Innovative diagnosis and treatment seeds from the two-way analysis of xenograft model by the next generation mass spectrometry
| Project/Area Number |
23249073
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
OGAWA Osamu 京都大学, 医学(系)研究科(研究院), 教授 (90260611)
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| Co-Investigator(Kenkyū-buntansha) |
KANBA Tomomi 京都大学, 医学研究科, 准教授 (20402836)
INOUE Takahiro 京都大学, 医学研究科, 講師 (80511881)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥35,490,000 (Direct Cost: ¥27,300,000、Indirect Cost: ¥8,190,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Keywords | 前立腺癌 / 腎癌 / Xenograft / 質量分析 / バイオマーカー / 新規治療標的 / 患者癌組織由来xenograft / 腎細胞癌 / 治療抵抗性 / 網羅的遺伝子解析 / 次世代質量分析 / 革新的診断・治療シーズ / 患者癌組織由来Xenograft |
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| Outline of Final Research Achievements |
We have established patient-derived tumor tissue(PDTT) xenograft models of urological cancer. Using PDTT xenograft model, we have identified new molecules related with cancer progression and drug resistance by the next generation mass spectrometry. We are planning to evaluate whether these molecules could be biomarker or therapeutic target in clinical setting.
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Report
(4 results)
Research Products
(20 results)
