Cortical regeneration and nestin-expressing reactive astrocyte in a novel closed-head injury model "photo-injury mouse"
Project/Area Number |
23300133
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Kobe University |
Principal Investigator |
MORITA Mitsuhiro 神戸大学, 理学(系)研究科(研究院), 准教授 (50297602)
|
Co-Investigator(Renkei-kenkyūsha) |
OKANO Hideyuki 慶應義塾大学, 医学部, 教授 (60160694)
MAEKAWA Shohei 神戸大学, 大学院理学研究科, 教授 (40173695)
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Project Period (FY) |
2011-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
|
Keywords | 脳傷害 / 組織再生 / 活性化アストロサイト / 閉鎖性脳傷害 / ネスチン / 脳組織再生 / 創傷治癒 / アストロサイト / 神経幹細胞 |
Outline of Final Research Achievements |
We have developed a novel brain injury model designated "photo-injury", which shows substantial cortical tissue regeneration. Further histological analysis showed a robust accumulation of nestin-expressing reactive astrocyte in the regenerating region. Since the genetic modification of the accumulation of the reactive astrocyte caused significant alteration of cortical regeneration, these cells were indicated to play a pivotal role in regeneration. Meanwhile, the majority of the reactive astrocyte was ablated during wound healing in our fate mapping study. These results suggest the nestin-expressing reactive astrocyte is one of the determinant of the process brain lesion and a potent diagnostic as well as therapeutic target of brain injury.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] Ganglioside contained in the NAP-22 fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.2015
Author(s)
Kobayashi, Y., Ronan da Silva, Kumanogoh, H., Miyata, S., Sato, C., Kitajima, K., Nakamura, S., Morita, M., Hayashi, F., Maekawa, S.
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Journal Title
J Neurosci Res
Volume: 未定
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Identification of dynamin as a septin-binding protein.2013
Author(s)
Maimaitiyiming, M., Kobayashi, Y., Kumanogoh, H., Nakamura, S., Morita, M., and Maekawa, S.
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Journal Title
Neurosci Lett
Volume: 534
Pages: 322-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Interaction of NAP-22 with brain glutamic acid decarboxylase (GAD)2013
Author(s)
Maekawa, M., Kobayashi, Y., Odagaki, S., Makino, M., Kumanogoh, H., Nakamura, S., Morita, M., Hayashi, F.
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Journal Title
Neurosci Lett
Volume: 537
Pages: 50-4
DOI
Related Report
Peer Reviewed
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