活動 (2014)
  • Author(s): 乾千珠子・乾 賢・山本 隆・上田甲寅・中塚美智子・隅部俊二・岩井康智・吉岡芳親
  • Organizer: 第48回日本味と匂学会大会
  • Place of Presentation: 静岡
  • Year and Date: 2014-10-02 – 2014-10-04
• [Presentation] プロポリス由来、新規テトラアルキルPhloroglucinol類の構造決定-1 (2014)
  • Author(s): 西村栄治・品田哲郎・大船泰史・鈴木幸一
  • Organizer: 第58回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 和歌山大学
  • Year and Date: 2014-09-20 – 2014-09-22
• [Presentation] プロポリス由来、新規テトラアルキルPhloroglucinol類の構造決定-2 (2014)
  • Author(s): 西村栄治・品田哲郎・大船泰史・鈴木幸一
  • Organizer: 第58回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 和歌山大学
  • Year and Date: 2014-09-20 – 2014-09-22
• [Presentation] Prospective motion correction を用いた高解像度fMRI：頭部動きの検討 (2014)
  • Author(s): 黄田育宏・上口貴志・松岡雄一郎・劉 国相・吉岡芳親・田口隆久
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] SPIO-induced signal changes correlated with EAE development in the lower lumbar spinal cord (2014)
  • Author(s): 程 振宇・森 勇樹・陳 挺・吉岡芳親
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] Time-lapse MRI によるダイナミックな脳内細胞動態追跡の検討 (2014)
  • Author(s): 森 勇樹・陳 挺・吉田将太・柏木雄人・小橋昌司・畑 豊・吉岡芳親
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 7T MRIの1H-MRSによる水-NAAの共鳴周波数変化を用いた温度計測 (2014)
  • Author(s): 東 高志・瀧澤 修・栗林秀人・中井隆介・吉岡芳親・森 勇樹・都賀谷紀宏・劉 国相
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] プロトンおよびリンMR信号を用いた7T MRIによる新しい温度測定法の開発 (2014)
  • Author(s): 東 高志・瀧澤 修・栗林秀人・中井隆介・吉岡芳親・都賀谷紀宏・劉 国相
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 小動物用11.7T MRI 装置で使用できる感染マウス用密閉コンテナの試作 (2014)
  • Author(s): 吉田将太・森 勇樹・陳 挺・程 振宇・吉岡芳親
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] 磁気性粒子を用いた糸球体腎炎モデルマウスの評価 (2014)
  • Author(s): 陳 挺・森 勇樹・程 振宇・大野工司・多胡善幸・吉田慎一・吉岡芳親
  • Organizer: 第42回日本磁気共鳴医学会大会
  • Place of Presentation: 京都
  • Year and Date: 2014-09-18 – 2014-09-20
• [Presentation] Non-invasive MRI monitoring of immune cell recruitment and migartion in mouse brain (2014)
  • Author(s): Mori, Y., Cheng, T., Fujisawa, T., Kobashi, S., Hata, Y. and Yoshioka, Y.
  • Organizer: The 37th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Yokohama
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] 超高磁場ＭＲＩを用いた生体内免疫細胞脳内浸潤の1細胞レベル可視化についての検討 (2014)
  • Author(s): 森 勇樹・陳 挺・大野工司・吉田慎一・多胡善幸・小橋昌司・畑 豊・吉岡芳親
  • Organizer: 第23回日本バイオイメージング学会学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-04 – 2014-09-06
• [Presentation] Synthetic study of higly oxygenated tetramethylphloroglucinols (2014)
  • Author(s): Nishimura, E., Ohfune, Y. and Shinada, T.
  • Organizer: 27th International Conference on Polyphenls
  • Place of Presentation: Nagoya University
  • Year and Date: 2014-09-02 – 2014-09-06
• [Presentation] Image alignment for single-cell imaging of macrophage in the mouse barin using 11.7 T MRI (2014)
  • Author(s): Kobayashi, S., Mori, Y., Yoshiokam Y. and Hata, Y.
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] In vivo MRI monitoring of inflammatory alternations and cellular dynamics in the central nervous system (2014)
  • Author(s): Mori, Y., Arima, Y., Chen, T., Zhu, D., Komai, Y., Nurakami, M., Yoshioka, Y. and Fujisawa, T.
