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Study on the molecular mechanisms underlying CAPS-mediated exocytosis of dense-core vesicles containing BDNF and catecholamine

Research Project

Project/Area Number 23300137
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTokyo University of Science

Principal Investigator

FURUICHI Teiichi  東京理科大学, 理工学部, 教授 (50219094)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
KeywordsCAPS1 / CAPS2 / 有芯小胞 / BDNF / トランスゴルジ網 / 自閉症 / CAPS2-dex3 / NT-3 / 社会行動 / Cadps2 / Arf4/5 / ゴルジ体 / 発達障害
Research Abstract

We showed that CAPS1 and CAPS2 interacts with Arf4/5, which is possibly involved in dense-core vesicle (DCV) trafficking in the trans-Golgi network (TGN). Dex3 (deletion of exon3) is a rare alternative splicing CAPS2 variant which was identified to be increased in some of patients with autism. We generated a dex3-expressing mice and verified an impairment in axonal dex3 localization, contributing to a reduction in BDNF release from axons and thereby resulting in abnormal synapses. Dex3 mice also showed deficits in social and anxiety behaviors, suggesting a possible association of dex3 with brain development and behavior related to autism. Although CAPS1 regulates insulin secretion, its function in the brain is essentially unknown because of neonatal death of CAPS1 KO mice. We generated CAPS1 conditional knockout mice and suggested that loss of CAPS1 disrupts the TGN-DCV pathway and BDNF release, which may be associated with a mechanism underlying diabetes and comorbid depression.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (67 results)

All 2013 2012 2011 Other

All Journal Article (28 results) (of which Peer Reviewed: 14 results) Presentation (32 results) (of which Invited: 4 results) Book (4 results) Remarks (3 results)

  • [Journal Article] CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain2013

    • Author(s)
      Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-SembaR, Sekine Y, Sato Y, Tanaka M, Iwasato T, Itohara S, Furuyama K, Kawaguchi Y, Ishizaki Y, Yuzaki M and Furuichi T
    • Journal Title

      J. Neurosci

      Volume: 33 Pages: 17326-17334

    • Related Report
      2013 Final Research Report
  • [Journal Article] Activation of cultured astrocytes by amphotericin B : Stimulation of NO and cytokines production and changes in neurotrophic factors2013

    • Author(s)
      Motoyoshi-Yamashiro A, Tamura M, Moriyama M, Takano K, Kawabe K, Nakajima H, Katoh-Semba R, Furuichi T and Nakamura Y
    • Journal Title

      Neurochem. Int

      Volume: 63 Pages: 93-100

    • Related Report
      2013 Final Research Report
  • [Journal Article] Astrocytic Ca^<2+> signals are required for the functional integrity of tripartite synapses2013

    • Author(s)
      Tanaka, M., Shih, PY., Gomi, H., Yoshida, H., Nakai, J., Ando, R., Furuichi, T., Mikoshiba, K., Semyanov, A., and Itohara, S
    • Journal Title

      Mol. Brain

      Volume: 6 Pages: 6-6

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene2013

    • Author(s)
      Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., and Furuichi, T
    • Journal Title

      FEBS Lett

      Volume: 587 Pages: 54-59

    • Related Report
      2013 Final Research Report
  • [Journal Article] Animal Models of Autism Spectrum Disorder (ASD) : A Synaptic-level Approach to Autistic-like Behavior in Mice2013

    • Author(s)
      Shinoda, Y., Sadakata, T., and Furuichi, T
    • Journal Title

      Exp. Anim

      Volume: 62(2) Pages: 71-78

    • NAID

      10031163545

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mouse models of mutations and variations in autism spectrum disorder-associated genes : mice expressing caps2/cadps2 copy number and alternative splicing variants2013

    • Author(s)
      Sadakata, T., Shinoda, Y., Sato, A., Iguchi, H., Ishii, C., Matsuo, M., Yamaga, R., Furuichi, T
    • Journal Title

      Int J Environ Res Public Health

      Volume: 10(12) Pages: 6335-6353

    • Related Report
      2013 Final Research Report
  • [Journal Article] CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain.2013

    • Author(s)
      Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Tanaka M, Iwasato T, Itohara S, Furuyama K, Kawaguchi Y, Ishizaki Y, Yuzaki M, Furuichi T.
    • Journal Title

      J Neurosci.

