| Budget Amount *help |
¥49,010,000 (Direct Cost: ¥37,700,000、Indirect Cost: ¥11,310,000)
Fiscal Year 2013: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Fiscal Year 2012: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2011: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
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| Outline of Final Research Achievements |
The aim of this study is the establishment of design principle for the creation of artificial antigens for cellular immunity. For this purpose, we prepared the library for artificial proteins from combinatorial polymerization of "MHC class I epitope", "MHC class II epitope" and the "peptide sequences having the propensities to form secondary structures", from which we have successfully selected the clones that can efficiently evoke in vitro and in vivo cellular immunity without the co-addition of physical adjuvant such as mineral oil or aluminum hydroxide.
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