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Nicher Regulation for Normal Hemopoietic Stem Cells and Leukemic Stem Cells

Research Project

Project/Area Number 23249053
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Hematology
Research InstitutionKeio University

Principal Investigator

SUDA Toshio  慶應義塾大学, 医学部, 教授 (60118453)

Co-Investigator(Kenkyū-buntansha) TAKUBO Keiyo  慶應義塾大学, 医学部, 専任講師 (50502788)
NAGAMATSU Go  慶應義塾大学, 医学部, 助教 (70453545)
HOSOKAWA Kentaro  慶應義塾大学, 医学部, 特任助教 (90569584)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2013: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2012: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2011: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Keywords造血幹細胞 / 白血病幹細胞 / ニッチ / 活性酸素 / 低酸素 / 炎症 / プロスタグランディン / ニッチ因子
Research Abstract

Stem cell maintenance in a haltered cell-cycle state (i.e., quiescence) has been proposed as a fundamental property of HSCs. Maintenance of quiescence protects HSCs from functional exhaustion and naturally producing extrinsic cellular insults to enable lifelong hematopoietic cell production. HSC quiescence is regulated through a complex network of cell intrinsic regulations along with extrinsic influences from the microenvironment. Normal HSCs maintain intracellular hypoxia, stabilize the hypoxia-inducible factor-alpha(HIF-1a) protein and generate ATP by anaerobic metabolism. In HIF-1a-deficiency, HSCs became metabolically aerobic, lost cell cycle quiescence, and finally exhausted.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (67 results)

All 2014 2013 2012 2011 Other

All Journal Article (34 results) (of which Peer Reviewed: 33 results,  Open Access: 4 results) Presentation (31 results) (of which Invited: 13 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress.2014

    • Author(s)
      Tai-Nagara I, Matsuoka S, Ariga H, Suda T
    • Journal Title

      Blood

      Volume: 123 Issue: 1 Pages: 41-50

    • DOI

      10.1182/blood-2013-06-508333

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The IL-2/CD25 Axis Maintains Distinct Subsets of Chronic M yeloid Leukemia-initiating Cells.2014

    • Author(s)
      Kobayashi CI, Takubo K, Kobayashi H, Nakamura-Ishizu A, Honda H, Kataoka K, Kumano K, Akiyama H, Sudo T, Kurokawa M, Suda T.
    • Journal Title

      Blood

      Volume: 123 Issue: 16 Pages: 2540-2549

    • DOI

      10.1182/blood-2013-07-517847

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hematopoietic stem cell aging and oxidative stress.2014

    • Author(s)
      Cheong J-W, Nakamura-Ishizu A, Nitta E, Suda T
    • Journal Title

      Stem Cells

      Volume: 1 Pages: 88-105

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Metabolic requirements for the maintenance of self-renewing stem cells.2014

    • Author(s)
      Ito K and Suda T
    • Journal Title

      Nat Rev Mol Cell Biol

      Volume: 15 Issue: 4 Pages: 243-256

    • DOI

      10.1038/nrm3772

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heterogeneity and hierarchy of hematopoietic stem cells.2014

    • Author(s)
      Ema H, Morita Y, Suda T
    • Journal Title

      Exp Hematol

      Volume: 42 Issue: 2 Pages: 74-82

    • DOI

      10.1016/j.exphem.2013.11.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.2013

    • Author(s)
      Nagamachi A
    • Journal Title

      Cancer Cell

      Volume: 24 Issue: 3 Pages: 305-317

    • DOI

      10.1016/j.ccr.2013.08.011

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hematopoietic stem cell niche: An interplay among a repertoire of multiple functional niches.2013

    • Author(s)
      Nakamura-Ishizu A and Suda T
    • Journal Title

      Biochem Biophys Acta

      Volume: 1830 Issue: 2 Pages: 2404-2409

    • DOI

      10.1016/j.bbagen.2012.08.023

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel interferon-based pre-transplantation conditioning in the treatment of a congenital metabolic disorder2013

    • Author(s)
      Sato T(他9名)
    • Journal Title

      Blood

      Volume: 121 Issue: 16 Pages: 3267-3273

    • DOI

      10.1182/blood-2012-07-443713

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.2013

    • Author(s)
      Takubo K
    • Journal Title

      Cell Stem Cell

      Volume: 12 Issue: 1 Pages: 49-61

    • DOI

      10.1016/j.stem.2012.10.011

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E2 regulates murine hematopoietic stem/progenitorcells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.2013