      Volume: 33 Issue: 44 Pages: 17326-17334

    • DOI

      10.1523/jneurosci.2777-13.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autistic-like behavioral phenotypes in a mouse model with copy number variation of the CAPS2/CADPS2 gene2013

    • Author(s)
      Sadakata T, Shinoda Y, Oka M, Sekine Y, Furuichi T.
    • Journal Title

      FEBS Lett

      Volume: 587 Issue: 1 Pages: 54-59

    • DOI

      10.1016/j.febslet.2012.10.047

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mouse models of mutations and variations in autism spectrum disorder-associated genes : mice expressing caps2/cadps2 copy number and alternative splicing variants2013

    • Author(s)
      Sadakata T, Shinoda Y, Sato A, Iguchi H, Ishii C, Matsuo M, Yamaga R, Furuichi T
    • Journal Title

      Int J Environ Res Public Health

      Volume: 10 Issue: 12 Pages: 6335-6353

    • DOI

      10.3390/ijerph10126335

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Animal Models of Autism Spectrum Disorder (ASD): A Synaptic-Level Approach to Autistic-Like Behavior in Mice2013

    • Author(s)
      Shinoda Y, Sadakata T, Furuichi T
    • Journal Title

      Experimental Animals

      Volume: 62 Issue: 2 Pages: 71-78

    • DOI

      10.1538/expanim.62.71

    • NAID

      10031163545

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice2012

    • Author(s)
      Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., Sato, Y., Saruta, C., Miwa, H., Tanaka, M., Itohara, S., and Furuichi, T
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A

      Volume: 109 Pages: 21104-21109

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clustered fine compartmentalization of the mouse embryonic cerebellar cortex is rearranged into the postnatal striped organization2012

    • Author(s)
      Fujita, H., Morita, N., Unno, T., Furuichi, T., and Sugihara, I
    • Journal Title

      J. Neurosci

      Volume: 32 Pages: 15688-15703

    • Related Report
      2013 Final Research Report
  • [Journal Article] Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking2012

    • Author(s)
      Sadakata, T., Sekine, Y., Oka, M., Itakura, M., and Furuichi, T
    • Journal Title

      FEBS J.

      Volume: 279 Pages: 384-394

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reduced axonal localization of a Caps2 splice variant impairs axonal release of BDNF and causes autistic-like behavior in mice.2012

    • Author(s)
      Sadakata, T., Shinoda, Y., Oka, M., Sekine, Y., Sato, Y., Saruta, C., Miwa, H., Tanaka, M., Itohara, S., and Furuichi, T.
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A.

      Volume: 109 Issue: 51 Pages: 21104-21109

    • DOI

      10.1073/pnas.1210055109

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clustered fine compartmentalization of the mouse' embryonic cerebellar cortex and its rearrangement into the postnatal striped configuration.2012

    • Author(s)
      Fujita H, Morita N, Furuichi T, Sugihara I
    • Journal Title

      J Neurosci.

      Volume: 32 Issue: 45 Pages: 15688-15703

    • DOI

      10.1523/jneurosci.1710-12.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BDNFの分泌制御と脳神経回路の形成~CAPS2によるBDNF分泌促進とその機能的役割~2012

    • Author(s)
      篠田陽
    • Journal Title

      生化学

      Volume: 84 Pages: 106-111

    • NAID

      10030346386

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.2012

    • Author(s)
      Sadakata T
    • Journal Title

      FEBS JOURNAL

      Volume: 279 Issue: 3 Pages: 384-394

    • DOI

      10.1111/j.1742-4658.2011.08431.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自閉症の発症要因と動物モデル2012

    • Author(s)
      篠田陽
    • Journal Title

      実験医学増刊号

      Volume: 30 Pages: 236-241

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLD4 is involved in phagocytosis of microglia : expression and localization changes of PLD4 are correlated with activation state of micrglia2011

    • Author(s)
      Otani, Y., Yamaguchi, Y., Sato, Y., Furuichi, T., Ikenaka, K., Kitani, H., and Baba, H
    • Journal Title

      PLoS One

      Volume: 6(11)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 protein levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats2011

    • Author(s)
      Hamatake, M., Miyazaki, N., Sudo, K., Matsuda, M., Sadakata, T., Furuya, A., Ichisaka, S., Hata, Y., Nakagawa, C., Nagata, K., Furuichi, T., Katoh-Semba, R
    • Journal Title

      J. Biol. Chem

      Volume: 286 Pages: 21478-21487

    • Related Report
      2013 Final Research Report
  • [Journal Article] Interaction between very-KIND RasGEF and MAP2, and its role in dendrite growth : structure and function of the second kinase non-catalytic C-lobe domain2011