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Near-infrared fluorescent nanoprobes for noninvasive multimodal tissue imaging (2014)
  • Author(s): Nakane, Y., Jin, T., Mori, Y., Yoshioka, Y. and Ma, Q.
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Neural substrates for the retrieval of conditioned taste aversion revealed by manganese-enhanced MRI (2014)
  • Author(s): Inui, T., Shimura, T., Inui-Yamamoto, C., Yoshioka, Y. and Ohzawa, I.
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Changes in regional brain temperature induced by increase in neuronal activity in rats (2014)
  • Author(s): Inui-Yamamoto, C., Shimura, T., Seiyama, A., Ohzawa, I. and Yoshioka, Y.
  • Organizer: World Automation Congress 2014
  • Place of Presentation: Kona, Hawaii, USA
  • Year and Date: 2014-08-03 – 2014-08-07
• [Presentation] Hisotological correlation of manganese enhanced MRI in the demyelinating disease model brain (2014)
  • Author(s): Fukunaga, M., Masumura, M., Koda, S.m Shimonaga, T., Nakamura, R/. Mori, Y. and Yoshioka, Y.
  • Organizer: The 22d Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milian, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] New magnetic nanoparticle for kidney function (2014)
  • Author(s): Yoshioka, Y., Chen, T., Mori, Y., Cheng, Z., Kashiwagi, Y., Fukunaga, M., Kida, I., Togo, Y., Yosida, S. and Ohnoe, K.
  • Organizer: The 22d Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milian, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] Sequential and time-lapse MRI monitoring of peripheral macrophage recruitment and migration in mouse barin (2014)
  • Author(s): Mori, Y., Chen, T., Ohno, K., Yosida, S., Tago, Y., Fujisawa, T., Kashiwagi, Y., Fukunaga, M., Komai, Y., Hata, Y. and Yoshioka, Y.
  • Organizer: The 22d Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Milian, Italy
  • Year and Date: 2014-05-10 – 2014-05-16
• [Presentation] キイロスズメバチの巣に含まれる生物活性分子 (2013)
  • Author(s): 品田哲郎、大船泰史、藤原由美子、鈴木幸一
  • Organizer: 第60回毒素シンポジウム
  • Place of Presentation: 兵庫県宍粟郡楓香荘
• [Presentation] Total synthesi of natural products exhibiting glutamate receptor binding activities (2013)
  • Author(s): Shinada T.
  • Organizer: The 15th Asian Chemical Congress (ACC)
  • Place of Presentation: Reports World Sentosa Singapore
  • Invited
• [Presentation] Brain temperature and brain energy changes during tasks and light anesthesia: estimation with MRS (2013)
  • Author(s): Yoshioka Y., Oikawa H., Kanbara Y., Matsumura Y., Inoue T., Shinohe Y., Joh S., Matsuda T., Nabetani A., Seki J.
  • Organizer: The 21st Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt Lake City, USA
• [Presentation] A novel four-channel phased array coil with a special shield for cardiac functional imaging (2013)
  • Author(s): Zhu D., Mori Y., Yoshioka Y.
  • Organizer: The 21st Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Temporal alaternations of lower-lumber spinal code in experimental autoimmune encephalomyelitis mice (2013)
  • Author(s): Mori Y., Murakami M., Arima Y., Zhu D., Yoshioka Y.
  • Organizer: The 21st Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Asymmetrical coordinate of vasculature but symmetrical gustatory representaion in left and right hemishpere of rodent brain (2013)
  • Author(s): Kida I., Hoshi Y., Nemoto M., Iguchi Y., Yoshioka Y.