    • Author(s)
      Ikushima YM. Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T
    • Journal Title

      Blood

      Volume: 121(11) Issue: 11 Pages: 1995-2007

    • DOI

      10.1182/blood-2012-06-437889

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets.2013

    • Author(s)
      Matsubara Y, Ono Y, Suzuki H, Arai F, Suda T, Murata M, Ikeda Y
    • Journal Title

      PLoS One

      Volume: 8 Issue: 3 Pages: e58123-e58123

    • DOI

      10.1371/journal.pone.0058123

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Angptl/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.2013

    • Author(s)
      Ikushima YM. Arai F, Nakamura Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, Suda T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 130(1) Issue: 1 Pages: 20-25

    • DOI

      10.1016/j.bbrc.2012.11.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.2013

    • Author(s)
      Yamashita M, Nitta E, Nagamatsu G, Ikushima YM, Hosokawa K, Arai F, Suda T
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 441 Issue: 1 Pages: 196-201

    • DOI

      10.1016/j.bbrc.2013.10.032

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of pluripotent stem cells by each of the known reprogramming factors from primordial germ cells.2013

    • Author(s)
      Nagamatsu G
    • Journal Title

      Stem Cells

      Volume: 31 Issue: 3 Pages: 479-487

    • DOI

      10.1002/stem.1303

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche2012

    • Author(s)
      Arai F(他4名)
    • Journal Title

      Ann NYAcad Sci

      Volume: 1266 Pages: 72-77

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3566224/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance2012

    • Author(s)
      Ito K(他10名)
    • Journal Title

      Nat Med

      Volume: 18 Issue: 9 Pages: 1350-1358

    • DOI

      10.1038/nm.2882

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche2012

    • Author(s)
      Sugimura R(他10名)
    • Journal Title

      Cell

      Volume: 150 Issue: 2 Pages: 351-365

    • DOI

      10.1016/j.cell.2012.05.041

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pathological neoangiogenesis depends on oxidative stress regulation by ATM.2012

    • Author(s)
      Yuji Okuno
    • Journal Title

      Nature Medicine

      Volume: 18 Issue: 8 Pages: 1208-1216

    • DOI

      10.1038/nm.2846

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellul- ar matrix protein Tenascin-C is req- uired in the bone marrow microenvio- nment primed for hematopoietic rege- neration2012

    • Author(s)
      Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasa- wa T, Suda T, Kubota Y
    • Journal Title

      Blood

      Volume: 119 Issue: 23 Pages: 5429-5437

    • DOI

      10.1182/blood-2011-11-393645

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo behavior of multiple myeloma cells and their niche in immunodeficient mice2012

    • Author(s)
      Iriuchishima H, Kizaki M, et al
    • Journal Title

      PLoS ONE

      Volume: 7(2) Issue: 2 Pages: e30557-e30557

    • DOI

      10.1371/journal.pone.0030557

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Tracing the conversion process for primordial germ cells to pluripotent2012

    • Author(s)
      Nagamatsu G
    • Journal Title

      Biol Reprod

      Volume: 86 Issue: 6 Pages: 182-182

    • DOI

      10.1095/biolreprod.111.096792

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of N-cadherin in the regulation of HSPCs.2012

    • Author(s)
      Arai F
    • Journal Title

      Ann NY Acad Sci

      Volume: 1266 Pages: 72-77

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optimal ratio of transcription factors for somatic cell reprogramming.2012

    • Author(s)
      Nagamatsu G
    • Journal Title

      J Biol Chem

      Volume: 287 Issue: 43 Pages: 36273-36282

    • DOI

      10.1074/jbc.m112.380683

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-cadherin(+) HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin(-) HSCs.雑 誌 名2012

    • Author(s)
      Toyama H, Arai F, Hosokawa K, lkushima YM. Suda T
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 428(3) Issue: 3 Pages: 354-359

    • DOI

      10.1016/j.bbrc.2012.10.058

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner2011

    • Author(s)
      Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T, Kubota Y
    • Journal Title