    • Author(s)
      Huang, J., Furuya, A., Hayashi, K., and Furuichi, T
    • Journal Title

      FEBS J

      Volume: 278 Pages: 1651-1661

    • Related Report
      2013 Final Research Report
  • [Journal Article] Calcium-dependent activator protein for secretion 2 (CAPS2) promotes BDNF secretion and is critical for the development of GABAergic interneuron network2011

    • Author(s)
      Shinoda, Y., Sadakata, T., Nakao, K., Katoh-Semba, R., Kinameri, E., Furuya, A., Yanagawa, Y., Hirase, H., and Furuichi, T
    • Journal Title

      Proc. Natl. Acad. Sci. U.S.A

      Volume: 108 Pages: 373-378

    • NAID

      120002771000

    • Related Report
      2013 Final Research Report
  • [Journal Article] Systematizing and cloning of genes involved in the cerebellar cortex circuit development2011

    • Author(s)
      Furuichi, T., Shiraishi-Yamaguchi, Y., Sato, A., Sadakata, T., Huang, J., Shinoda, Y., Hayashi, K., Mishima, Y., Tomomura, M., Nishibe, H., and Yoshikawa, F
    • Journal Title

      Neurochem Res

      Volume: 36 Pages: 1241-1252

    • Related Report
      2013 Final Research Report
  • [Journal Article] Interaction between very-KIND RasGEF and MAP2, and its role in dendrite growth: structure and function of the second kinase non-catalytic C-lobe domain.2011

    • Author(s)
      Huang J
    • Journal Title

      FEBS JOURNAL

      Volume: 278 Issue: 10 Pages: 1651-1661

    • DOI

      10.1111/j.1742-4658.2011.08085.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase advance of the light-dark cycle perturbs diurnal rhythms of brain-derived neurotrophic factor and neurotrophin-3 levels, which reduces synaptophysin-positive presynaptic terminals in the cortex of juvenile rats.2011

    • Author(s)
      Hamatake M, Miyazaki N, Sudo K, Matsuda M, Sadakata T, Furuya A, Ichisaka S, Hata Y, Nakagawa C, Nagata K, Furuichi T, Katoh-Semba R
    • Journal Title

      J. Biol. Chem.

      Volume: 286 Issue: 24 Pages: 21478-21487

    • DOI

      10.1074/jbc.m110.195859

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Systematizing and cloning of genes involved in the cerebellar cortex circuit development2011

    • Author(s)
      Teiichi Furuichi, Yoko Shiraishi-Yamaguchi, Akira Sato, Tetsushi Sadakata, Jinhong Huang, Yo Shinoda, Kanehiro Hayashi, Yuriko Mishima, Mineko Tomomura, Hirozumi Nishibe, Fumio Yoshikawa
    • Journal Title

      Neurochem Res.

      Volume: 36(7) Issue: 7 Pages: 1241-52

    • DOI

      10.1007/s11064-011-0398-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLD4 Is Involved in Phagocytosis of Microglia: Expression and Localization Changes of PLD4 Are Correlated with Activation State of Microglia2011

    • Author(s)
      Otani O
    • Journal Title

      PLOS ONE

      Volume: 6 Issue: 11 Pages: 27544-27544

    • DOI

      10.1371/journal.pone.0027544

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自閉症感受性候補遺伝子CAPS2/CADPS2における遺伝的多型とノックアウトマウスの行動障害2011

    • Author(s)
      定方哲史
    • Journal Title

      医学のあゆみ/精神発達遅延・自閉症の分子医学

      Volume: 239 Pages: 701-707

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脳の正常な発達とその障害-分泌関連因子CAPS ファミリーの機能2013

    • Author(s)
      古市貞一
    • Organizer
      都医学研セミナー
    • Year and Date
      2013-01-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Ca^<2+>依存性分泌関連タンパク質CAPS ファミリーのマウス胚脳神経系における遺伝子発現2013

    • Author(s)
      三島百合子, 須田翔子, 猿田千尋, 定方哲史, 篠田陽, 和田直之, 小島正巳, 若菜茂晴, 古市貞一
    • Organizer
      第86回日本生化学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] CAPS1 コンディショナル・ノックアウトマウスにおけるシナプス伝達2013

    • Author(s)
      石井千晶, 篠田陽, 定方哲史, 古市貞一
    • Organizer
      Neuro2013
    • Related Report
      2013 Final Research Report
  • [Presentation] マウスドーパミン作動性神経の初代培養系における大型有芯小胞からのドーパミン分泌とCAPS2 の関係2013

