Development of a molecular-targeting therapeutic agent for cancer therapy using a cancer-targeting liposome coupled with viral proteins

• Project/Area Number: 23249084
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Chiba University
• Principal Investigator: TANZAWA HIDEKI 千葉大学, 医学(系)研究科(研究院), 教授 (50236775)
• Co-Investigator(Kenkyū-buntansha): SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194) ; SAITO Kengo 千葉大学, 大学院・医学研究院, 助教 (70451755)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000); Fiscal Year 2013: ¥12,350,000 (Direct Cost: ¥9,500,000、Indirect Cost: ¥2,850,000); Fiscal Year 2012: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000); Fiscal Year 2011: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
• Keywords: 臨床腫瘍学 / リポソーム / 腫瘍特異的 / 分子標的治療 / 分子標的薬

Research Abstract

We developed a new strategy of chemotherapy and/or radiation therapy against treatment-resistant tumor using with the cancer-targeting liposome loading the some sensitizer. In this therapy, these liposomes exhibited higher cytotoxicity to cancer cells than the only sensitizer and displayed the tumor regression in mice bearing a drug or radiation resistant tumor.

Research Products

• [Journal Article] Lipocalin-2 is associated with radioresistance in oral cancer and lung cancer cells (2013)
  • Author(s): Shiiba M, Saito K, Fushimi K, Ishigami T, Shinozuka K, Nakashima D, Kouzu Y, Koike H, Kasamatsu A, Sakamoto Y, Ogawara K, Uzawa K, Takiguchi Y, Tanzawa H
  • Journal Title: Int J Oncol Volume: 42(4) Pages: 1197-204
  • Peer Reviewed
• [Journal Article] Lipocalin-2 is associated with radioresistance in oral cancer and lung cancer cells. (2013)
  • Author(s): 椎葉正史、齋藤謙悟、鵜澤一弘
  • Journal Title: International journal of oncology Volume: 42 Issue: 4 Pages: 1197-1204
  • DOI: 10.3892/ijo.2013.1815
  • Peer Reviewed
• [Journal Article] Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe (2012)
  • Author(s): Suganami A, Toyota T, Okazaki S, Saito K, Miyamoto K, Akutsu Y, Kawahira H, Aoki A, Muraki Y, Madono T, Hayashi H, Matsubara H, Omatsu T, Shirasawa H, Tamura Y
  • Journal Title: Bioorg Med Chem Lett Volume: 22(24) Pages: 7481-5
  • Peer Reviewed
• [Journal Article] Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe. (2012)
  • Author(s): 菅波晃子、齋藤謙悟、白澤浩
  • Journal Title: Bioorganic & Medicinal Chemistry Letters Volume: 22 Issue: 24 Pages: 7481-7485
  • DOI: 10.1016/j.bmcl.2012.10.044
  • Peer Reviewed
• [Presentation] The effects of cancer-targeted liposomes loaded with PDE inhibitors on the cisplatin-resistance on cancer cells (2013)
  • Author(s): 齋藤謙悟
  • Organizer: 第72回癌学会
  • Place of Presentation: 横浜
• [Presentation] The effects of a cancer-targeted liposome loaded inhibitors to cisplatin resistance in the cancer cells (2012)
  • Author(s): 齋藤謙悟
  • Organizer: 第71回癌学会
  • Place of Presentation: 札幌
• [Presentation] The study of cancer-targeted liposome with viral proteins for imaging cancer cells (2011)
  • Author(s): 齋藤謙悟
  • Organizer: 第69回 日本癌学会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-03
• [Presentation] The study of cancer-targeted liposome with viral proteins for imaging cancer cells (2011)
  • Author(s): 齋藤謙悟
  • Organizer: 第70回癌学会
  • Place of Presentation: 名古屋
• [Presentation] The effects of cancer-targeted liposomes loaded with PDE inhibitors on the cisplatin-resistance on cancer cells
  • Author(s): 齋藤 謙悟
  • Organizer: 第72回 日本癌学会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] シスプラチン耐性阻害剤含有腫瘍標的リポソームの効果
  • Author(s): 齋藤 謙悟
  • Organizer: 第７１回 日本癌学会
  • Place of Presentation: ロイトン札幌（札幌）