      Dev Biol

      Volume: 363 Issue: 1 Pages: 106-114

    • DOI

      10.1016/j.ydbio.2011.12.027

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hemp, an mbt domain-containing protein, plays essential roles in hematopoietic stem cell function and skeletal formation2011

    • Author(s)
      Honda H(他10名 )
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 108 Issue: 6 Pages: 2468-2473

    • DOI

      10.1073/pnas.1003403108

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haematopoietic stem cell maintenance and mobilization2011

    • Author(s)
      Miyamoto K, et al
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 11 Pages: 2175-2181

    • DOI

      10.1084/jem.20101890

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p57^<Kip2> and p27^<Kip1> cooperate to maintain hematopoietic stem cell quiescence through interaction with Hsc702011

    • Author(s)
      Zou P, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Issue: 3 Pages: 247-261

    • DOI

      10.1016/j.stem.2011.07.003

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells serve as proangiogenic macrophages but not endothelial cells in wound healing2011

    • Author(s)
      Okuno Y(他4名)
    • Journal Title

      Blood

      Volume: 117 Issue: 19 Pages: 5264-5272

    • DOI

      10.1182/blood-2011-01-330720

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011

    • Author(s)
      Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 5 Pages: 949-960

    • DOI

      10.1084/jem.20102187

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism2011

    • Author(s)
      Nitta Eriko
    • Journal Title

      Blood

      Volume: 117 Issue: 16 Pages: 4169-80

    • DOI

      10.1182/blood-2010-08-297390

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression2011

    • Author(s)
      Iriuchishima H(他6名)
    • Journal Title

      Blood

      Volume: 117 Issue: 8 Pages: 2373-2377

    • DOI

      10.1182/blood-2010-07-294801

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells serve : as pro-angiogenic macrophages but not endothelial cells in wound healing2011

    • Author(s)
      Okuno Y, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 5264-5272

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic regulation of hematopoietic stem cells in the hypoxic niche2011

    • Author(s)
      Suda T, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Issue: 4 Pages: 298-310

    • DOI

      10.1016/j.stem.2011.09.010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Hematopoietic stem cells in the hypoxic niche2014

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia conference 2014 : Sensing and Signaling of Hypoxia: Interfaces with Biology and Medicine
    • Place of Presentation
      Breckenridge, Colorado, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Hematopoietic stem cells in the hypoxic niche.2014

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia
    • Place of Presentation
      Breckenridge, Colorado, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Hematopoiesis under the stress2013

    • Author(s)
      Suda T
    • Organizer
      Collaborative Meeting of the European and the Spanish Societies for Gene and Cell Therapy Palacio Municipal de Congresos
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Final Research Report
  • [Presentation] A metabolic guide to stem cell homeostasis2013

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia : Hematopoiesis
    • Place of Presentation
      Steamboat Springs, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Niche regulation for hematopoietic stem cells.2013

    • Author(s)
      Suda T
    • Organizer
      1st Shanghai International Workshop on Stem Cells in Cancer
    • Place of Presentation
      Shanghai, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Niche regulation for hematopoietic stem cells.2013

    • Author(s)
      Suda T
    • Organizer
      2013 Beijing International Workshop on Developmental Hematopoiesis
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Niche regulation for hematopoietic stem cells.2013

    • Author(s)
      Suda T
    • Organizer
      The Bone Marrow Niche, Stem Cells, and Leukemia: Impact of Drugs, Chemicals, and the Environment
    • Place of Presentation
      NY, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Hematopoietic stem cells in the hypoxic niches.2013

    • Author(s)
      Suda T
    • Organizer
      The Hemato-Vascular System: Development and Disease
    • Place of Presentation
      Baeza, Spain
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Hematopoiesis under the stress.2013

    • Author(s)
      Suda T
    • Organizer
      Collaborative Meeting of the European and the Spanish Societies for Gene and Cell Therapy Palacio Municipal de Congresos
    • Place of Presentation
      Madrid, Spain
    • Related Report
      2013 Annual Research Report
  • [Presentation] A metabolic guide to stem cell homeostasis.2013

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia: Hematopoiesis
    • Place of Presentation
      Steamboat Springs, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hematopoiesis under the stress.2013