    • Author(s)
      井口大壽, 小林翔太, 定方哲史, 篠田陽, 古市貞一
    • Organizer
      Neuro2013
    • Related Report
      2013 Final Research Report
  • [Presentation] Ca2+依存性分泌関連タンパク質CAPSファミリーのマウス胚脳神経系における遺伝子発現2013

    • Author(s)
      三島百合子、須田翔子、猿田千尋、定方哲史、篠田陽、和田直之、小島正巳、若菜茂晴、古市貞一
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ナプトタグミン3:ポストシナプスタンパク質の表面発現制御因子2013

    • Author(s)
      篠田陽、阿部麗実、古市貞一
    • Organizer
      Neuro2013
    • Place of Presentation
      京都・国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] CAPS1コンディショナル・ノックアウトマウスにおけるシナプス伝達2013

    • Author(s)
      石井千晶、篠田陽、定方哲史、古市貞一
    • Organizer
      Neuro2013
    • Place of Presentation
      京都・国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウスドーパミン作動性神経の初代培養系における大型有芯小胞からのドーパミン分泌とCAPS2の関係2013

    • Author(s)
      井口大壽、小林翔太、定方哲史、篠田陽、古市貞一
    • Organizer
      Neuro2013
    • Place of Presentation
      京都・国立京都国際会館
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳の正常な発達とその障害-分泌関連因子CAPSファミリーの機能2013

    • Author(s)
      古市貞一
    • Organizer
      都医学研セミナー
    • Place of Presentation
      東京都医学総合研究所
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 胎児期低栄養曝露された申請仔の遺伝子発現2013

    • Author(s)
      若菜茂晴、古瀬民生、幸田尚、古市貞一、三宅邦夫、久保田建夫
    • Organizer
      第83回日本衛生学会学術総会
    • Place of Presentation
      金沢大学鶴間・宝町キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス初代培養ドーパミンニューロンにおけるCAPSタンパク質の発現と大型有芯小胞開口放出との関係2013

    • Author(s)
      井口大壽、小林翔太、定方哲史、篠田陽、古市貞一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] CADPSタンパク質は視床下部オキシトシン産生ニューロンで発現し、下垂体後葉と共局在する2013

    • Author(s)
      山鹿亮祐、長江彩那、定方哲史、篠田陽、古市貞一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] CAPS2によるBDNFの放出の制御2013

    • Author(s)
      松尾誠、中川直紀、篠田陽、古市貞一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] BDNFによって増強される興奮性シナプス小胞分泌のメカニズム2013

    • Author(s)
      土井樹、古市貞一、篠田陽、Camin Dean
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 刺激の違いによるBDNF放出動態の比較とCAPS2活性に関わるCa2+チャネルの特定2013

    • Author(s)
      中川直紀、篠田陽、古市貞一、松尾誠
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synaptotagmin3:小胞分泌-取り込み制御分子としての役割2013

    • Author(s)
      阿部麗実、篠田陽、古市貞一、Camin Dean
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] CAPS1 cKO マウスの海馬におけるシナプス伝達2013

    • Author(s)
      石井千晶、篠田陽、定方哲史、古市貞一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] PC12におけるVMAT2-pHluorin利用した大型有芯小胞の開口放出イメージング2013

    • Author(s)
      小林翔太、佐藤友美、篠田陽、定方哲史、井口大壽、古市貞一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳特異的BAD-LAMPの発現と機能2013

    • Author(s)
      齊藤由弦、藤原真奈、篠田陽、古市貞一
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳の正常な発達とその障害-分泌関連因子CAPS2 の役割について2012

    • Author(s)
      古市貞一
    • Organizer
      埼玉大学・研究機構 脳科学融合研究センター シンポジウム(III) 脳の発生・発達とその破綻の理解をめざして
    • Year and Date
      2012-10-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Co-localization of Ca^<2+>-dependent activator protein for secretion (CAPS) proteins with oxytocin in the mouse pituitary2012

    • Author(s)
      Ayana Nagae, Yumi Sato, Tetsushi Sadakata, Yo Shinoda, and Teiichi Furuichi
    • Organizer
      第35回日本神経科学大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 有芯小胞分泌調節分子CAPS2 遺伝子欠損マウスにおける行動障害2012