  • Organizer: The 21st Annual Meeting of International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Salt Lake City, USA
• [Presentation] 磁性粒子を用いた末梢組織マクロファージの脳内浸潤の経時的観察 (2013)
  • Author(s): 森勇樹、陳挺、程振宇、大野工司、吉田慎一、多胡善幸、福永雅喜、吉岡芳親
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: アスティとくしま
• [Presentation] 新規酸化鉄造影剤とリゾビストのマウス体内分布の比較 (2013)
  • Author(s): 陳挺、程振宇、森勇樹、福永雅喜、黄田育宏、駒井豊、多胡善幸、吉田慎一、大野工司、吉岡芳親
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: アスティとくしま
• [Presentation] マンガン造影MRIによるクリプゾン誘発脱髄モデルの観察 (2013)
  • Author(s): 福永雅喜、升村誠、幸田修一、下永友和、森勇樹、吉岡芳親
  • Organizer: 第41回日本磁気共鳴医学会大会
  • Place of Presentation: アスティとくしま
• [Presentation] 固相合成によるα‐アミノスクアリン酸含有ペプチドの合成 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] シクロプロパン環を導入したジアミノピメリン酸の合成研究 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] 金触媒を用いた1‐アリ－ル‐3‐ブチン‐1‐オ－ル類の環化反応、置換ナフタレン類の合成 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] 高度にアルキル化されたフロログルシノール誘導体の合成研究 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] 鎖状テルペン側鎖置換型JHSB3アナログの合成 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] 長鎖ポリイソプレノイドの立体制御合成 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] 電子不足オレフィンとフラン誘導体を用いたシクロプロパン化反応 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] クロスカップリング反応を利用した3位置換‐2‐ピリドン‐6‐カルボン酸の合成研究 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] β,β-ジ置換α, β-デヒドロアミノ酸エステルの立体選択的合成法の開発 (2013)
  • Author(s): 品田哲郎
  • Organizer: 日本化学会第93春季年会
  • Place of Presentation: 立命館大学びわこ・くさつキャンパス
• [Presentation] クマバチ毒嚢由来の生物活性ペプチド (2012)
  • Author(s): 品田哲郎
  • Organizer: 第59回トキシンシンポジウム
  • Place of Presentation: 帯広市とかちプラザ
• [Presentation] スクアリン酸含有アミノ酸を組み込んだ新規ペプチドアナログ合成 (2012)
  • Author(s): 品田哲郎
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 東京農業大学世田谷キャンパス
• [Presentation] 鎖状テルペン側置換型JHSB3アナログの合成 (2012)
  • Author(s): 品田哲郎
  • Organizer: 第56回香料・テルペンおよび精油化学に関する討論会
  • Place of Presentation: 鹿児島大学
• [Presentation] 置換ピリドンカルボン酸類の新規合成法の開発 (2012)
  • Author(s): 品田哲郎
  • Organizer: 第42回複数環化学討論会
  • Place of Presentation: 京都テルサ
• [Presentation] 光学活性ピロリンの簡便な合成法の開発 (2012)
  • Author(s): 品田哲郎
  • Organizer: 第42回複数環化学討論会
  • Place of Presentation: 京都テルサ
• [Presentation] Regio- and streoselective functionalization of acyclic terpenes. (2012)
  • Author(s): Shinada, T.
  • Organizer: International Conference of Natural Products Biosynthesis (ICNPB)
  • Place of Presentation: Awaji Yumebitai, Japan
• [Presentation] Biological activity of juvenile hormone III skipped bisepoxide (JHSB3) in the stink bug, Plautia stali (2012)
  • Author(s): Shinada, T.
  • Organizer: 24th International Congress of Entomology
  • Place of Presentation: Deagu, Korea
• [Presentation] Structure activity relationship of a novel juvenile hormon, JHSB3 (2012)
  • Author(s): Shinada, T.
  • Organizer: 24th International Congress of Entomology
  • Place of Presentation: Deagu, Korea
• [Presentation] Development of selective ionotropic glutamate receptor binding antagonist: structure-activity relationship study of kaitocephalin (2012)
  • Author(s): Shinada, T.
