2014 Fiscal Year Final Research Report
Cortical regeneration and nestin-expressing reactive astrocyte in a novel closed-head injury model "photo-injury mouse"
Project/Area Number |
23300133
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Neurochemistry/Neuropharmacology
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Research Institution | Kobe University |
Principal Investigator |
MORITA Mitsuhiro 神戸大学, 理学(系)研究科(研究院), 准教授 (50297602)
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Co-Investigator(Renkei-kenkyūsha) |
OKANO Hideyuki 慶應義塾大学, 医学部, 教授 (60160694)
MAEKAWA Shohei 神戸大学, 大学院理学研究科, 教授 (40173695)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Keywords | 脳傷害 / 組織再生 / 活性化アストロサイト |
Outline of Final Research Achievements |
We have developed a novel brain injury model designated "photo-injury", which shows substantial cortical tissue regeneration. Further histological analysis showed a robust accumulation of nestin-expressing reactive astrocyte in the regenerating region. Since the genetic modification of the accumulation of the reactive astrocyte caused significant alteration of cortical regeneration, these cells were indicated to play a pivotal role in regeneration. Meanwhile, the majority of the reactive astrocyte was ablated during wound healing in our fate mapping study. These results suggest the nestin-expressing reactive astrocyte is one of the determinant of the process brain lesion and a potent diagnostic as well as therapeutic target of brain injury.
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Free Research Field |
神経科学
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