    • Author(s)
      Suda T
    • Organizer
      USA-Japan Cooperative Cancer Workshop
    • Place of Presentation
      Maui, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hematopoietic stem cells in hypoxic niches2012

    • Author(s)
      Suda T
    • Organizer
      The 2012 Einstein Stem Cell Institute Symposium
    • Place of Presentation
      NY, USA
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Hematopoietic stem cell metabolism2012

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The life of a Stem Cell : From Birth to Death
    • Place of Presentation
      Olympic Valley, USA
    • Year and Date
      2012-03-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metabolic regulation of hematopoietic stem cells during stress2012

    • Author(s)
      Suda T
    • Organizer
      Metabolic regulation of hematopoietic stem cells during stress
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Glycolytic metabolism in hematopoietic stem cells.2012

    • Author(s)
      Suda T
    • Organizer
      ICCSR 10th Annual Meeting
    • Place of Presentation
      Yokohama, Japan
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] Hematopoietic stem cellmetabolism, Keystone Symposia on Molecular and Cellular Biology2012

    • Author(s)
      Suda T
    • Organizer
      The life of a Stem Cell : From Birth to Death
    • Place of Presentation
      Olympic Valley, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] The endosteal stem cell niche.2012

    • Author(s)
      Suda T
    • Organizer
      ESH-EHA Scientific Workshop: Anti-Inflammatory & Immune Modulatory Properties of MSCs
    • Place of Presentation
      Cannes, France
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Hematopoietic stem cells in the hypoxic niche.2012

    • Author(s)
      Suda T
    • Organizer
      The 17th International Vascular Biology Meeting
    • Place of Presentation
      Wiesbaden, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Regulation of hematopietic stem cells.2012

    • Author(s)
      Suda T
    • Organizer
      Nobel Conference ”Hematopoietic Stem Cells: From Basic to Regenerative Medicine”
    • Place of Presentation
      Stockholm, Sweden
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Normal and abnormal niches for hematopoietic stem cells.2012

    • Author(s)
      Suda T
    • Organizer
      The 8th Annual Meeting of Korean Society for Stem Cell research
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Metabolic regulation of HSCs during stress.2012

    • Author(s)
      Suda T
    • Organizer
      Stem Cells and Metabolism Conference
    • Place of Presentation
      La Jolla, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Metabolic regulation of hematopoietic stem cells during stress.2012

    • Author(s)
      Suda T
    • Organizer
      54th ASH Annual Meeting and Exposition
    • Place of Presentation
      Atlanta, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Niche for hematopoietic stem cells in bone marrow2011

    • Author(s)
      Suda T
    • Organizer
      The 2^<nd> Pacific Meeting for Angiogenesis and Lymphangiogenesis
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2011-10-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Glycolytic metabolism of hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      2011 Cold Spring Harbor Asia Conference : Cellular Programs and Reprogramming
    • Place of Presentation
      Suzhou, China
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      ISEH 40^<th> Annual Scientific Meeting
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      Heidelberg-Kyoto Joint Symposium "Crossing Boundaries : Stem Cells, Materials, and Mesoscopic Sciences"
    • Place of Presentation
      Heidelberg, Germany
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Hypoxic niche for hematopoietic stem cells and cancer stem cells2011

    • Author(s)
      Suda T
    • Organizer
      The 52nd Spring Meeting of the Korean Society of Hematology
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2011-05-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] Normal haematopoietic stem cells and the stem cell niche2011

    • Author(s)
      Suda T
    • Organizer
      The 11^<th> International Symposium on Myelodysplastic Syndromes
    • Place of Presentation
      Edinburgh, UK
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      ISEH 40th Annual Scientific Meeting
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Glycolytic metabolism of hematopoieic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      The 2nd ElseKroner-Fresenius Symposium on Molecular Mechanisms of Adult Srtem Cell Aging
    • Place of Presentation
      Gunzgurg, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Normal haematopoietic stem cells and the stem cell niche2011

    • Author(s)
      Suda T
    • Organizer
      The 11 th International Symposium on Myelodysplastic Syndromes
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.celldiff.med.keio.ac.jp/

    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 抗がん剤の効果増強剤2012

    • Inventor(s)
      齊藤秀, 小坂威雄, 永松剛, 堀本勝久, 大家基嗣, 須田年生
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-127405
    • Filing Date
      2012-06-04
    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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