  • Organizer: Th 1st International Symposium on Chemical Biology of Natural products: Target ID and Regulation of Bioactivity
  • Place of Presentation: Kyoto, Japan
• [Presentation] 「取り繕い応答」に着目した簡易記憶障害スクリーニング (2012)
  • Author(s): 寺山靖夫
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 18F－AV45（Flobetapir)を用いた脳アミロイドイメージング (2012)
  • Author(s): 寺山靖夫
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 磁気共鳴信号の多様性と超高磁場MRIの活用－個体レベルから細胞レベルまで
  • Author(s): 吉岡芳親
  • Organizer: 第15回大阪脳神経画像症例検討会
  • Place of Presentation: 新阪急ホテル
  • Invited
• [Presentation] 昆虫機能利用のための学術研究と応用開発-ヤママリン、アンチエイジング因子、海馬修復因子を基軸として
  • Author(s): 鈴木幸一
  • Organizer: 日本蚕糸学会合同大会昆虫機能・利用学術講演会
  • Place of Presentation: 信州大学繊維学部
  • Invited
• [Presentation] 天蚕の休眠覚醒に伴う噴門弁の形態と機能の変化
  • Author(s): 鈴木幸一
  • Organizer: 蚕糸・昆虫機能利用学会学術講演会
  • Place of Presentation: 農林水産技術会議事務局筑波事務所
• [Presentation] 幼若ホルモン（JHSB3)側鎖置換型アナログの合成
  • Author(s): 品田哲郎
  • Organizer: 第39回有機反応懇談会
  • Place of Presentation: 関西大学
• [Presentation] 金触媒環化反応による置換ナフタレンの合成
  • Author(s): 品田哲郎
  • Organizer: 第39回有機反応懇談会
  • Place of Presentation: 関西大学
• [Presentation] α‐アミノスクレアリン酸連結型ペプチドアナログの合成
  • Author(s): 品田哲郎
  • Organizer: 第39回有機反応懇談会
  • Place of Presentation: 関西大学
• [Presentation] 立体配座を固定した2,6-ジアミノピメリン酸誘導体の合成研究
  • Author(s): 品田哲郎
  • Organizer: 第39回有機反応懇談会
  • Place of Presentation: 関西大学
• [Presentation] 天然有機化合物を起点とする生物有機科学研究
  • Author(s): 品田哲郎
  • Organizer: 神戸薬科大学セミナー
  • Place of Presentation: 神戸薬科大学
• [Presentation] 非天然型アミノ酸構造を有する天然有機化合物の全合成研究
  • Author(s): 品田哲郎
  • Organizer: 第39回有機反応懇談会
  • Place of Presentation: 関西大学
• [Book] Handbook of Hormones-Comparative Endocrinology for Basic and Clinical Research (2016)
  • Author(s): Suzuki Koichi
  • Publisher: Elsevier Inc.
• [Book] 幕末に海を渡った養蚕書 (2016)
  • Author(s): 竹田敏著－鈴木幸一・木内信・塩月孝博編集
  • Total Pages: 138
  • Publisher: 東海大学出版部
• [Book] Fronties in Clinical Drug Research-Alzheimer Disorder, Vol.2 (2016)
  • Author(s): Suzuki, K., Tsushima, M., Goryo, M., Shinada, T., Yasuno, Y., Nishimura, E., Terayama, Y., Mori, Y., Yoshioka, Y.
  • Publisher: Bentham Science
• [Book] The reproductive system and gametogenesis of Bombyx mori- An ultrastructural pointo of view II (2015)
  • Author(s): Miya, K. (Edited by Suzuki, K., Goryo, M. and Yaginuma, T.)
  • Total Pages: 600
  • Publisher: Tokai University Press
• [Patent(Industrial Property Rights)] 環状ペプチド誘導体とその製造法および組成物 (2015)
  • Inventor(s): 鈴木幸一・品田哲郎・寺山靖夫・他7名
  • Industrial Property Rights Holder: 国立大学法人岩手大学、大阪市立大学、岩手医科大学、（株）ロッテ
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-09-18
  • Overseas
• [Patent(Industrial Property Rights)] 環状ペプチド誘導体とその製造方法および組成物 (2014)
  • Inventor(s): 鈴木幸一・品田哲郎・寺山靖夫・他7名
  • Industrial Property Rights Holder: 国立大学法人岩手大学・学校法人岩手医科大学・他2社
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-194509
  • Filing Date: 2014-09-24
• [Patent(Industrial Property Rights)] 複合粒子を含む腎機能診断用イメージング剤 (2014)
  • Inventor(s): 多胡善幸・吉田慎一・吉岡芳親・陣 挺・森 勇樹・大野工司
  • Industrial Property Rights Holder: 国立大学法人大阪大学・国立大学法人京都大学・（株）カネカ
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2014-181733
  • Filing Date: 2014-09-05
• [Patent(Industrial Property Rights)] 共振回路 (2012)
  • Inventor(s): 吉岡芳親・朱大松
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-05-24
  • Overseas
• [Patent(Industrial Property Rights)] ダイヤモンド複合粒子 (2012)
  • Inventor(s): 吉岡芳親・森田将史・清野智史・立川貴士・真嶋哲朗
  • Industrial Property Rights Holder: 大阪大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-246538
  • Filing Date: 2012-11-08
• [Patent(Industrial Property Rights)] 脳機能改善剤 (2012)
  • Inventor(s): 鈴木幸一他
  • Industrial Property Rights Holder: 岩手大学他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-051004
  • Filing Date: 2012-03-07