    • Author(s)
      古市貞一
    • Organizer
      日本実験動物科学・技術
    • Place of Presentation
      九州
    • Related Report
      2013 Final Research Report
  • [Presentation] 有芯小胞分泌調節分子CAPS2遺伝子欠損マウスにおける行動障害2012

    • Author(s)
      古市貞一
    • Organizer
      日本実験動物科学・技術 九州 2012
    • Place of Presentation
      別府、大分県
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 脳の正常な発達とその障害-分泌関連因子CAPS2の役割について2012

    • Author(s)
      古市貞一
    • Organizer
      埼玉大学・研究機構 脳科学融合研究センター シンポジウム(III) 脳の発生・発達とその破綻の理解をめざして
    • Place of Presentation
      埼玉大学、埼玉県
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Co-localization of Ca2+-dependent activator protein for secretion (CAPS)proteins with oxytocin in the mouse pituitary2012

    • Author(s)
      Ayana Nagae, Yumi Sato, Tetsushi Sadakata, Yo Shinoda, and Teiichi Furuichi
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋市国際会議場
    • Related Report
      2012 Annual Research Report
  • [Presentation] Examining the effects of chronic corticosterone administration in Ca^<2+>-dependent activator protein for secretion 2 (Caps2) knockout mice : implication for anxiety/depression-like behaviors2011

    • Author(s)
      Mishima Y, Sadakata T, Semba-Katoh R, Saruta C and Furuichi T
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Related Report
      2013 Final Research Report
  • [Presentation] Enhanced secretion of BDNF by CAPS2 is critical for proper brain development and behavior2011

    • Author(s)
      Furuichi T, Sadakata T and Shinoda Y
    • Organizer
      The 32nd Naito Conference
    • Related Report
      2013 Final Research Report
  • [Presentation] 長期的なコルチコステロン投与による不安・欝様行動への影響 : Ca^<2+>-dependent activator protein for secretion 2(Caps2)遺伝子欠損マウスを用いた実験.2011

    • Author(s)
      三島百合子, 定方哲史, 仙波りつ子, 猿田千尋, 古市貞一
    • Organizer
      第34回日本神経科学大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 長期的なコルチコステロン投与による不安・欝様行動への影響:Ca2+-dependent activator protein for secretion 2(Caps2)遺伝子欠損マウスを用いた実験.2011

    • Author(s)
      三島百合子
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミクログリアの活性化に伴うPLD4発現調節機構2011

    • Author(s)
      大谷嘉典
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      石川
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enhanced secretion of BDNF by CAPS2 is critical for proper brain development and behavior.2011

    • Author(s)
      Furuichi T
    • Organizer
      The 32nd Naito Conference
    • Place of Presentation
      yamanashi, Japan
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Examining the effects of chronic corticosterone administration in Ca2+-dependent activator protein for secretion 2 (Caps2) knockout mice: implication for anxiety/depression-like behaviors.2011

    • Author(s)
      Mishima Y
    • Organizer
      Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Annual Research Report
  • [Book] ゴルジ体における有芯小胞の生合成とCAPSタンパク質の役割,生体の科学2012

    • Author(s)
      定方哲史, 篠田 陽, 古市貞一
    • Related Report
      2013 Final Research Report
  • [Book] 自閉症の発症要因と動物モデル 実験医学2012

    • Author(s)
      篠田 陽, 定方哲史, 三島百合子, 古市貞一
    • Related Report
      2013 Final Research Report
  • [Book] BDNF の分泌制御と脳神経回路の形成~CAPS2 によるBDNF 分泌促進とその機能的役割~生化学2012

    • Author(s)
      篠田 陽, 古市貞一
    • Related Report
      2013 Final Research Report
  • [Book] 自閉症感受性候補遺伝子CAPS2/CADPS2 における遺伝的多型とノックアウトマウスの行動障害 医学のあゆみ2011

    • Author(s)
      定方哲史, 古市貞一
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://www.lmn.bs.noda.tus.ac.jp/#!homej/c1lby

    • Related Report
      2013 Final Research Report
  • [Remarks] CAPS1 cKOマウスの表現型の解析 糖尿病 とうつ病が併発するメカニズム との関連性を示唆

    • URL

      http://www.lmn.bs.noda.tus.ac.jp/#!homej/c1lby

    • Related Report
      2013 Annual Research Report
  • [Remarks] CAPS2 dex3マウスの表現型の解析 自閉症モデルマウスの作製に成功

    • URL

      http://www.lmn.bs.noda.tus.ac.jp/#!homej/c1lby

    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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