| Co-Investigator(Kenkyū-buntansha) |
SETO Yasuyuki 東京大学, 医学部附属病院, 教授 (00260498)
NAKAJIMA Susumu 東京大学, 医学部附属病院, 准教授 (40323597)
MATSUBARA Takehiro 東京大学, 医学部附属病院, 特任講師 (40361498)
CHO Kyohiro 東京大学, 医学部附属病院, 講師 (50302708)
YAHAGI Naoki 東京大学, 医学部附属病院, 教授 (60158045)
UCHIDA Kanji 東京大学, 医学部附属病院, 准教授 (60302709)
YAGI Koichi 東京大学, 医学部附属病院, 助教 (90422310)
森 和彦 東京大学, 医学部附属病院, 講師 (10436470)
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| Budget Amount *help |
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2015: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2014: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
Sepsis and sepsis associated acute respiratory distress syndrome are diseases with high mortality without effective treatment options. Controversies to its pathogenesis and heterogeneity of the patient population are thought to be the failure of multiple clinical trials mainly aims to modulate hyperimmune state.
Retrospective analysis of parameters from patients admitted in the intensive care unit (ICU) in a single institute revealed that lower mean arterial pressure, white blood cell / platelet count, and higher serum lactate dehydrogenase on 1 day after ICU admission associated with in-hospital death. Mouse model of peritoneal sepsis induced by cecal ligation and puncture revealed that septic mice fell into immune compromised state 4-days after CLP and were susceptible to death following nosocomial infection. Systemic interferon beta improved survival of septic pneumonia model and may work to restore impaired innate immunity.
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