Nicher Regulation for Normal Hemopoietic Stem Cells and Leukemic Stem Cells
| Project/Area Number |
23249053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
SUDA Toshio 慶應義塾大学, 医学部, 教授 (60118453)
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| Co-Investigator(Kenkyū-buntansha) |
TAKUBO Keiyo 慶應義塾大学, 医学部, 専任講師 (50502788)
NAGAMATSU Go 慶應義塾大学, 医学部, 助教 (70453545)
HOSOKAWA Kentaro 慶應義塾大学, 医学部, 特任助教 (90569584)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2013: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2012: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2011: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
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| Keywords | 造血幹細胞 / 白血病幹細胞 / ニッチ / 活性酸素 / 低酸素 / 炎症 / プロスタグランディン / ニッチ因子 |
|---|
| Research Abstract |
Stem cell maintenance in a haltered cell-cycle state (i.e., quiescence) has been proposed as a fundamental property of HSCs. Maintenance of quiescence protects HSCs from functional exhaustion and naturally producing extrinsic cellular insults to enable lifelong hematopoietic cell production. HSC quiescence is regulated through a complex network of cell intrinsic regulations along with extrinsic influences from the microenvironment. Normal HSCs maintain intracellular hypoxia, stabilize the hypoxia-inducible factor-alpha(HIF-1a) protein and generate ATP by anaerobic metabolism. In HIF-1a-deficiency, HSCs became metabolically aerobic, lost cell cycle quiescence, and finally exhausted.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] The IL-2/CD25 Axis Maintains Distinct Subsets of Chronic M yeloid Leukemia-initiating Cells.2014
Author(s)
Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T.
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Journal Title
Blood
Volume: 123
Issue: 16
Pages: 2540-2549
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011
Author(s)
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
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Journal Title
J Exp Med
Volume: 208
Issue: 5
Pages: 949-960
DOI
Related Report
Peer Reviewed
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